39 completed. 39 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 39 | Completed 39 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 1 | Completed 1 |
Follow merphos: new trials by email Literature Review of merphos trials Research Report on merphos
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer Cisplatin, Doxorubicin, Methotrexate - Stage II Bladder Cancer AJCC v8, Stage IIIA Bladder Cancer AJCC v8 | Phase 2 | Completed | University of Washington | 17 | 2020-11-24 | 2025-09-18 |
| Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer Methotrexate, Pharmacokinetic Study, Regorafenib - KRAS Gene Mutation, Metastatic Malignant Neoplasm in the Brain | Phase 2 | Completed | Stanford University | 22 | 2018-08-14 | 2023-08-01 |
| Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement Azacitidine, Biospecimen Collection, Computed Tomography - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 78 | 2017-04-01 | 2025-02-27 |
| Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer Methotrexate, Vinblastine, Doxorubicin - High Grade Upper Tract Urothelial Carcinoma | Phase 2 | Completed | ECOG-ACRIN Cancer Research Group | 36 | 2015-08-27 | 2023-07-10 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 84 | 2015-03-23 | 2026-06-01 |
| JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis Allogeneic Hematopoietic Stem Cell Transplantation, Busulfan, Cyclophosphamide - Primary Myelofibrosis, Secondary Myelofibrosis | Phase 2 | Completed | Fred Hutchinson Cancer Center | 61 | 2014-10-20 | 2026-03-30 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 20 | 2014-04-10 | 2024-03-12 |
| Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma Carboplatin, Cognitive Assessment, Cyclophosphamide - Desmoplastic/Nodular Medulloblastoma, Medulloblastoma | Phase 2 | Completed | Children's Oncology Group | 26 | 2013-12-24 | 2023-01-09 |
| Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Brentuximab Vedotin, Crizotinib, Cyclophosphamide - Anaplastic Large Cell Lymphoma, ALK-Positive, Ann Arbor Stage II Noncutaneous Childhood Anaplastic Large Cell Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 137 | 2013-11-13 | 2024-04-30 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| CMC-544 and Allogeneic Transplantation for CD22 Positive-Lymphoid Malignancies Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Anti-Thymocyte Globulin - Hematopoietic and Lymphoid Cell Neoplasm | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 27 | 2012-10-29 | 2024-07-23 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| Ofatumumab in Combination With Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulfate, and Dexamethasone Alternating With Ofatumumab in Combination With Cytarabine and Methotrexate in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma Autologous Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Cytarabine - Stage I Mantle Cell Lymphoma, Stage II Contiguous Mantle Cell Lymphoma | Phase 2 | Completed | Roswell Park Cancer Institute | 37 | 2011-12-06 | 2024-02-07 |
| Combination Chemotherapy and Ofatumumab in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Cyclophosphamide, Cytarabine, Dexamethasone - Acute Lymphoblastic Leukemia, Adult Acute Lymphoblastic Leukemia in Complete Remission | Phase 2 | Completed | M.D. Anderson Cancer Center | 72 | 2011-07-12 | 2021-05-03 |
| Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer methotrexate, liposomal cytarabine, quality-of-life assessment - Central Nervous System Metastases, Leptomeningeal Metastases | Phase 2 | Completed | University of Washington | 3 | 2011-04-01 | 2017-07-07 |
| Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Alemtuzumab, Allogeneic Hematopoietic Stem Cell Transplantation, Autologous Hematopoietic Stem Cell Transplantation - Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | Phase 2 | Completed | National Cancer Institute (NCI) | 66 | 2010-12-14 | 2023-04-04 |
| Busulfan, Fludarabine Phosphate, and Anti-Thymocyte Globulin Followed By Donor Stem Cell Transplant and Azacitidine in Treating Patients With High-Risk Myelodysplastic Syndrome and Older Patients With Acute Myeloid Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Anti-Thymocyte Globulin, Azacitidine - Acute Myeloid Leukemia, Adult Acute Megakaryoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 68 | 2010-07-15 | 2022-08-04 |
| Dose Dense MVAC for Muscle Invasive Bladder Cancer single arm dose dense MVAC - Muscle Invasive Bladder Cancer, High Risk Urothelial Carcinoma of the Upper Urinary Tracts | Phase 2 | Completed | Fox Chase Cancer Center | 54 | 2009-12-07 | 2019-09-17 |
| Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders Allogeneic Bone Marrow Transplantation, Anti-Thymocyte Globulin, Cyclosporine - Non-Neoplastic Hematologic and Lymphocytic Disorder | Phase 2 | Completed | Fred Hutchinson Cancer Center | 98 | 2009-07-31 | 2021-08-13 |
| Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma L-asparaginase, doxorubicin hydrochloride, therapeutic hydrocortisone - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 148 | 2009-03-01 | 2017-01-27 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (15) · Leukemia, Myeloid, Acute (9) · Burkitt Lymphoma (8) · Leukemia, Myeloid, Accelerated Phase (8) · Congenital Abnormalities (7) · Blast Crisis (6) · Lymphoma, Mantle-Cell (6) · Leukemia, Myeloid, Chronic-Phase (5) · Leukemia, Myelomonocytic, Chronic (5) · Lymphoma, Large B-Cell, Diffuse (5) · Myeloproliferative Disorders (5) · Anemia, Refractory, with Excess of Blasts (4) · Hematologic Neoplasms (4) · Hodgkin Disease (4) · Leukemia, Lymphocytic, Chronic, B-Cell (4)
National Cancer Institute (NCI) (11) · Fred Hutchinson Cancer Center (9) · M.D. Anderson Cancer Center (5) · Children's Oncology Group (3) · University of Washington (3) · Roswell Park Cancer Institute (2) · Case Comprehensive Cancer Center (1) · ECOG-ACRIN Cancer Research Group (1) · Eastern Cooperative Oncology Group (1) · Fox Chase Cancer Center (1) · Northwestern University (1) · Stanford University (1)
United States (39) · Australia (5) · Canada (5) · Puerto Rico (5) · New Zealand (1)
Issa Khouri (2) · Marie Bleakley (2) · Anne Angiolillo (1) · Boglarka Gyurkocza (1) · David Ebb (1) · Elias Jabbour (1) · Elizabeth Plimack, MD (1) · Elizabeth Raetz, MD (1) · Eric J Lowe (1) · Farhad Ravandi-Kashani, MD (1) · Francisco Hernandez-ILizaliturri (1) · George Chen (1) · Georgiana Ellis (1) · H. Joachim Deeg (1) · Heather Wakelee (1)
PMID 35007144, PMID 20466853, PMID 24077846, PMID 24146219, PMID 24821881, PMID 25964296, PMID 28419486, PMID 29812996, PMID 30117142, PMID 30957229, PMID 31212080, PMID 31702432, PMID 32154021, PMID 32589978, PMID 33242441, PMID 33684925, PMID 34138471, PMID 34162404, PMID 34492682, PMID 35157306, PMID 35622074, PMID 36534942, PMID 38867582
U10CA098543 (8), P30CA015704 (5), U10CA180886 (4), P01HL036444 (3), U10CA031946 (3), P01CA018029 (2), R01HL121568 (2), U10CA180821 (2), K23CA154532 (1), P01CA044991 (1), P30CA016672 (1), P30CA046592 (1), P30CA060553 (1), U01CA097452 (1), U10CA021115 (1)