9 completed, 4 unknown. 13 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 9, Unknown 4 |
| Phase 1 | 1 | Completed 1 |
Follow afamelanotide: new trials by email Literature Review of afamelanotide trials Research Report on afamelanotide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics of Afamelanotide in Erythropoietic Protoporphyria Patients Afamelanotide 16mg implant - Erythropoietic Protoporphyria | Phase 1 / Phase 2 | Completed | Clinuvel Europe Limited | 28 | 2024-03-07 | 2026-07-27 |
| Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Variegate Porphyria (VP) Afamelanotide 16 MG - Variegate Porphyria | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 6 | 2023-03-28 | 2025-04-27 |
| A Study to Assess the Changes in Pigmentation and Safety of Afamelanotide in Patients With Vitiligo on the Face Afamelanotide - Vitiligo | Phase 2 | Unknown | Clinuvel, Inc. | 6 | 2022-10-11 | 2023-02-09 |
| A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V Afamelanotide - Xeroderma Pigmentosum | Phase 2 | Unknown | Clinuvel Europe Limited | 6 | 2022-03-28 | 2023-09-21 |
| A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum (XP) Afamelanotide - Xeroderma Pigmentosum | Phase 2 | Unknown | Clinuvel Europe Limited | 6 | 2021-10-19 | 2023-06-18 |
| A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS) Afamelanotide - Arterial Ischemic Stroke | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 6 | 2021-06-03 | 2023-04-11 |
| Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Phototherapy in the Treatment of Nonsegmental Vitiligo (NSV) Afamelanotide, Placebo - Vitiligo | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 21 | 2014-06-06 | 2023-09-22 |
| Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo Afamelanotide, NB-UVB - Vitiligo | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 15 | 2011-09-01 | 2013-03-22 |
| Afamelanotide in Patients Suffering With Acne Vulgaris Afamelanotide - Acne Vulgaris | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 3 | 2010-08-24 | 2021-10-26 |
| Phase II Confirmatory Study in Erythropoietic Protoporphyria (EPP) Afamelanotide, Placebo - Erythropoietic Protoporphyria | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 77 | 2010-04-01 | 2019-10-28 |
| Phase II Solar Urticaria (SU) Pilot Study afamelanotide - Solar Urticaria | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 5 | 2008-12-01 | 2009-09-15 |
| Afamelanotide as Adjunctive Therapy in Patients Undergoing Photodynamic Therapy (PDT) Utilising Porfimer Sodium Afamelanotide, Placebo - Patients Undergoing Photodynamic Therapy Using Porfimer Sodium | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 16 | 2008-08-05 | 2021-10-01 |
| Phase II AK Study in Organ Transplant Patients Afamelanotide (CUV1647), Placebo - Actinic Keratoses, Carcinoma, Squamous Cell | Phase 2 | Unknown | Clinuvel Pharmaceuticals Limited | 200 | 2007-11-01 | 2010-12-06 |
Vitiligo (3) · Protoporphyria, Erythropoietic (2) · Xeroderma Pigmentosum (2) · Acne Vulgaris (1) · Carcinoma, Squamous Cell (1) · Ischemic Stroke (1) · Keratosis, Actinic (1) · Porphyria, Variegate (1) · Urticaria, Solar (1)
Clinuvel Pharmaceuticals Limited (9) · Clinuvel Europe Limited (3) · Clinuvel, Inc. (1)
Belgium (3) · Australia (2) · Germany (2) · Netherlands (2) · United States (2) · France (1) · Italy (1) · Spain (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Giovanni Leone, MD (1) · Lesley Rhodes, M.D. (1) · Robert Desnick, MD (1)