6 completed, 3 terminated, 1 active not recruiting, 1 not yet recruiting. 13 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Completed 6, Terminated 3, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 2 | 4 | Not yet recruiting 1, Recruiting 1, Terminated 1, Withdrawn 1 |
Follow ADI-PEG 20: new trials by email Literature Review of ADI-PEG 20 trials Research Report on ADI-PEG 20
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) ADI-PEG 20 (Arginine deiminase pegylated), Temozolomide (TMZ), Standard of Care Radiation Therapy (RT) - Glioblastoma, High-Grade Glioma (WHO III-IV) | Phase 1 / Phase 2 | Not yet recruiting | Sabine Mueller, MD, PhD | 97 | 2027-06-01 | 2026-11-09 |
| Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC) ADI-PEG 20, Cabazitaxel, Carboplatin - Prostate Cancer | Phase 1 / Phase 2 | Recruiting | M.D. Anderson Cancer Center | 30 | 2024-02-29 | 2026-09-18 |
| A Study Evaluating Atezolizumab and Bevacizumab Plus ADI-PEG 20 in Patients With Locally Advanced / Metastatic Hepatocellular Carcinoma Atezolizumab, Bevacizumab, ADI-PEG 20 - Metastatic Hepatocellular Carcinoma | Phase 1 / Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2023-08-08 | 2024-08-26 | |
| ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers ADI-PEG 20, Gemcitabine, Docetaxel - Non Small Cell Lung Cancer, Non-small Cell Lung Cancer | Phase 1 / Phase 2 | Terminated | Washington University School of Medicine | 31 | 2023-04-05 | 2026-07-27 |
| Study of ADI-PEG 20, Venetoclax and Azacitidine in Acute Myeloid Leukemia ADI-PEG 20 - Acute Myeloid Leukemia, Adult | Phase 1 | Active not recruiting | Polaris Group | 38 | 2022-04-05 | 2026-10-15 |
| Ph 1 Study of ADI-PEG 20 Plus Low Dose Cytarabine in Older Patients With AML ADI-PEG 20, Cytarabine - Acute Myeloid Leukemia | Phase 1 | Terminated | Polaris Group | 23 | 2017-01-20 | 2020-03-05 |
| Ph 1B Trial With ADI-PEG 20 Plus Nab-Paclitaxel and Gemcitabine in Subjects With Pancreatic Cancer ADI-PEG 20 - Advanced Pancreatic Cancer | Phase 1 | Completed | Polaris Group | 21 | 2014-11-17 | 2020-10-01 |
| Ph 1 Trial of ADI PEG 20 Plus Sorafenib to Treat Patients With Liver Cancer ADI-PEG 20 - Hepatocellular Carcinoma | Phase 1 | Completed | Polaris Group | 8 | 2014-11-01 | 2016-03-04 |
| Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin ADI-PEG 20 - Pleural Mesothelioma Malignant Advanced, Peritoneal Mesothelioma Malignant Advanced | Phase 1 | Terminated | Polaris Group | 85 | 2014-04-23 | 2020-09-25 |
| Ph 1 ADI-PEG 20 Plus Doxorubicin; Patients With HER2 Negative Metastatic Breast Cancer ADI-PEG 20 - HER2 Negative Metastatic Breast Cancer | Phase 1 | Completed | Polaris Group | 15 | 2014-04-01 | 2016-04-14 |
| Ph 1 Trial of ADI-PEG 20 Plus Cisplatin in Patients With Metastatic Melanoma ADI-PEG 20 - Cutaneous Melanoma, Uveal Melanoma, Ovarian Carcinoma or Other Advanced Solid Tumors | Phase 1 | Completed | Polaris Group | 8 | 2012-09-01 | 2016-02-25 |
| Ph 1 Study of ADI PEG 20 in Pediatric Subjects Who Are Argininosuccinate Synthetase (ASS) Deficient ADI-PEG 20 - Argininosuccinate Synthetase Deficient | Phase 1 | Completed | Polaris Group | 8 | 2011-12-01 | 2014-04-09 |
| Ph 1 Trial of ADI-PEG 20 Plus Docetaxel in Solid Tumors With Emphasis on Prostate Cancer and Non-Small Cell Lung Cancer ADI-PEG 20 - Solid Tumors, Prostate Cancer | Phase 1 | Completed | Polaris Group | 43 | 2011-09-06 | 2018-09-13 |
Carcinoma, Hepatocellular (3) · Glioma (2) · Leukemia, Myeloid, Acute (2) · Prostatic Neoplasms (2) · Uveal Melanoma (2) · Carcinoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Glioblastoma (1) · Melanoma (1) · Ovarian Neoplasms (1) · Small Cell Lung Carcinoma (1)
Polaris Group (9) · M.D. Anderson Cancer Center (2) · Sabine Mueller, MD, PhD (1) · Washington University School of Medicine (1)
United States (12) · Taiwan (2) · United Kingdom (1)
Siqing Fu, MD (2) · Ana Aparicio, MD (1) · Christine Auberle, M.D. (1) · Cynthia Herzog, MD (1) · Ghassan Abou-Alfa, MD (1) · John S Bomalaski, MD (1) · Maeve Lowery, MD (1) · Peter Szlosarek, MD, PhD (1) · Sabine Mueller, MD, PhD (1) · Tom Davidson, MD (1)