17 completed, 6 recruiting, 5 unknown, 3 active not recruiting. 18 Phase 2, 7 Phase 1, 4 Not applicable, 4 Phase 3, 2 Early Phase 1.
Follow Cytoreductive surgery: new trials by email Literature Review of Cytoreductive surgery trials Research Report on Cytoreductive surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intensive Locoregional Chemoimmunotherapy, Intradermal Autologous Alpha-DC1 Vaccines, and Systemic Pembrolizumab for Advanced-Stage Ovarian Cancer Paclitaxel, Cisplatin, Bioferon - Ovarian Cancer | Phase 2 | Not yet recruiting | Kalinski, Pawel, MD, PhD | 28 | 2026-10-01 | 2026-10-13 |
| Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer Mitomycin (MM), FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin), Cytoreductive surgery - Locally Advanced Colorectal Cancer | Phase 3 | Recruiting | Maimónides Biomedical Research Institute of Córdoba | 1083 | 2026-05-26 | 2026-06-08 |
| Primary Tumor Resection With Sintilimab and Chemotherapy in Advanced NSCLC Cytoreductive surgery, Immunochemotherapy - Non Small Cell Lung Cancer | Phase 2 | Not yet recruiting | Jianxing He | 118 | 2025-09-10 | 2025-09-16 |
| Personalised Timing of Interval Debulking Surgery in Advanced Ovarian Cancer KELIM, Carboplatin plus Paclitaxel, Interval debulking surgery - Ovarian Cancer, Fallopian Tube Cancer | Phase 2 | Recruiting | The University of Hong Kong | 18 | 2024-05-28 | 2025-07-02 |
| Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin Cytoreductive surgery, LMB-100, Immunohistochemical Assay for Mesothelin - Malignant Pleural Mesotheliomas (Mpm), Malignant Pleural Effusions (Mpe) | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2024-01-31 | 2024-02-02 | |
| SUROVA - Surgery in Ovarian Cancer, Comparing Primary and Interval Cytoreductive Surgery Cytoreductive surgery, Neoadjuvant chemotherapy, Adjuvant chemotherapy - Epithelial Ovarian Cancer, Fallopian Tube Neoplasms | Unknown | Clinica Universidad de Navarra, Universidad de Navarra | 5000 | 2024-01-01 | 2024-01-25 | |
| Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer Carboplatin or cisplatin, Paclitaxel, gemcitabine or liposomal doxorubicin with or without bevacizumab or biosimilar, Bevacizumab or biosimilar - Recurrent Ovarian Carcinoma | Not applicable | Recruiting | The University of Hong Kong | 18 | 2023-11-01 | 2025-06-11 |
| Validation of ESGO Quality Indicators in Advanced Ovarian Cancer Surgery Preoperative Evaluations, Cytoreductive Surgery, Perioperative Management - D010051, Ovarian Cancer | Completed | European Society of Gynaecological Oncology | 11383 | 2023-04-26 | 2026-05-05 | |
| Preoperative PRRT Versus Surgical Cytoreduction in Metastatic Pancreatic Neuroendocrine Tumors to the Liver cytoreductive surgery, Lutathera - a small molecule used in Peptide Receptor Radionuclide Therapy (PRRT), Peptide receptor radionuclide therapy (PRRT) - Pancreatic Neuroendocrine Tumor, Pancreas Cancer | Phase 1 / Phase 2 | Withdrawn | University of Chicago | 2023-03-07 | 2024-10-26 | |
| Cytoreductive Surgery in Platinum-resistant Recurrent Ovarian Cancer cytoreductive surgery - Cytoreductive Surgery | Not applicable | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 140 | 2022-12-01 | 2022-12-01 |
| Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer Cytoreductive surgery - Ovarian Cancer, Low Anterior Resection Syndrome | Recruiting | Seoul National University Hospital | 108 | 2022-06-22 | 2023-06-27 | |
| Hyperthermic Intraperitoneal Chemotherapy With Cisplatin During Surgery or Cisplatin Before Surgery for the Treatment of Stage III or IV Ovarian, Fallopian Tube or Peritoneal Cancer Carboplatin, Cisplatin, Cytoreductive Surgery - Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma | Early Phase 1 | Active not recruiting | Ohio State University Comprehensive Cancer Center | 35 | 2022-06-13 | 2026-08-17 |
| Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma Atezolizumab, Bevacizumab, Biospecimen Collection - Peritoneal Malignant Mesothelioma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 66 | 2022-03-22 | 2026-10-26 |
