49 completed, 6 terminated, 4 unknown, 2 active not recruiting. 30 Phase 4, 12 Phase 3, 8 Not applicable, 8 Phase 2, 2 Phase 1.
Follow Artemether-lumefantrine: new trials by email Literature Review of Artemether-lumefantrine trials Research Report on Artemether-lumefantrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety of Antimalarials in the FIRst trimEster dihydroartemisinin-piperaquine (DP), Pyronaridine-artesunate (PA), Artemether-lumefantrine - Malaria, Pregnancy, Malaria, Antepartum | Phase 3 | Recruiting | Liverpool School of Tropical Medicine | 1510 | 2025-09-30 | 2025-11-19 |
| The Impact RTS,S/AS01 Vaccine in School Aged Children RTS,S/AS01 Malaria Vaccine in School Aged Children Mosquirixs, artemether-lumefantrine - Malaria,Falciparum | Phase 4 | Unknown | Kamuzu University of Health Sciences | 5400 | 2024-06-01 | 2024-05-21 |
| The Transmission of Artemisinin Resistant Parasites Before and After Conventional Artemisinin-combination Therapy Artemether-lumefantrine, Dihydroartemisinin-Piperaquine - Falciparum; Malaria | Phase 4 | Completed | Infectious Diseases Research Collaboration, Uganda | 160 | 2024-05-28 | 2026-07-06 |
| Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo Artesunate-amodiaquine, Artemether-lumefantrine - Uncomplicated Plasmodium Falciparum Malaria | Phase 4 | Completed | Ministry of Public Health, Democratic Republic of the Congo | 1260 | 2023-05-01 | 2024-11-05 |
| Triple Artemisinin-based Combination Therapy for Delaying Drug Resistance Development - a Randomized Clinical Trial Artemether-lumefantrine and Amodiaquine Drug Combination, Artemether-lumefantrine then Artesunate amodiaquine, Artemether-lumefantrine - Uncomplicated Plasmodium Falciparum Malaria | Phase 2 / Phase 3 | Completed | Muhimbili University of Health and Allied Sciences | 384 | 2023-05-01 | 2026-09-23 |
| Pharmacokinetics of Antimalarials in Breastfeeding Ugandan Mother-infant Pairs Artemether-lumefantrine - Malaria,Falciparum | Active not recruiting | University of Liverpool | 30 | 2023-03-20 | 2026-05-06 | |
| Pharmacokinetic Study of Artemether-lumefantrine and Amodiaquine in Healthy Subjects Artemether-lumefantrine, Amodiaquine, Artemether-lumefantrine + Amodiaquine - Pharmacokinetic, Healthy | Phase 1 | Terminated | University of Oxford | 8 | 2022-11-01 | 2026-01-12 |
| Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali Artesunate-amodiaquine combination, Primaquine Phosphate, Artemether-lumefantrine - Malaria,Falciparum | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 100 | 2022-10-17 | 2024-10-01 |
| Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali Artemether-lumefantrine, Primaquine Phosphate, Sulphadoxine-pyrimethamine with amodiaquine - Malaria,Falciparum | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 80 | 2021-10-12 | 2022-01-18 |
| Safety and Efficacy of Maytenus Senegalensis for the Treatment of Uncomplicated Malaria Maytenus Senegalensis - Malaria | Phase 2 | Completed | Ifakara Health Institute | 12 | 2021-06-02 | 2023-07-18 |
| Evaluation of Three Artemisinin-based Combinations for the Treatment of Uncomplicated Malaria in Childreen in Burkina Faso (CHIMIO2) Artemether-lumefantrine - Malaria, Burkina Faso | Phase 4 | Unknown | Centre national de recherche et de formation sur le paludisme | 1050 | 2021-06-01 | 2021-03-03 |
| Optimizing Malaria Treatment for HIV-Malaria Co-infected Individuals Artemether-lumefantrine - HIV Coinfection, Malaria | Phase 4 | Unknown | Makerere University | 888 | 2021-01-18 | 2023-01-06 |
