56 completed, 17 terminated, 6 withdrawn, 5 active not recruiting. 47 Phase 2, 25 Phase 1, 18 Phase 3, 3 Early Phase 1, 3 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Thermosensitive Gel Nasal Spray With Exosomes, Azelastine, and Interferon for Acute Phase of Chronic Sinusitis Exosomes, Azelastine, and Interferon alpha-2b, Azelastine and Interferon alpha-2b, Placebo Gel Matrix - Chronic Rhinosinusitis Without Polyps | Early Phase 1 | Not yet recruiting | The First Affiliated Hospital of Xinxiang Medical College | 108 | 2026-07-01 | 2026-06-09 |
| Polarized Dendritic Cell (aDC1) Based Treatment, Interferon Alpha-2, Rintatolimod, and Celecoxib for the Treatment of HLA-A2+ Refractory Melanoma Alpha-type-1 Polarized Dendritic Cells, Celecoxib, PD-1 Ligand Inhibitor - HLA-A2 Positive Cells Present, Refractory Melanoma | Phase 2 | Terminated | Roswell Park Cancer Institute | 1 | 2024-11-13 | 2026-02-25 |
| Evaluate the Efficacy and Safety of Interferon-α Combined With ATO in the Treatment of Arsenic-resistant APL interferon α-2b - Tumour | Not applicable | Unknown | Zhejiang Provincial People's Hospital | 15 | 2024-05-01 | 2024-06-10 |
| Rintatolimod and IFN Alpha-2b for the Treatment of COVID-19 in Cancer Patients Recombinant Interferon Alfa-2b, Rintatolimod - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Terminated | Roswell Park Cancer Institute | 4 | 2020-11-17 | 2026-01-13 |
| Chemokine Modulation Therapy and Standard Chemotherapy Before Surgery for the Treatment of Early Stage Triple Negative Breast Cancer Celecoxib, Cyclophosphamide, Doxorubicin - Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | Phase 1 | Completed | Roswell Park Cancer Institute | 9 | 2019-12-06 | 2023-09-11 |
| Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery EC Aspirin, Radical Prostatectomy, Recombinant Interferon Alfa-2b - Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Phase 2 | Active not recruiting | Roswell Park Cancer Institute | 12 | 2019-11-29 | 2026-06-09 |
| Chemokine Modulation Therapy and Pembrolizumab in Treating Participants With Metastatic Triple-Negative Breast Cancer Biopsy, Chemokine Modulation Therapy, Celecoxib - Triple -Negative Breast Cancer, Estrogen Receptor Negative | Early Phase 1 | Completed | Roswell Park Cancer Institute | 8 | 2019-01-09 | 2023-07-18 |
| Celecoxib, Recombinant Interferon Alfa-2b, and Rintatolimod in Treating Patients With Colorectal Cancer Metastatic to the Liver Celecoxib, Laboratory Biomarker Analysis, Recombinant Interferon Alfa-2b - Metastatic Carcinoma in the Liver, Recurrent Colorectal Carcinoma | Phase 2 | Completed | Roswell Park Cancer Institute | 19 | 2018-04-19 | 2022-03-02 |
| The Study of JS001 Compared to High-Dose Interferon In Patients With Mucosal Melanoma That Has Been Removed by Surgery humanized anti-PD-1 monoclonal antibody Toripalimab, high-dose recombinant interferon a-2B - Mucosal Melanoma | Phase 2 | Terminated | Shanghai Junshi Bioscience Co., Ltd. | 6 | 2017-05-31 | 2026-07-27 |
| SV-BR-1-GM in Metastatic or Locally Recurrent Breast Cancer SV-BR-1-GM, Cyclophosphamide, Interferon-alpha-2b - Breastcancer, Breast Neoplasm | Phase 1 / Phase 2 | Completed | BriaCell Therapeutics Corporation | 24 | 2017-05-05 | 2021-01-29 |
| Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma Belinostat, Zidovudine, Interferon-Alfa-2b - Adult T-cell Leukemia-Lymphoma, ATLL | Phase 2 | Completed | University of Miami | 15 | 2016-12-12 | 2026-03-10 |
| Study of Recombinant Human Serum Albumin/Interferon alpha2b Fusion Protein in Chinese Healthy Volunteers Human Serum Albumin/interferon alpha2b, Peginterferon 180 μg single dose S.C. - Healthy | Phase 1 | Completed | Tianjin SinoBiotech Ltd. | 34 | 2016-04-07 | 2017-05-08 |
| A Study of Type-1 Polarized Dendritic Cell (αDC1) Vaccine in Combination With Tumor-Selective Chemokine Modulation (Interferon-α2b, Rintatolimod, and Celecoxib) in Subjects With Chemo-Refractory Metastatic Colorectal Cancer αDC1 vaccine, CKM - Metastatic Colorectal Cancer | Phase 2 | Withdrawn | Pawel Kalinski | 2016-03-01 | 2017-09-26 | |
| Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery Biospecimen Collection, Computed Tomography, Ipilimumab - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8 | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 1301 | 2015-11-10 | 2026-11-13 |
| Neoadjuvant Combination Biotherapy With Pembrolizumab and High Dose IFN-alfa2b Pembrolizumab and high dose interferon alfa-2b (HDI) - Melanoma | Phase 1 | Completed | Yana Najjar | 31 | 2015-03-06 | 2021-02-24 |
| Randomized Phase III of PRRT Versus Interferon Interferon alpha-2b, 177Lu-DOTATATE - Gastro-intestinal Neuroendocrine Tumors | Phase 3 | Withdrawn | Jules Bordet Institute | 2014-12-01 | 2016-04-05 | |
| IFN-DLI for Relapsed Acute Leukemia After Allo-SCT Interferon alpha-2B (IFN-α) 3 million units (MU) subcutaneous daily - Leukemia | Early Phase 1 | Completed | Abramson Cancer Center at Penn Medicine | 16 | 2014-12-01 | 2020-04-21 |
| αDC1 Vaccine + Chemokine Modulatory Regimen (CKM) as Adjuvant Treatment of Peritoneal Surface Malignancies DC vaccine, Celecoxib, Interferon Alfa-2b - Malignant Neoplasm of Pancreas Metastatic to Peritoneal Surface, Malignant Peritoneal Mesothelioma | Phase 1 / Phase 2 | Completed | David Bartlett | 64 | 2014-07-01 | 2020-07-20 |
| Comparison of Methotrexate Versus Interferon-alfa 2b in Patients With Primary Cutaneous T-cell Lymphomas Methotrexate, Interferon Alfa-2b - Lymphoma, T-Cell, Cutaneous, Mycosis Fungoides | Phase 4 | Terminated | Polish Lymphoma Research Group | 100 | 2014-06-01 | 2022-01-13 |
| Topical Interferon Alfa 2b and Mitomycin C in Conjunctival-Corneal Intraepithelial Neoplasia Mitomycin C, Interferon Alfa-2b - Conjunctival Intraepithelial Neoplasia, Corneal Intraepithelial Neoplasia | Phase 4 | Completed | Coordinación de Investigación en Salud, Mexico | 18 | 2014-05-01 | 2017-08-08 |
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Melanoma (33) · Carcinoma, Renal Cell (11) · Neoplasm Metastasis (6) · Neoplasms (6) · Recurrence (5) · Carcinoma, Hepatocellular (4) · Hepatitis C (4) · Multiple Myeloma (4) · Colorectal Neoplasms (3) · Hepatitis C, Chronic (3) · Leukemia (3) · Breast Neoplasms (2) · Hematologic Neoplasms (2) · Kidney Neoplasms (2) · Liver Neoplasms (2)
National Cancer Institute (NCI) (13) · M.D. Anderson Cancer Center (10) · Roswell Park Cancer Institute (7) · Case Comprehensive Cancer Center (3) · Merck Sharp & Dohme LLC (3) · Endocyte (2) · Foundation for Liver Research (2) · Kyoto University (2) · Peking University Cancer Hospital & Institute (2) · The Methodist Hospital Research Institute (2) · Abramson Cancer Center at Penn Medicine (1) · Aga Khan University (1) · Alliance for Clinical Trials in Oncology (1) · BriaCell Therapeutics Corporation (1) · California Pacific Medical Center Research Institute (1)
United States (63) · Canada (6) · China (5) · Japan (2) · Netherlands (2) · Australia (1) · Belgium (1) · France (1) · Germany (1) · Ireland (1) · Italy (1) · Mexico (1) · Pakistan (1) · Poland (1) · Puerto Rico (1)
Ahmad Tarhini (2) · Ernest C. Borden, MD (2) · Igor Puzanov (2) · John M. Kirkwood, MD (2) · Nicholas E. Papadopoulos, MD (2) · Richard A Messmann, MD, MHS, BSc (2) · Robert J Amato, DO (2) · Rodabe N. Amaria, MD (2) · William Carson (2) · Agop Y. Bedikian, MD,BS (1) · Alberto Pappo, MD (1) · Alberto S. Pappo, MD (1) · Alvarado Beatriz, M.D. (1) · Amer H Zureikat, MD (1)
PMID 16525139, PMID 17133492, PMID 18317583, PMID 20063546, PMID 20670978, PMID 21256809, PMID 22689675, PMID 22755276, PMID 22975216, PMID 25649350, PMID 25832001, PMID 25900027, PMID 26503196, PMID 27581518, PMID 28384065, PMID 28489678, PMID 31014399, PMID 31371315, PMID 32632956, PMID 35659704, PMID 36029412, PMID 36416836, PMID 36848607, PMID 37146227, PMID 40471585, PMID 40501401
U10CA021115 (3), P01CA234212 (2), P30CA016672 (2), P50CA121973 (2), U10CA032102 (2), U10CA180820 (2), U10CA180888 (2), U24CA196172 (2), 2009 (1), N01CM17101 (1), N01CM62202 (1), P01CA132714 (1), P30CA016056 (1), P30CA016058 (1), P30CA033572 (1)