| Secondary Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Recurrent Mucinous Ovarian Cancer (HI-MOC Study) Cytoreductive surgery - Ovarian Cancer | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 30 | 2022-01-07 | 2026-10-07 |
| CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine Leiomyosarcoma Gemcitabine, Dacarbazine, Cytoreductive Surgery - LMS - Leiomyosarcoma, Uterine Leiomyosarcoma | Phase 2 | Completed | Stanford University | 17 | 2021-01-28 | 2026-06-25 |
| Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients Cisplatin, Cytoreductive Surgery, Doxorubicin - Malignant Abdominal Neoplasm, Malignant Pelvic Neoplasm | Early Phase 1 | Terminated | Mayo Clinic | 2 | 2019-11-08 | 2025-02-20 |
| Efficacy of HIPEC in the Treatment of Advanced-Stage Epithelial Ovarian Cancer After Cytoreductive Surgery Hyperthermic Intraperitoneal Chemotherapy, cytoreductive surgery, adjuvant chemotherapy - Epithelial Ovarian Cancer, Fallopian Tube Cancer | Phase 3 | Unknown | Affiliated Cancer Hospital & Institute of Guangzhou Medical University | 310 | 2019-10-15 | 2019-11-06 |
| Hyperthermic Intraperitoneal Chemotherapy Trial Comparing Quality of Life in Patients With Stage IIIC-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Carboplatin, Quality-of-Life Assessment, Questionnaire Administration - Stage IIIC Fallopian Tube Cancer, Stage IIIC Ovarian Cancer | Phase 2 | Completed | Wake Forest University Health Sciences | 50 | 2019-01-02 | 2026-08-21 |
| Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma Cisplatin, Sodium thiosulfate, Cytoreductive surgery - Adrenocortical Carcinoma, Peritoneal Carcinomatosis | Phase 2 | Active not recruiting | Columbia University | 30 | 2017-09-22 | 2026-05-06 |
| A Study of Carboplatin and Paclitaxel Chemotherapy With Nivolumab With or Without Ipilimumab in Patients With Ovarian Cancer Carboplatin and Paclitaxel, Nivolumab, Cytoreductive surgery - High Grade Serous Ovarian, Fallopian Tube | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 27 | 2017-08-04 | 2025-12-17 |
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Ovarian Neoplasms (16) · Peritoneal Neoplasms (10) · Fallopian Tube Neoplasms (7) · Colorectal Neoplasms (6) · Adrenocortical Carcinoma (3) · Carcinoma, Ovarian Epithelial (3) · Colonic Neoplasms (3) · Stomach Neoplasms (3) · Appendiceal Neoplasms (2) · Brain Neoplasms (2) · Carcinoma (2) · Desmoplastic Small Round Cell Tumor (2) · Gastrointestinal Neoplasms (2) · Glioblastoma (2) · Glioma (2)
National Cancer Institute (NCI) (5) · Memorial Sloan Kettering Cancer Center (3) · Andrew B Lassman, MD (2) · M.D. Anderson Cancer Center (2) · Masonic Cancer Center, University of Minnesota (2) · The University of Hong Kong (2) · University Hospital, Ghent (2) · Affiliated Cancer Hospital & Institute of Guangzhou Medical University (1) · Clinica Universidad de Navarra, Universidad de Navarra (1) · Columbia University (1) · Eastern Hepatobiliary Surgery Hospital (1) · European Society of Gynaecological Oncology (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · Jianxing He (1) · Kalinski, Pawel, MD, PhD (1)
United States (21) · China (5) · Belgium (3) · Germany (2) · Hong Kong (2) · Italy (2) · Spain (2) · South Korea (1)
Aaron S Mansfield (1) · Aaron Shafer, MD (1) · Andrea Hayes-Jordan, MD (1) · Andrew B. Lassman, MD (1) · Andrew Lassman, MD (1) · Anna Solini, MD, PhD (1) · Carol Aghajanian, MD (1) · David S Schrump, M.D. (1) · Dennis Chi, MD (1) · Floor Backes, MD (1) · Garrett Nash, MD, MPH (1) · Guoxin Li (1) · Hee Seung Kim, MD/PhD (1) · Jeremy L Davis, M.D. (1)
PMID 11762804, PMID 14745444, PMID 16452199, PMID 16790085, PMID 19942597, PMID 20008305, PMID 24756812, PMID 26673788, PMID 26903580, PMID 27633880, PMID 27650694, PMID 30131226, PMID 30463745, PMID 31262599, PMID 37673112, PMID 37690994, PMID 37945326, PMID 38479803, PMID 41175449, PMID 41352872
2009 (1), 2025 (1), P30CA012197 (1), U10CA180821 (1)