18 completed, 3 unknown, 1 recruiting, 1 withdrawn. 10 Not applicable, 6 Phase 3, 5 Phase 4, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 8, Recruiting 1, Unknown 1 |
| Phase 3 | 6 | Completed 5, Withdrawn 1 |
| Phase 4 | 5 | Completed 3, Unknown 2 |
| Phase 1 | 2 | Completed 2 |
Follow Methacholine Chloride: new trials by email Literature Review of Methacholine Chloride trials Research Report on Methacholine Chloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Sensitivity and Specificity of Inhaled Methacholine in Bronchial Provocation Test Methacholine Chloride - Asthma | Not applicable | Unknown | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 280 | 2022-12-01 | 2022-12-02 |
| Pharmacodynamic Equivalence of the Test and Reference Metered Dose Inhalers (MDIs) Containing Albuterol Sulfate in Adult Patients With Stable Mild Asthma Albuterol Sulfate inhalation aerosol 108 mcg per actuation, Proair HFA (Albuterol Sulfate) or FDA authorized generic: Albuterol Sulfate HFA (Teva Pharmaceutical USA, Inc.) Inhalation Aerosol 108 mcg per actuation, Proair HFA or FDA authorized generic: Albuterol Sulfate HFA Inhalation Placebo - Mild Asthma | Not applicable | Recruiting | Intech Biopharm Ltd. | 148 | 2022-08-15 | 2025-02-17 |
| Pharmacodynamic Bioequivalence Study of Albuterol Sulfate Inhalation Aerosol, 0.09 mg Albuterol Base/ Inhalation Methacholine Chloride, Albuterol Sulfate HFA 0.09 mg (Reference), Albuterol Sulfate HFA 0.18 mg (Reference) - Bronchial Asthma | Phase 3 | Withdrawn | Aurobindo Pharma Ltd | 2022-04-01 | 2022-05-20 | |
| Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol Methacholine (MCh) Challenge Testing, Eucapneic Voluntary Hyperventilation (EVH), Mannitol Inhalation Kit - Asthma, Cough | Phase 4 | Completed | Dr. Diane Lougheed | 45 | 2022-03-01 | 2026-08-12 |
| The Effect of Deep Inhalation on Mannitol Responsiveness Deep inhalation technique, Tidal breathing technique, Methacholine - Asthma | Phase 3 | Completed | University of Saskatchewan | 26 | 2018-06-01 | 2019-05-15 |
| Pharmacodynamic Bioequivalence of Metered Dose Inhalers of Albuterol Sulfate in Patients With Stable Mild Asthma methacholine chloride, placebo ProAir HFA, ProAir HFA - Mild Persistent Asthma | Phase 3 | Completed | Lupin, Inc. | 217 | 2016-04-01 | 2020-12-04 |
| Asthma Exacerbations and Vascular Function Mannitol, Methacholine, Placebo - Asthma | Not applicable | Completed | University of Alberta | 52 | 2015-12-01 | 2021-07-01 |
| Comparison of Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers methacholine, Wright Nebulizer, Devilbiss646 Nebulizer - Asthma | Not applicable | Completed | Guangzhou Institute of Respiratory Disease | 22 | 2015-07-01 | 2018-02-19 |
| Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics methacholine, adenosine monophosphate, leukotriene D4 - Asthma | Phase 4 | Unknown | Zhujiang Hospital | 80 | 2015-04-01 | 2015-10-16 |
| A Study to Evaluate Efficacy and Safety of Methacholine Chloride Challenge Test in Diagnosis of Adult Asthma Methacholine Chloride (SK-1211) - Asthma | Phase 3 | Completed | Sanwa Kagaku Kenkyusho Co., Ltd. | 2014-04-01 | 2014-11-17 | |
| Study of Methacholine Chloride Inhalation Challenge in Children With Bronchial Asthma Methacholine Chloride (SK-1211) - Asthma | Phase 3 | Completed | Santen Pharmaceutical Co., Ltd. | 10 | 2014-02-01 | 2017-03-29 |
