9 completed, 8 unknown, 4 recruiting, 2 terminated. 17 Phase 2, 6 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 7, Unknown 6, Active not recruiting 1, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 6 | Recruiting 3, Unknown 2, Completed 1 |
| Phase 4 | 1 | Terminated 1 |
Follow FOLFOXIRI: new trials by email Literature Review of FOLFOXIRI trials Research Report on FOLFOXIRI
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer FOLFOXIRI, CAPOX, FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) - Locally Advanced Rectal Carcinoma | Phase 3 | Recruiting | J. W. A. Burger | 394 | 2026-03-16 | 2026-10-27 |
| CtDNA in Adjuvant Chemotherapy of Stage III Colon Cancer (REVISE Trial) FOLFOXIRI, XELOX - Colon Cancer | Phase 2 | Recruiting | West China Hospital | 60 | 2024-03-25 | 2024-12-12 |
| Circulating Tumor DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II-III FOLFOXIRI, CAPOX - Colorectal Neoplasms Malignant, Minimal Residual Disease | Phase 2 | Active not recruiting | Fundación para la Investigación del Hospital Clínico de Valencia | 45 | 2022-01-01 | 2026-09-15 |
| Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer FOLFOXIRI, CapeOX - Rectal Cancer | Phase 3 | Recruiting | Fudan University | 300 | 2021-08-27 | 2022-03-04 |
| FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer Liver Metastases Cetuximab, Bevacizumab, FOLFOXIRI - Liver Metastasis Colon Cancer | Phase 2 | Unknown | Fudan University | 160 | 2021-04-17 | 2021-04-06 |
| Organ Preservation Program Using Short-Course Radiation & FOLFOXIRI in Rectal Cancer FOLFOXIRI, FOLFOX regimen, XELOX - Rectal Cancer | Phase 2 | Completed | Stanford University | 38 | 2020-05-21 | 2025-02-25 |
| Brazilian Total Neoadjuvant Therapy Trial Folfirinox - Colorectal Neoplasms | Phase 3 | Unknown | Hospital Israelita Albert Einstein | 150 | 2020-02-20 | 2023-10-11 |
| Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation FOLFOXIRI, XELOX, Chemoradiotherapy - Rectal Cancer | Phase 3 | Recruiting | Sun Yat-sen University | 776 | 2018-11-16 | 2019-01-23 |
| Neoadjuvant FOLFOXIRI Chemotherapy in Resectable Liver Metastasis of Colorectal Cancer FOLFOXIRI - Colorectal Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-05-01 | 2021-04-19 |
| Neoadjuvant FOLFOXIRI Chemotherapy in Patients With Locally Advanced Colon Cancer FOLFOXIRI - Colonic Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-04-01 | 2021-04-19 |
| Totally Neoadjuvant FOLFOXIRI + Short-course Radiation + XELOX in Patients With Locally Advanced Rectal Cancer FOLFOXIRI, Short-Course Radiation Therapy(5Gy*5), XELOX - Rectal Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-04-01 | 2021-04-14 |
| FOLFOXIRI Chemotherapy Alone as Neoadjuvant Treatment for Circumferential Radial Margin (CRM) Positive Rectal Cancer FOLFOXIRI - Rectal Cancer | Phase 2 | Withdrawn | Guangxi Medical University | 2017-08-11 | 2019-08-08 | |
| Chemotherapy Intensification in Patients With High Lactate Dehydrogenase Values and Soluble Syndecan1 Levels FOLFOXIRI, FOLFOX, FOLFIRI - Metastatic Colorectal Cancer | Phase 2 | Terminated | Centre Hospitalier Universitaire de Besancon | 54 | 2017-08-04 | 2025-02-05 |
| Research on the Treatment of Metastatic Colon Cancer Patients Treated by FOLFOXIRI FOLFOXIRI - Colorectal Cancer | Completed | Hanoi Medical University | 39 | 2017-01-01 | 2018-04-20 | |
| Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer FOLFOXIRI - Rectal Cancer | Phase 2 | Unknown | RenJi Hospital | 100 | 2016-11-01 | 2018-01-03 |
| Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer FOLFOXIRI - Locally Advanced Rectal Cancer | Phase 2 | Completed | Aiping Zhou | 50 | 2016-02-06 | 2021-02-01 |
| FOLFOXIRI With or Without Bevacizumab as First-line Treatment for Unresectable Liver-only Metastatic Colorectal Cancer Patients With RAS Mutation-type FOLFOXIRI + Bevacizumab, FOLFOXIRI - Metastatic Colorectal Cancer | Phase 2 | Completed | Sun Yat-sen University | 138 | 2015-01-01 | 2026-05-22 |
| Italian Multicenter Study Comparing FOLFOXIRI Versus Gemcitabine as Adjuvant Treatment for Resected Pancreatic Cancer FOLFOXIRI, Gemcitabine - Pancreatic Cancer | Phase 3 | Unknown | Azienda Ospedaliero, Universitaria Pisana | 310 | 2015-01-01 | 2015-02-04 |
| Neoadjuvant FOLFOXIRI Chemotherapy Alone for Locally Advanced Rectal Cancer FOLFOXIRI - Rectal Cancer | Phase 2 | Completed | Sun Yat-sen University | 100 | 2014-08-15 | 2021-04-14 |
| FOLFOXIRI Compared to FOLFOX in First Line Treatment of Metastatic Colorectal Cancer FOLFOXIRI, FOLFOX - Metastatic Colorectal Cancer | Phase 2 | Unknown | Sun Yat-sen University | 162 | 2014-04-01 | 2014-05-07 |
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Colorectal Neoplasms (9) · Rectal Neoplasms (9) · Colonic Neoplasms (4) · Pancreatic Neoplasms (2) · Neoplasm Metastasis (1) · Neoplasm, Residual (1) · Neoplastic Cells, Circulating (1) · Pathologic Complete Response (1)
Sun Yat-sen University (5) · China Medical University, China (3) · Azienda Ospedaliero, Universitaria Pisana (2) · Fudan University (2) · AIO-Studien-gGmbH (1) · Aiping Zhou (1) · Centre Hospitalier Universitaire de Besancon (1) · Fundación para la Investigación del Hospital Clínico de Valencia (1) · Gruppo Oncologico del Nord-Ovest (1) · Guangxi Medical University (1) · Hanoi Medical University (1) · Hospital Israelita Albert Einstein (1) · Hospital Universitari de Bellvitge (1) · J. W. A. Burger (1) · RenJi Hospital (1)
China (14) · Italy (3) · Spain (2) · Brazil (1) · France (1) · Germany (1) · Netherlands (1) · United States (1) · Vietnam (1)
Yanhong Deng, M.D. (3) · Jingdong Zhang (2) · Aiping Zhou, Doctor (1) · Alfredo Falcone, MD (1) · Carlos Moreno Sanz (1) · Diogo Gomes, MD (1) · Eduardo Targarona Soler (1) · Enrico Vasile, MD, PhD (1) · Erqi L Pollom (1)
PMID 26861604, PMID 28497402, PMID 31609637, PMID 35834598, PMID 37370032, PMID 38412408, PMID 38902952, PMID 39753246, PMID 42151882, PMID 42743885
2009 (1), 2025 (1)