14 completed, 1 terminated. 8 Phase 2, 4 Phase 1, 2 Phase 3, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 8 |
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
Follow Islet Transplantation: new trials by email Literature Review of Islet Transplantation trials Research Report on Islet Transplantation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant Alpha 1-Antitrypsin, Islet Transplantation, Thymoglobulin - Kidney Transplant, Type 1 Diabetes | Phase 2 | Completed | Massachusetts General Hospital | 2 | 2017-01-01 | 2023-12-22 |
| Nephrologic Prognosis 10 Years After Diabetes Cell Therapy islet transplanted, non islet transplanted - Islet Transplantation | Completed | University Hospital, Lille | 45 | 2014-11-03 | 2022-04-29 | |
| Allogeneic Islet Cells Transplanted Onto the Omentum Islet transplantation - Type 1 Diabetes Mellitus, Hypoglycemia | Phase 1 / Phase 2 | Completed | Rodolfo Alejandro | 3 | 2014-09-01 | 2025-08-12 |
| Islet After Kidney Transplantation (IAK) in Patients With Type 1 Diabetes Islet Transplantation, Islet cell transplantation - Diabetes Mellitus | Phase 1 | Completed | City of Hope Medical Center | 3 | 2008-10-18 | 2026-04-27 |
| Efficacy of Islet After Kidney Transplantation Islet transplantation, Antithymocyte Globulin, Daclizumab or Basiliximab - Type 1 Diabetes Mellitus | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 24 | 2007-01-01 | 2017-10-20 |
| Islet Transplantation in Type 1 Diabetes Allogeneic Pancreatic Islet Cells, Antithymocyte Globulin, Sirolimus - Type 1 Diabetes Mellitus | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 48 | 2006-10-01 | 2019-07-17 |
| Steroid-free and Long-term Calcineurin-free Trial in Islet Cell Transplantation Islet transplantation - Type 1 Diabetes Mellitus | Phase 2 | Completed | Rodolfo Alejandro | 3 | 2005-07-01 | 2017-05-25 |
| Islet of Langerhans Graft Monitoring by Magnetic Resonance Imaging ferucarbotran (iron-based MRI contrast agent), Islet transplantation, Magnetic resonance imaging - Type 1 Diabetes Mellitus | Phase 1 | Terminated | University Hospital, Geneva | 5 | 2005-06-01 | 2014-12-02 |
| Islet Transplantation for Patients With Type 1 Diabetes Islet transplantation - Diabetes Mellitus, Type 1 | Phase 1 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 10 | 2003-08-01 | 2010-01-15 |
| Islet Allotransplantation With Steroid Free Immunosuppression islet transplantation, daclizumab - sirolimus - tacrolimus - Type 1 Diabetes, Hypoglycemia | Phase 2 | Completed | University Hospital, Lille | 14 | 2003-05-01 | 2012-04-27 |
| Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation islet transplantation - Type 1 Diabetes, Organ Transplantation | Not applicable | Completed | University Hospital, Lille | 14 | 2003-03-01 | 2025-11-28 |
| Islet Transplantation for Type 1 Diabetes Islet Transplantation, Sirolimus, Tacrolimus - Diabetes Mellitus, Insulin-Dependent | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 36 | 2001-04-01 | 2017-03-15 |
| Islet Cell Transplantation Alone in Patients With Type 1 Diabetes Mellitus: Steroid-Free Immunosuppression islets - Diabetes Mellitus, Type I | Phase 2 | Completed | Rodolfo Alejandro | 26 | 2000-12-01 | 2024-11-04 |
| Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation Islet Transplantation - Diabetes Mellitus, Type 1 | Phase 2 | Completed | Rodolfo Alejandro | 7 | 2000-12-01 | 2017-04-12 |
| Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression Islet Transplantation - Diabetes Mellitus Type 1 | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 6 | 2000-11-16 | 2021-04-20 |
Diabetes Mellitus, Type 1 (13) · Hypoglycemia (5) · Diabetes Mellitus (4) · Autoimmune Diseases (1) · Metabolic Diseases (1)
Rodolfo Alejandro (4) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · University Hospital, Lille (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · City of Hope Medical Center (1) · Massachusetts General Hospital (1) · University Hospital, Geneva (1)
United States (11) · Canada (3) · France (3) · Switzerland (2) · Germany (1) · Italy (1)
Rodolfo Alejandro, M.D. (3) · James Shapiro, MD, PhD (2) · Ali Naji, PhD (1) · Andrew Posselt, MD, PhD (1) · Bernhard Hering, MD (1) · Camillo Ricordi, M.D. (1) · Camillo Ricordi, MD (1) · Fouad Kandeel, MD (1) · Francois Pattou, MD (1) · James F. Markmann, MD, PhD (1) · Jim Markmann, M.D. Ph.D. (1) · Julie Kerr-Conte, PhD (1)
PMID 19005394, PMID 20003758, PMID 22996144, PMID 23438305, PMID 25393157, PMID 28941330, PMID 31615852, PMID 15257060, PMID 15996257, PMID 17005949, PMID 18360260, PMID 19104407, PMID 19418039, PMID 19638525, PMID 20660050, PMID 23630300, PMID 25629445, PMID 27208344, PMID 27465220, PMID 29563196, PMID 29654388
R01DK025802 (1), R01DK055347 (1), U42RR016603 (1)