22 terminated. 22 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 22 | Terminated 22 |
| Phase 2 | 5 | Terminated 5 |
Follow Hydroxychloroquine: new trials by email Literature Review of Hydroxychloroquine trials Research Report on Hydroxychloroquine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metabolic Cofactor Supplementation and Hydroxychloroquine Combination in Covid-19 Patients Hydroxychloroquine + Metabolic cofactor supplementation, Hydroxychloroquine + Sorbitol - COVID-19 | Phase 2 / Phase 3 | Terminated | ScandiBio Therapeutics AB | 100 | 2020-09-21 | 2025-02-10 |
| Hydroxychloroquine as Post-Exposure Prophylaxis Against COVID-19 Infection Hydroxychloroquine, Vitamin D - COVID-19, SARS-CoV 2 | Phase 3 | Terminated | Sanford Health | 1 | 2020-05-14 | 2021-12-10 |
| Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial Azithromycin, Hydroxychloroquine, Placebo - COVID-19, Respiratory Failure | Phase 3 | Terminated | Frantisek Duska, MD, PhD | 3 | 2020-05-13 | 2020-11-06 |
| Does Hydroxychloroquine Before & During Patient Exposure Protect Healthcare Workers From Coronavirus? Hydroxychloroquine, Placebo oral tablet - Pre-Exposure Prophylaxis, Coronavirus | Phase 3 | Terminated | Megan Landes | 13 | 2020-04-30 | 2021-04-29 |
| Efficacy of Hydroxychloroquine, Telmisartan and Azithromycin on the Survival of Hospitalized Elderly Patients With COVID-19 Hydroxychloroquine, Azithromycin, Telmisartan - COVID-19 Infection | Phase 3 | Terminated | University Hospital, Strasbourg, France | 16 | 2020-04-25 | 2022-07-11 |
| Trial of Hydroxychloroquine In Covid-19 Kinetics Hydroxychloroquine, Placebo - Covid 19, Corona Virus Infection | Phase 2 / Phase 3 | Terminated | University of South Alabama | 3 | 2020-04-17 | 2022-01-03 |
| Dexamethasone Treatment for Severe Acute Respiratory Distress Syndrome Induced by COVID-19 Dexamethasone and Hydroxychloroquine, Hydroxychloroquine - Respiratory Distress Syndrome, Adult, COVID-19 | Phase 3 | Terminated | Centre Chirurgical Marie Lannelongue | 5 | 2020-04-17 | 2021-08-12 |
| Treatment for COVID-19 in High-Risk Adult Outpatients Ascorbic Acid, Hydroxychloroquine Sulfate, Azithromycin - COVID-19, SARS-CoV-2 | Phase 2 / Phase 3 | Terminated | University of Washington | 289 | 2020-04-16 | 2022-08-08 |
| Chemoprophylaxis of SARS-CoV-2 Infection (COVID-19) in Exposed Healthcare Workers Hydroxychloroquine, Placebo of Hydroxychloroquine, Lopinavir and ritonavir - COVID-19 | Phase 3 | Terminated | Centre Hospitalier Universitaire de Saint Etienne | 118 | 2020-04-14 | 2023-03-01 |
| ALBERTA HOPE COVID-19 for the Prevention of Severe COVID19 Disease Hydroxychloroquine - COVID-19 | Phase 3 | Terminated | Dr. Michael Hill | 148 | 2020-04-13 | 2020-07-31 |
| Treatment in Patients With Suspected or Confirmed COVID-19 With Early Moderate or Severe Disease Hydroxychloroquine, Azithromycin - COVID-19 | Phase 3 | Terminated | LCMC Health | 22 | 2020-04-13 | 2022-01-21 |
| Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for COVID-19 Pneumonia (COVIDOC Trial) Hydroxychloroquine + placebo, hydroxychloroquine + azithromycin - Coronavirus Infection, Pneumonia, Viral | Phase 2 / Phase 3 | Terminated | University Hospital, Montpellier | 7 | 2020-04-11 | 2021-12-15 |
| Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection Hydroxychloroquine Sulfate, Azithromycin, Chloroquine Sulfate - Coronavirus Infection | Phase 3 | Terminated | Washington University School of Medicine | 30 | 2020-04-04 | 2024-04-25 |
