23 completed, 12 active not recruiting, 5 recruiting, 4 terminated. 22 Phase 2, 11 Phase 3, 4 Phase 1, 4 Phase 4, 1 Not applicable.
Follow Leuprorelin Acetate: new trials by email Literature Review of Leuprorelin Acetate trials Research Report on Leuprorelin Acetate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase Ia Trial of HHK001 Compared With Enantone in Patients With Endometriosis Leuprorelin Acetate, Leuprorelin Acetate 3.75mg Injection - Endometriosis | Phase 1 | Recruiting | Zhuhai Huahaikang Pharmaceutical Technology Co., Ltd. | 30 | 2026-08-31 | 2026-09-02 |
| Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial Abiraterone Acetate, Biospecimen Collection, Leuprolide Acetate - Recurrent Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 202 | 2026-08-04 | 2026-09-18 |
| A Clinical Study of KLH-2109 in Patients With Endometriosis KLH-2109, Leuprorelin acetate - Endometriosis | Phase 3 | Active not recruiting | Kissei Pharmaceutical Co., Ltd. | 288 | 2025-06-09 | 2026-03-02 |
| Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer Biopsy, Bone Scan, Computed Tomography - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Active not recruiting | Roswell Park Cancer Institute | 3 | 2024-12-19 | 2026-08-07 |
| Efficacy and Safety of DKF-MA102 in Patients With Prostate Cancer DKF-MA102 - Advanced Prostate Cancer | Phase 3 | Completed | Dongkook Pharmaceutical Co., Ltd. | 161 | 2024-05-30 | 2026-08-14 |
| Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors Biospecimen Collection, Chest Radiography, Computed Tomography - Adult Ovarian Granulosa Cell Tumor | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 17 | 2024-02-08 | 2026-07-28 |
| Testing the Anti-cancer Drug Darolutamide in Patients With Testosterone-Driven Salivary Gland Cancers Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Salivary Gland Carcinoma, Metastatic Salivary Gland Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 21 | 2023-07-20 | 2026-07-31 |
| Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer Abiraterone Acetate, Bicalutamide, Degarelix - Castration-Sensitive Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 70 | 2021-05-04 | 2026-01-28 |
| Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer Abiraterone Acetate, Apalutamide, Leuprolide Acetate - Metastatic Prostate Adenocarcinoma, Prostate Adenocarcinoma With Focal Neuroendocrine Differentiation | Phase 2 | Active not recruiting | Jonsson Comprehensive Cancer Center | 28 | 2021-03-17 | 2026-02-05 |
| Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study Darolutamide, Goserelin Acetate, Leuprolide Acetate - Prostate Carcinoma | Phase 3 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 27 | 2021-03-01 | 2026-07-28 |
| Androgen Deprivation Therapy and Apalutamide With or Without Radiation Therapy for the Treatment of Biochemically Recurrent Prostate Cancer, RESTART Study Apalutamide, Degarelix, Leuprolide Acetate - Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2020-11-24 | 2021-01-20 | |
| Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging 3-Dimensional Conformal Radiation Therapy, Apalutamide, Computed Tomography - Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 804 | 2020-10-08 | 2026-08-19 |
| Androgen Deprivation Therapy on Bone Mineral Density Change in Prostate Cancer Patients Leuprorelin, Goserelin, Triptorelin - Prostatic Neoplasms | Phase 4 | Unknown | Wonju Severance Christian Hospital | 164 | 2020-01-23 | 2021-07-29 |
| PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate Leuprorelin acetate, Letrozole, MammaPrint - Breast Cancer | Phase 2 | Active not recruiting | Seoul National University Hospital | 122 | 2019-11-08 | 2024-07-31 |
| Clinical Study to Evaluate Efficacy and Safety of TAK-385 40 mg Compared With Leuprorelin in Patients With Endometriosis TAK-385, Leuprorelin acetate - Endometriosis | Phase 3 | Completed | ASKA Pharmaceutical Co., Ltd. | 335 | 2019-05-08 | 2020-12-11 |
| Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer Abiraterone, Bicalutamide, Degarelix - Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 1273 | 2018-09-24 | 2026-10-08 |
| Radium Ra 223 Dichloride, Hormone Therapy and Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Prostate Cancer Leuprolide Acetate, Goserelin Acetate, Stereotactic Body Radiation Therapy - Prostate Adenocarcinoma | Phase 2 | Active not recruiting | City of Hope Medical Center | 25 | 2018-08-29 | 2026-04-09 |
| Role of Suppression of Endometriosis With Progestins Before IVF-ET Dienogest, leuprorelin acetate - IVF, Endometriosis | Not applicable | Completed | National Research Centre, Egypt | 134 | 2018-08-01 | 2020-08-05 |
| Study to Evaluate the Safety and Efficacy of Switching From Zoladex® Monthly or Quarterly, to Eligard® Semiannual. Leuprorelin Acetate (Eligard® 45 mg). - Prostate Cancer | Phase 4 | Completed | Zodiac Produtos Farmaceuticos S.A. | 48 | 2017-11-14 | 2022-03-31 |
| Specified Drug-Use Survey of Leuprorelin Acetate Injection Kit 11.25 mg "All-Case Investigation: Spinal and Bulbar Muscular Atrophy (SBMA)" Leuprorelin Acetate - Spinal and Bulbar Muscular Atrophy | Completed | Takeda | 1905 | 2017-11-02 | 2026-05-22 |
Showing 20 of 47. Sign in to see all of them.
Prostatic Neoplasms (22) · Endometriosis (8) · Breast Neoplasms (4) · Bulbo-Spinal Atrophy, X-Linked (1) · Granulosa cell tumor of the ovary (1) · Infertility (1) · Neoplasm Metastasis (1) · Pelvic Pain (1) · Puberty, Precocious (1) · Salivary Gland Neoplasms (1)
Takeda (8) · National Cancer Institute (NCI) (5) · City of Hope Medical Center (3) · Mayo Clinic (3) · Astellas Pharma Europe B.V. (2) · ECOG-ACRIN Cancer Research Group (2) · Kissei Pharmaceutical Co., Ltd. (2) · M.D. Anderson Cancer Center (2) · ASKA Pharmaceutical Co., Ltd. (1) · AbbVie (prior sponsor, Abbott) (1) · Astellas Pharma Europe Ltd. (1) · Astellas Pharma Inc (1) · Dongkook Pharmaceutical Co., Ltd. (1) · Jonsson Comprehensive Cancer Center (1) · NRG Oncology (1)
United States (22) · Japan (9) · Germany (3) · South Korea (3) · Belgium (2) · Canada (2) · France (2) · Hungary (2) · Puerto Rico (2) · Russia (2) · Australia (1) · Brazil (1) · Bulgaria (1) · Chile (1) · China (1)
Christopher Logothetis (2) · Alan L Ho (1) · Alicia K Morgans (1) · Amar Kishan (1) · Brian Chapin (1) · Bumjin Lim, M.D. (1) · Cheol Kwak, M.D.,Ph.D (1) · Choung-Soo Kim, M.D.,Ph.D (1) · Cy A Stein (1) · Eleni Efstathiou (1) · Elizabeth Hopp (1)
PMID 19017549, PMID 20818327, PMID 23127770, PMID 23151431, PMID 24926950, PMID 25130995, PMID 25847934, PMID 26072289, PMID 26520703, PMID 27799048, PMID 28552710, PMID 30579763, PMID 31067329, PMID 32912633, PMID 33784989, PMID 34154590, PMID 34895700, PMID 37166817, PMID 38421243, PMID 38494380, PMID 41065045, PMID 42070324, PMID 42150145, PMID 42574969
P30CA015083 (2), P30CA033572 (2), U10CA180820 (2), U10CA180868 (2), 2005 (1), 2016 (1), N01CM00039 (1), N01CM62202 (1), N01CM62205 (1), N01CM62206 (1), P30CA008748 (1), P30CA016672 (1), U01CA062461 (1), U01CA062491 (1), U10CA032102 (1)