7 completed, 1 recruiting, 1 withdrawn. 5 Phase 4, 2 Not applicable, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 5 | Completed 5 |
| Not applicable | 2 | Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow Methylergonovine: new trials by email Literature Review of Methylergonovine trials Research Report on Methylergonovine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ergometrine Versus Carbetocin to Decrease Blood Loss in Myomectomy Methylergometrine (Intramyometrial Injection), Carbetocin (Intramyometrial Injection) - Myoma;Uterus | Not applicable | Recruiting | Cairo University | 40 | 2026-01-18 | 2026-02-05 |
| Prophylactic Methylergonovine for Twin Cesarean Methylergonovine, Placebo - Twin; Complicating Pregnancy, Postpartum Hemorrhage | Phase 4 | Completed | Columbia University | 66 | 2023-03-07 | 2025-06-13 |
| Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections Methylergonovine - Uterine Atony, Uterine Tone Disorders | Early Phase 1 | Withdrawn | Johns Hopkins University | 2020-07-01 | 2020-08-03 | |
| Multimodal Uterotonics at the Time of Cesarean Section in Laboring Patients Methylergonovine, Normal Saline (placebo) - Uterine Atony With Hemorrhage | Phase 4 | Completed | Cynthia Wong | 160 | 2019-06-08 | 2022-08-01 |
| Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial 15-methyl prostaglandin F2α, Methylergonovine Maleate - Postpartum Hemorrhage, Uterine Atony | Phase 4 | Completed | Brigham and Women's Hospital | 100 | 2019-03-01 | 2025-10-16 |
| Misoprostol Versus Active Management of Labour in CS Misoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine, Syntocinon and using extra uterotonic drugs when needed ; methergine carboprost - Cesarean Section | Phase 1 | Completed | Aljazeera Hospital | 300 | 2017-12-28 | 2022-11-16 |
| Uterotonic Prophylaxis Trial Methergine, placebo - Hemorrhage | Phase 4 | Completed | University of California, San Francisco | 284 | 2015-03-01 | 2019-09-06 |
| Oxytocin And Uterotonic Agent Use For Cesarean Delivery Oxytocin Infusion, Oxytocin Bolus - Uterine Atony, Hypotension | Phase 4 | Completed | Brigham and Women's Hospital | 60 | 2011-04-01 | 2017-06-29 |
| Reduction of Endometritis After Cesarean Section With the Routine Use of Methergine Methergine - Endometritis | Not applicable | Completed | University of South Florida | 44 | 2008-12-01 | 2012-09-19 |
Uterine Inertia (4) · Hemorrhage (3) · Postpartum Hemorrhage (3) · Endometritis (1) · Hypotension (1) · Myofibroma (1) · Pregnancy Complications (1)
Brigham and Women's Hospital (2) · Aljazeera Hospital (1) · Cairo University (1) · Columbia University (1) · Cynthia Wong (1) · Johns Hopkins University (1) · University of California, San Francisco (1) · University of South Florida (1)
United States (7) · Egypt (2)
Jennifer Kerns, MD (1) · Karen Lindeman, MD (1) · Lawrence C Tsen, MD (1) · Mahmoud Alalfy, M.s.c (1) · Mirella Mourad (1) · Naida M Cole, MD (1) · Nicole M Masse, MD (1) · Patrick Teefey, MD (1)
PMID 23942040, PMID 26855249, PMID 30821683, PMID 31893076, PMID 32532486, PMID 33232518, PMID 33461754, PMID 34741454, PMID 35852267, PMID 36303616, PMID 36989026, PMID 38453041, PMID 39326051