| Evaluation of the Pharmacokinetics and Pharmacodynamics of Hydroxychloroquine in COVID-19 Intensive Care Unit Patients Hydroxychloroquine (HCQ) - Sars-CoV2 | Phase 3 | Terminated | Centre Hospitalier Universitaire de Saint Etienne | 7 | 2020-04-03 | 2020-09-07 |
| Hydroxychloroquine Versus Placebo in COVID-19 Patients at Risk for Severe Disease Hydroxychloroquine, Placebo - Coronavirus | Phase 3 | Terminated | University Hospital, Angers | 259 | 2020-04-01 | 2020-10-06 |
| Hydroxychloroquine for COVID-19 Hydroxychloroquine Sulfate, Placebo - COVID-19, Hydroxychloroquine Sulfate | Phase 3 | Terminated | University Hospital Tuebingen | 30 | 2020-03-29 | 2021-05-03 |
| Hydroxychloroquine Post Exposure Prophylaxis for Coronavirus Disease (COVID-19) Hydroxychloroquine, Placebo oral tablet - COVID-19, Corona Virus Infection | Phase 2 / Phase 3 | Terminated | Columbia University | 10 | 2020-03-29 | 2024-09-25 |
| A Randomized Controlled Clinical Trial: Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Patients Hydroxychloroquine - COVID-19 | Phase 3 | Terminated | Queen's Medical Center | 17 | 2020-03-26 | 2026-02-06 |
| Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada) Hydroxychloroquine, Placebo oral tablet - Corona Virus Infection, SARS-CoV Infection | Phase 3 | Terminated | McGill University Health Centre/Research Institute of the McGill University Health Centre | 70 | 2020-03-25 | 2024-10-15 |
| Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate Monotherapy Methotrexate, Leflunomide, Hydroxychloroquine - Rheumatoid Arthritis | Phase 3 | Terminated | Jawaharlal Institute of Postgraduate Medical Education & Research | 136 | 2016-09-01 | 2021-07-27 |
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COVID-19 (17) · Coronavirus Infections (7) · Pneumonia (2) · Pneumonia, Viral (2) · Antiphospholipid Syndrome (1) · Arthritis, Rheumatoid (1) · Lupus Erythematosus, Systemic (1) · Respiratory Distress Syndrome (1) · Respiratory Insufficiency (1) · Severe Acute Respiratory Syndrome (1) · Thrombocytopenia (1)
Centre Hospitalier Universitaire de Saint Etienne (2) · Centre Chirurgical Marie Lannelongue (1) · Chinese SLE Treatment And Research Group (1) · Columbia University (1) · Dr. Michael Hill (1) · Frantisek Duska, MD, PhD (1) · Hospital for Special Surgery, New York (1) · Jawaharlal Institute of Postgraduate Medical Education & Research (1) · LCMC Health (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Megan Landes (1) · Queen's Medical Center (1) · Sanford Health (1) · ScandiBio Therapeutics AB (1) · University Hospital Tuebingen (1)
United States (9) · France (6) · Canada (3) · China (1) · Czechia (1) · Germany (1) · India (1) · Monaco (1) · Turkey (Türkiye) (1)
Bruno Hoen, MD, PhD (1) · Christine Johnston, MD, MPH (1) · Doruk Erkan, MD (1) · Elisabeth Botelho-Nevers, MD, PhD (1) · Jane O'Halloran, MD PhD (1) · Jon T. Giles, MD (1) · Kevin Kain, MD (1) · Luanne Metz, MD (1) · Megan Landes, MD (1) · Meredith Clement, MD (1)
PMID 11824975, PMID 15803929, PMID 21325604, PMID 21503695, PMID 2334081, PMID 23462431, PMID 24254965, PMID 32492293, PMID 32641163, PMID 32673060, PMID 33570583, PMID 33681731, PMID 33813110, PMID 34145052, PMID 34473343, PMID 34586472, PMID 35604806, PMID 37553227, PMID 8489547