14 completed, 2 withdrawn, 1 terminated, 1 unknown. 7 Phase 4, 6 Phase 3, 3 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 7 | Completed 4, Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 3 | 6 | Completed 5, Withdrawn 1 |
| Not applicable | 3 | Completed 3 |
| Phase 2 | 2 | Completed 2 |
Follow Crinone: new trials by email Literature Review of Crinone trials Research Report on Crinone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer. Progesterone-IBSA Injectable Solution, Progesterone Vaginal Gel with Applicator, Placebo Vaginal gel with applicator - Infertility | Phase 3 | Completed | IBSA Institut Biochimique SA | 688 | 2022-10-12 | 2026-08-27 |
| Luteal Support in Frozen-Thawed Embryo Transfer Cycles Dydrogesterone 10Mg Tablet (duphaston), Progesterone 50Mg/mL Oil, Crinone 8% Vaginal Gel - Implantation; Placenta, Pregnancy Loss | Phase 4 | Completed | Centrum Clinic IVF Center | 151 | 2021-06-30 | 2022-01-11 |
| Efficacy and Safety of Crinone Versus Combination Medication (ACCESS) Crinone, Duphaston - Infertility | Phase 4 | Terminated | Merck KGaA, Darmstadt, Germany | 172 | 2019-05-31 | 2024-03-12 |
| Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles Dydrogesterone 10 MG Oral Tablet, Progesterone Vaginal Gel [Crinone] - Infertility, Female, Infertility, Male | Phase 4 | Unknown | Memorial Sisli Hospital, Istanbul | 140 | 2019-01-02 | 2019-10-14 |
| Hormones and Reduction in Co-users of Marijuana and Nicotine Progesterone, placebo - Marijuana Dependence | Not applicable | Completed | University of Minnesota | 58 | 2015-11-01 | 2020-06-26 |
| A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II) Dydrogesterone 30 mg, intravaginal progesterone gel 90 mg - Female Infertility | Phase 3 | Completed | Abbott | 1034 | 2015-07-01 | 2019-10-01 |
| An Efficacy and Safety Study of Corifollitropin Alfa (MK-8962) in Contrast to Recombinant FSH for Use in Controlled Ovarian Stimulation of Indian Women (P07056, Also Known as MK-8962-029) MK-8962, recFSH, Ganirelix - Infertility | Phase 3 | Withdrawn | Organon and Co | 2014-03-01 | 2022-02-03 | |
| Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole Progesterone Vaginal Gel 8%, Letrozole Oral Tablet, pelvic ultrasound - Polycystic Ovary Syndrome | Phase 2 / Phase 3 | Completed | Eastern Virginia Medical School | 52 | 2012-07-06 | 2018-02-26 |
| Intrauterine Insemination and Luteal Fase Support crinone (progesterone 8%, vaginal application) - Infertility | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 393 | 2011-04-01 | 2018-10-19 |
| Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF) Menotrophin, Follitrophin alpha, Cetrorelix - Infertility | Phase 4 | Completed | Ferring Pharmaceuticals | 124 | 2010-10-01 | 2014-03-14 |
| Dydrogesterone Versus Intravaginal Progesterone in the Luteal Phase Support Oral dydrogesterone, Crinone 8% gel - Luteal Phase Defect | Not applicable | Completed | University of Zagreb | 853 | 2010-10-01 | 2014-01-29 |
| Ovarian Response Prediction in In Vitro Fertilization (IVF) Patients Ovarian stimulation in a GnRH-antagonist protocol - Infertility, Subfertility | Completed | University Hospital Schleswig-Holstein | 294 | 2010-09-01 | 2016-01-05 | |
| Low Molecular Weight Heparin in Recurrent Implantation Failure low molecular weight heparin (enoxaparine sodium), crinone 8% gel - Infertility, Fertilization in Vitro | Not applicable | Completed | V.K.V. American Hospital, Istanbul | 2006-01-01 | 2009-03-20 | |
| Multi-Center, Randomized, Open-Label, Parallel Group Study of a Vaginal Micronized Progesterone Tablet (Endometrin®) Compared to Crinone 8% Vaginal Gel in Female Patients Undergoing In-Vitro Fertilization (IVF) Endometrin, Crinone - Fertility | Phase 3 | Completed | Ferring Pharmaceuticals | 1211 | 2005-07-01 | 2011-05-19 |
| Comparison of DR-2011 to a Progesterone Vaginal Gel for Luteal Phase Replacement DR-2011, Progesterone 8% Vaginal Gel - Infertility | Phase 2 | Completed | Duramed Research | 20 | 2005-06-01 | 2014-05-12 |
| Vaginal Progesterone to Reduce the Risk of Another Preterm Birth 8% progesterone vaginal gel, Placebo Vaginal Gel - Pregnancy | Phase 3 | Completed | Juniper Pharmaceuticals, Inc. | 636 | 2004-04-01 | 2010-08-19 |
| Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF) Crinone 8% Vaginal Gel, Intramuscular Progesterone - Infertility | Phase 4 | Completed | Brigham and Women's Hospital | 468 | 2003-07-01 | 2011-09-22 |
| Comparison of Vaginal and Intramuscular Progesterone in Vitrified-warmed Blastocyst Transfer Cycles Vaginal progesterone gel (Crinone® 8%), Intramuscular Progesterone - Infertility | Phase 4 | Withdrawn | Brigham and Women's Hospital | 2019-09-09 |
Infertility (10) · Infertility, Female (2) · Helping Behavior (1) · Infertility, Male (1) · Marijuana Abuse (1) · Polycystic Ovary Syndrome (1)
Brigham and Women's Hospital (2) · Ferring Pharmaceuticals (2) · Abbott (1) · Centrum Clinic IVF Center (1) · Duramed Research (1) · Eastern Virginia Medical School (1) · IBSA Institut Biochimique SA (1) · Juniper Pharmaceuticals, Inc. (1) · Memorial Sisli Hospital, Istanbul (1) · Merck KGaA, Darmstadt, Germany (1) · Organon and Co (1) · Universitaire Ziekenhuizen KU Leuven (1) · University Hospital Schleswig-Holstein (1) · University of Minnesota (1) · University of Zagreb (1)
United States (7) · Germany (3) · Turkey (Türkiye) (3) · Belgium (2) · China (2) · Australia (1) · Croatia (1) · Hong Kong (1) · India (1) · Norway (1) · Russia (1) · Singapore (1) · Thailand (1) · Ukraine (1)
Cumhur B Urman, M.D. (1) · Elena H Yanushpolsky, M.D. (1) · Elena Yanushpolsky, MD (1) · Emre Pabuccu, Assoc. Prof. (1) · George W Creasy, MD (1) · Jozo Tomic, M.D. (1) · Laurel A Stadtmauer, MD, PhD (1) · Semra Kahraman, Prof (1) · Sharon Allen, Ph.D,M.D. (1) · Shreyansh Shah, MD (1) · Vlatka Tomic, M.D. (1)
PMID 30304457, PMID 17899571, PMID 17899572, PMID 19357135, PMID 19918965, PMID 20347079, PMID 25622239, PMID 27565253, PMID 27761732, PMID 29338855