12 completed. 12 Phase 1.
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All 12 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|
A Study to Investigate the Effects of Daridorexant on Nighttime Breathing in Patients With Shallow or Paused Breath During Sleep
Daridorexant, Placebo - Obstructive Sleep Apnea of Adult | Phase 1 | Completed | 20 | 2022-08-17 | 2023-04-04 |
Study of the Way the Body Takes up, Distributes, and Gets Rid of ACT-541468 in Subjects With Abnormal Kidney Function Compared to Healthy Subjects
ACT-541468 - Renal Insufficiency, Healthy | Phase 1 | Completed | 16 | 2019-09-24 | 2020-09-03 |
A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects
ACT-541468, Zopiclone 7.5 mg, Placebo - Healthy | Phase 1 | Completed | 56 | 2019-03-25 | 2019-10-31 |
A Study to Investigate the Effects of ACT-541468 on Nighttime Respiratory Function in Patients With Mild to Moderate Obstructive Sleep Apnea
ACT-541468, Placebo - Obstructive Sleep Apnea | Phase 1 | Completed | 28 | 2019-03-14 | 2019-12-19 |
A Clinical Study to Investigate the Food Effect on the Pharmacokinetics of ACT-541468 in Healthy Male Subjects
ACT-541468 - Healthy | Phase 1 | Completed | 20 | 2019-03-09 | 2019-04-12 |
A Study to Evaluate the Effects of ACT-541468 on Respiration in Patients With Moderate Chronic Obstructive Pulmonary Disease
ACT-541468, Placebo - Chronic Obstructive Pulmonary Disease | Phase 1 | Completed | 28 | 2018-11-15 | 2019-09-23 |
Study to Evaluate the Abuse Potential of ACT-541468 in Healthy Recreational Drug Users
ACT-541468, Suvorexant, Zolpidem - Healthy Recreational Drug Users | Phase 1 | Completed | 63 | 2018-09-07 | 2019-09-19 |
A Study to Investigate the Drug-drug Interactions Between ACT-541468 and Ethanol in Healthy Subjects
ACT-541468, ACT-541468 placebo, Ethanol 10% - Healthy | Phase 1 | Completed | 22 | 2018-08-28 | 2018-10-15 |
A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-541468 Can Affect the Fate in the Body (Amount and Time of Presence in the Blood) of Rosuvastatin
Rosuvastatin, ACT-541468 - Healthy Subjects | Phase 1 | Completed | 20 | 2017-10-30 | 2017-12-11 |
A Study of ACT-541468 in Healthy Japanese and Caucasian Subjects
ACT-541468, placebo - Healthy Subjects | Phase 1 | Completed | 40 | 2017-03-15 | 2018-07-10 |
A Clinical Study to Investigate the Potential Interactions Between Food and ACT-541468 and Between ACT-541468 and Midazolam
Midazolam, ACT-541468 - Healthy Subjects | Phase 1 | Completed | 20 | 2017-01-01 | 2018-07-10 |
Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects
ACT-541468, Diltiazem - Healthy Subjects | Phase 1 | Completed | 14 | 2015-09-01 | 2018-07-10 |
Conditions studied
Pulmonary Disease, Chronic Obstructive (1) · Renal Insufficiency (1) · Sleep Apnea, Obstructive (1)
Sponsors
Idorsia Pharmaceuticals Ltd. (12)
Countries
Germany (6) · Netherlands (3) · Czechia (2) · Canada (1) · United States (1)
Top investigators
Marie-Laure Boof, PhD (2) · Clemens Muehlan (1) · Pascale Gasser (1)
Results publications
PMID 33205362, PMID 33305817, PMID 34480579, PMID 35306405, PMID 42171662
NIH funding
2018 (2), 2016 (1), 2019 (1)