| Dose-Response of Salmeterol in Children Advair Diskus100/50 µg, Flovent Diskus 100 µg, Methacholine Chloride - Asthma | Phase 4 | Completed | University of Florida | 10 | 2013-08-01 | 2014-10-07 |
| Change in Airway Responsiveness After Allergen Exposure Mannitol, Methacholine Chloride - Allergic Asthma | Not applicable | Completed | University of Saskatchewan | 11 | 2012-10-01 | 2015-04-09 |
| Mannitol (Aridol) and Methacholine (Provocholine) Responsiveness Methacholine (Provocholine), Mannitol (Aridol) - Asthma | Phase 4 | Completed | University of Saskatchewan | 20 | 2011-11-01 | 2016-10-27 |
| A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population methacholine and mannitol bronchial challenge tests - Asthma | Not applicable | Completed | BL&H Co., Ltd | 104 | 2011-07-01 | 2014-04-04 |
| Comparison of the Methacholine PC20 Between the Trudell Aeroeclipse* II Ban Nebulizer and the Wright Nebulizer Methacholine Chloride, Trudell AeroEclipse*II BAN nebulizer, The English-Wright nebulizer - Asthma | Not applicable | Completed | McMaster University | 46 | 2011-04-01 | 2015-04-15 |
| Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests high-dose methacholine challenge test, mannitol challenge test - Asthma, Cough Variant Asthma | Not applicable | Completed | Dr. Diane Lougheed | 29 | 2010-02-01 | 2022-02-28 |
| A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for Asthmatics and Non-asthmatics Technosphere Insulin Inhalation Powder, Salbutamol (Albuterol), Methacholine chloride - Asthma, Diabetes Mellitus | Phase 1 | Completed | Mannkind Corporation | 30 | 2008-05-01 | 2012-06-13 |
| Effects of Multiple Nasal Exposures to House Dust Mite Allergen on Nasal and Body Inflammation and Airway Sensitivity Dust mite extract, Fluticasone, Methacholine - Allergic Rhinitis | Not applicable | Completed | Novartis | 18 | 2007-07-01 | 2008-07-15 |
| Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma exhaled nitric oxide measurement, bronchial hyperresponsiveness with methacholine (PC20M), symptom score diary (according to 2007 GINA guidelines) - Asthma | Phase 4 | Unknown | Medical University of Lodz | 120 | 2007-02-01 | 2013-02-07 |
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Asthma (19) · Hypersensitivity (3) · Cough (2) · Cough-Variant Asthma (2) · Bronchial Hyperreactivity (1) · Diabetes Mellitus (1) · Inflammation (1) · Rhinitis, Allergic (1)
University of Saskatchewan (3) · Dr. Diane Lougheed (2) · University of Florida (2) · Aurobindo Pharma Ltd (1) · BL&H Co., Ltd (1) · Boehringer Ingelheim (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Guangzhou Institute of Respiratory Disease (1) · Intech Biopharm Ltd. (1) · Lupin, Inc. (1) · Mannkind Corporation (1) · McMaster University (1) · Medical University of Lodz (1) · Novartis (1) · Santen Pharmaceutical Co., Ltd. (1)
Canada (7) · United States (5) · China (3) · Japan (2) · Australia (1) · India (1) · Poland (1) · Taiwan (1) · United Kingdom (1)
Anders H. Boss (1) · David Pearlman, MD (1) · Diane Lougheed, MD (1) · Donald W Cockcroft, MD (1) · Dr. Don Cockcroft, MD (1) · Gail Gauvreau, PhD (1) · Huizhen Fan, Doctor (1) · Iwona Stelmach, MD, PhD, Prof (1) · Jinping Zheng (1) · Joseph Marialouis, MD (1) · Leslie Hendeles, PharmD (1) · M. Diane Lougheed, MD, MSc (1) · Michael K Stickland, PhD (1)
PMID 23987192, PMID 24702886, PMID 24975800, PMID 25871542, PMID 31542451, PMID 31785175, PMID 37459335