| Safety and Efficacy of Recommended Antimalarial in the Democratic Republic of the Congo Artesunate-amodiaquine, Artemether-lumefantrine - Malaria | Phase 4 | Completed | Ministry of Public Health, Democratic Republic of the Congo | 1117 | 2020-10-26 | 2022-02-09 |
| Efficacy of Antimalarial Drugs Used for the Treatment of Uncomplicated Malaria, Plasmodium Falciparum, at the Agadez, Gaya and Tessaoua Sentinel Sites Artemether-lumefantrine - MALARIA | Phase 4 | Completed | Programme National de Lutte contre le Paludisme, Niger | 259 | 2020-09-01 | 2021-10-07 |
| Study to Assess Efficacy of Artemether-lumefantrine Prophylaxis Against Forest Malaria in Cambodia (PAL_Cambodia) Artemether-lumefantrine, Multivitamin - Malaria | Not applicable | Completed | University of Oxford | 1480 | 2020-03-11 | 2024-03-20 |
| Pharmacokinetics and Pharmacodynamics of the Gametocytocidal and Post-treatment Chemoprotective Effects of Antimalarials Artemether-lumefantrine, Dihydroartemisinin-piperaquine - Uncomplicated Falciparum Malaria | Phase 2 / Phase 3 | Active not recruiting | Johns Hopkins Bloomberg School of Public Health | 182 | 2019-06-19 | 2025-12-17 |
| Effect of Atazanavir-ritonavir on the Pharmacokinetics and Toxicity of Lumefantrine Artemether-lumefantrine, Atazanavir-ritonavir 300/100 mg - Drug Interaction | Phase 4 | Completed | Fogarty International Center of the National Institute of Health | 20 | 2018-09-18 | 2020-08-28 |
| Effect of Artemisinin-based Combination Therapies on Schistosomiasis on Malaria Co-infection Artesunate-Pyronaridine, Artemether-Lumefantrine, Artefenomel-Ferroquine - Schistosomiasis Haematobia | Phase 2 | Completed | Centre de Recherche Médicale de Lambaréné | 54 | 2018-07-31 | 2020-02-11 |
| Comparison of Arterolane-piperaquine Versus Arterolane-piperaquine+Mefloquine Versus Artemether-lumefantrine in Kenyan Children Arterolane-piperaquine, Arterolane-piperaquine+mefloquine, Artemether-lumefantrine - Plasmodium Falciparum | Phase 3 | Completed | University of Oxford | 219 | 2018-03-07 | 2021-09-29 |
| Extended Duration Artemether-lumefantrine Treatment for Malaria in Children Artemether-lumefantrine - Uncomplicated Plasmodium Falciparum Malaria | Phase 4 | Completed | University of California, San Francisco | 305 | 2018-02-21 | 2025-04-15 |
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Malaria (36) · Malaria, Falciparum (28) · HIV Infections (2) · Disease (1) · Fever (1) · Malaria, Vivax (1) · Schistosomiasis haematobia (1) · Trigeminal Neuralgia (1)
Centers for Disease Control and Prevention (6) · London School of Hygiene and Tropical Medicine (4) · Novartis (4) · University of Oxford (4) · Centre Muraz (3) · Ministry of Public Health, Democratic Republic of the Congo (3) · University of California, San Francisco (3) · Karolinska University Hospital (2) · Makerere University (2) · National Institute for Medical Research, Tanzania (2) · Novartis Pharmaceuticals (2) · Professor Anders Björkman (2) · Research Institute for Tropical Medicine, Philippines (2) · Albert Schweitzer Hospital (1) · Bandim Health Project (1)
Tanzania (14) · Burkina Faso (10) · Kenya (7) · Mali (6) · Uganda (6) · Ghana (4) · Benin (3) · Democratic Republic of the Congo (3) · Nigeria (3) · Brazil (2) · Gabon (2) · Mozambique (2) · Niger (2) · Thailand (2) · Zambia (2)
Alassane Dicko (2) · Gauthier Mesia Kahunu, PhD (2) · Abdullah Ali (1) · Adam Bennett, MA, PhD (1) · Adama Gansane, PhD (1) · Ambrose O Talisuna, PhD (1) · Anders Bjorkman, Professor (1) · Andreas Martensson (1) · Andreas Martensson, PhD (1) · Billy E Ngasala, PhD (1)
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R01HD068174 (1)