5 completed, 3 unknown, 1 recruiting, 1 suspended. 11 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 5, Unknown 3, Recruiting 1, Suspended 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 1, Suspended 1 |
Follow D-serine: new trials by email Literature Review of D-serine trials Research Report on D-serine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| D-SPARK: A Clinical Trial of D-Serine for Modifying Parkinson's Disease Progression D-serine, Placebo - Parkinson s Disease, Parkinson Disease (PD) | Phase 2 | Recruiting | Haukeland University Hospital | 100 | 2026-01-20 | 2026-06-04 |
| D-serine AudRem: R33 Phase D-serine, Placebo - Schizophrenia, Schizo Affective Disorder | Phase 1 / Phase 2 | Suspended | New York State Psychiatric Institute | 60 | 2022-12-01 | 2026-04-29 |
| D-serine Augmentation of Neuroplasticity D-serine, Placebo - Schizophrenia, Schizo Affective Disorder | Phase 1 / Phase 2 | Completed | New York State Psychiatric Institute | 45 | 2019-03-13 | 2022-06-14 |
| D-serine and Cognitive Remediation in Schizophrenia D-serine - Schizophrenia | Phase 2 | Completed | Nathan Kline Institute for Psychiatric Research | 8 | 2014-08-01 | 2020-10-08 |
| D-Serine for Cocaine Dependence Pilot D-serine, Cognitive Behavioral Therapy, Placebo - Cocaine Dependence | Phase 2 | Withdrawn | Theresa Winhusen | 2014-02-01 | 2014-02-06 | |
| N-methyl-D-aspartic Acid (NMDA) and Cognitive Remediation in Schizophrenia D-serine, placebo, Sensory Based remediation paradigm - Schizophrenia, Schizoaffective Disorder | Phase 2 | Unknown | Nathan Kline Institute for Psychiatric Research | 16 | 2012-03-01 | 2012-10-25 |
| High Dose D-Serine as Adjuvant Treatment for Recent Onset Schizophrenia D-serine - Schizophrenia | Phase 2 | Unknown | Hadassah Medical Organization | 54 | 2011-11-01 | 2011-10-25 |
| D-serine for the Schizophrenia Prodrome D-serine, Placebo - Schizophrenia Prodrome | Phase 2 | Completed | Nathan Kline Institute for Psychiatric Research | 44 | 2009-03-01 | 2017-08-14 |
| D-serine Monotherapy for Schizophrenia D-serine, Olanzapine - Schizophrenia | Phase 2 | Completed | Herzog Hospital | 18 | 2009-01-01 | 2013-12-10 |
| Safety and Effectiveness of D-serine in Schizophrenia D-serine - Schizophrenia | Phase 2 | Completed | Nathan Kline Institute for Psychiatric Research | 55 | 2006-03-01 | 2020-10-05 |
| Israel Multicenter D-Serine Study (IMSER) for the Treatment of Schizophrenia D-serine - Schizophrenia, Schizoaffective Disorder | Phase 2 | Unknown | Sheba Medical Center | 200 | 2004-10-01 | 2006-12-27 |
Schizophrenia (9) · Psychotic Disorders (4) · Cocaine-Related Disorders (1) · Parkinson Disease (1) · Substance-Related Disorders (1)
Nathan Kline Institute for Psychiatric Research (4) · New York State Psychiatric Institute (2) · Hadassah Medical Organization (1) · Haukeland University Hospital (1) · Herzog Hospital (1) · Sheba Medical Center (1) · Theresa Winhusen (1)
United States (7) · Israel (3) · Norway (1)
Joshua T Kantrowitz, MD (2) · Amit Lotan, MD (1) · Bernard Lerer, MD (1) · Daniel C Javitt, MD, PhD (1) · Daniel C. Javitt, MD, PhD (1) · Mark Weiser, MD (1) · Uriel Heresco-Levy, MD (1)
PMID 22795211, PMID 26360284, PMID 27913408, PMID 28318835, PMID 36958998, PMID 37293030, PMID 37690312
U01MH074356 (1)