48 completed, 6 terminated, 6 unknown, 5 withdrawn. 25 Phase 2, 16 Phase 3, 16 Phase 4, 5 Not applicable, 4 Phase 1.
Follow Cyclosporine A: new trials by email Literature Review of Cyclosporine A trials Research Report on Cyclosporine A
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A Cyclosporine A, Placebo Comparator: Placebo - Fungal Keratitis, Corneal Ulcer | Phase 3 | Recruiting | University of California, San Francisco | 150 | 2025-09-01 | 2026-06-05 |
| Cyclosporine In Takotsubo Syndrome Cyclosporine A, Placebo - Takotsubo Cardiomyopathy | Phase 2 | Recruiting | University Hospital Heidelberg | 204 | 2025-02-01 | 2026-05-01 |
| Efficacy of Romiplostim in Treatment of SAA in Adults Previously Untreated With or Refractory to Immunosuppressive Therapy Romiplostim, Antithymocyte Globulin, Cyclosporine A - Severe Aplastic Anemia (SAA) | Phase 2 | Withdrawn | Amgen | 2023-08-31 | 2023-09-29 | |
| Clinical Study of UCB Combined With UC-MSCs in the Treatment of Bone Marrow Failure Disorders Cyclosporine A, Umbilical cord blood & Umbilical cord derived mesenchymal stem cells - Bone Marrow Failure Disorders | Phase 1 / Phase 2 | Unknown | Shandong Qilu Stem Cells Engineering Co., Ltd. | 100 | 2023-08-01 | 2023-11-29 |
| Herombopag Added to Cyclosporine in Non Severe Aplastic Anemia Herombopag - Non Severe Aplastic Anemia, Untreated | Phase 2 | Completed | Institute of Hematology & Blood Diseases Hospital, China | 54 | 2022-12-01 | 2025-08-05 |
| a Retrospective Study on the Systemic Treatment of LPP and FFA Hydroxychloroquine, Methotrexate, Cyclosporine A - Cicatricial Alopecia, Lichen Planopilaris | Completed | Erasmus Medical Center | 315 | 2022-09-23 | 2024-07-22 | |
| A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications Belatacept, Tacrolimus, Cyclosporine A - Renal Allograft Recipients | Phase 3 | Recruiting | Bristol-Myers Squibb | 102 | 2021-07-21 | 2026-08-31 |
| Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCA Sirolimus, Cyclosporine A - Pure Red Cell Aplasia, Acquired | Phase 4 | Completed | Bing Han | 56 | 2020-07-01 | 2023-02-28 |
| Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study Busulfan, Cyclophosphamide, Fludarabine - Thalassemia Major | Phase 4 | Completed | First Affiliated Hospital of Guangxi Medical University | 823 | 2019-07-05 | 2024-08-09 |
| Investigation of Flare and Remission in Subjects With Atopic Dermatitis Cyclosporine A - Atopic Dermatitis | Phase 4 | Withdrawn | LEO Pharma | 2019-01-14 | 2024-11-07 | |
| Chidamide Plus PTCy/Cyclosporine to Prevent GVHD After Myeloablative Conditioning, Matched PBSCT Chidamide, Cyclophosphamide, cyclosporine A - Leukemia, Acute, MDS | Phase 2 | Unknown | Sichuan University | 50 | 2019-01-01 | 2018-07-18 |
| Multicenter Registry of Pediatric Lupus Nephritis in China Corticosteroid, Hydroxychloroquine, Cyclophosphamide - Lupus Nephritis, Children | Unknown | Xiqiang Dang | 1200 | 2018-12-01 | 2019-04-05 | |
| Cyclosporine A Pretreatment and Kidney Graft Function cyclosporine A, Placebo - Brain Death, Kidney Transplantation | Phase 4 | Completed | University Hospital, Clermont-Ferrand | 648 | 2017-12-19 | 2026-08-03 |
| Traumatic Brain Injury and Effects of Acute Cyclosporine A Cyclosporine A, Placebo - Traumatic Brain Injury | Phase 1 / Phase 2 | Withdrawn | Edward Hall,PhD | 2017-08-07 | 2017-10-26 | |
| Drug/Drug Interactions With F901318 cyclosporine A, Posaconazole, Pantoprazole - Invasive Aspergillosis | Phase 1 | Withdrawn | F2G Ltd | 2017-05-01 | 2017-11-01 | |
| Postconditioning by Cyclosporin A in Pulmonary Transplantation Cyclosporine A, Placebo - Lung Transplantation | Phase 3 | Withdrawn | Hospices Civils de Lyon | 2017-01-01 | 2019-03-14 | |
| Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases Fludarabine, Cyclophosphamide, Total Body Irradiation - Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL) | Not applicable | Terminated | Masonic Cancer Center, University of Minnesota | 200 | 2016-12-01 | 2026-05-20 |
| CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED) Cyclosporine A, Placebo - Dry Eye Syndromes | Phase 2 | Completed | Novaliq GmbH | 207 | 2016-01-01 | 2019-11-06 |
| The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia Thymoglobulin, Cord blood, Cyclosporine Oral Product - Severe Aplastic Anemia | Phase 4 | Completed | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 60 | 2016-01-01 | 2023-03-17 |
| A Multi-Institutional Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Malignant Neuro-Epithelial and Other Solid Tumors Allogeneic hematopoietic stem cell transplant following thiotepa-based marrow ablative chemotherapy, Keratinocyte Growth Factor, Alemtuzumab - Neuroepithelial Tumor, Solid Tumor | Early Phase 1 | Terminated | Montefiore Medical Center | 1 | 2015-09-01 | 2017-08-17 |
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Anemia, Aplastic (5) · Adrenoleukodystrophy (3) · Bone Marrow Failure Disorders (3) · Dermatitis, Atopic (3) · Graft vs Host Disease (3) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (3) · Leukemia, Myeloid, Acute (3) · Leukodystrophy, Globoid Cell (3) · Leukodystrophy, Metachromatic (3) · Myelodysplastic Syndromes (3) · Dry Eye Syndromes (2) · Gangliosidosis, GM1 (2) · Insulin Resistance (2) · Kidney Failure, Chronic (2) · Lupus Nephritis (2)
Masonic Cancer Center, University of Minnesota (5) · Novartis Pharmaceuticals (5) · University of Oslo School of Pharmacy (4) · Hospices Civils de Lyon (3) · Bristol-Myers Squibb (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Amgen (1) · Assistance Publique - Hôpitaux de Paris (1) · Bing Han (1) · Boston Children's Hospital (1) · Charite University, Berlin, Germany (1) · Edward Hall,PhD (1) · Erasmus Medical Center (1) · F2G Ltd (1) · First Affiliated Hospital of Guangxi Medical University (1)
United States (22) · France (9) · Germany (9) · China (8) · Norway (7) · Switzerland (6) · Spain (5) · Austria (4) · Italy (4) · Australia (3) · Belgium (3) · Netherlands (3) · Argentina (2) · Canada (2) · Czechia (2)
Paul Orchard, MD (2) · Alberto Sanchez-Fueyo, MD (1) · Alexander Navarini, Prof Dr med (1) · Allan Glanville, MD, PhD (1) · Arnt Fiane, MD, Ph.D. (1) · Bastian Bruns, MD (1) · Bing Han, PhD (1) · Christoph Tappeiner, MD (1) · Chun Wang, M.D., Ph. D. (1)
PMID 12270445, PMID 15691277, PMID 15919463, PMID 16771810, PMID 19208097, PMID 19926370, PMID 20605876, PMID 21051752, PMID 21401729, PMID 21586746, PMID 22143911, PMID 23369437, PMID 23866828, PMID 24363761, PMID 24530759, PMID 25050491, PMID 25354103, PMID 26504182, PMID 26821623, PMID 27433815, PMID 27470087, PMID 27881371, PMID 27999018, PMID 28605781, PMID 29665840, PMID 29982851, PMID 30231851, PMID 30703441, PMID 32030447, PMID 34086408, PMID 34116828, PMID 34724566, PMID 37160872, PMID 40268179, PMID 41489450, PMID 41504889, PMID 41730859
2009 (1), 2014 (1), 2018 (1), U01HL069294 (1), U24CA076518 (1)