18 completed, 1 not yet recruiting, 1 recruiting, 1 unknown. 7 Phase 4, 5 Phase 3, 4 Phase 1, 4 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 7 | Completed 6, Not yet recruiting 1 |
| Phase 3 | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 4 | Completed 4 |
| Early Phase 1 | 1 | Completed 1 |
Follow 23-valent pneumococcal polysaccharide vaccine: new trials by email Literature Review of 23-valent pneumococcal polysaccharide vaccine trials Research Report on 23-valent pneumococcal polysaccharide vaccine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preoperative Pneumococcal and Influenza Vaccination to Prevent Postoperative Pulmonary Infection in Patients Undergoing Lung Resection for Pulmonary Nodules or Lung Cancer 23-valent pneumococcal polysaccharide vaccine, Quadrivalent split-virion influenza vaccine - Pneumococcal Polysaccharide Vaccine, Influenza Vaccines | Phase 4 | Not yet recruiting | The First Affiliated Hospital of Guangzhou Medical University | 1278 | 2026-11-01 | 2026-10-21 |
| Phase I/II Clinical Trial of 26-valent Pneumococcal Conjugate Vaccine 26-Valent pneumococcal conjugate vaccine, 23-Valent pneumococcal polysaccharide vaccine, 13-Valent pneumococcal conjugate vaccine - Pneumococcal Vaccines | Phase 1 / Phase 2 | Completed | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 450 | 2025-07-17 | 2026-03-30 |
| A Clinical Trial to Evaluate the Immunogenicity and Safety of the 23-valent Pneumococcal Polysaccharide Vaccine in Healthy People 23-valent pneumococcal polysaccharide vaccine, control pneumococcal polysaccharide vaccine - Pneumococcal Disease | Phase 3 | Recruiting | Aimei Vacin BioPharm (Zhejiang) Co., Ltd. | 1920 | 2023-09-08 | 2023-09-21 |
| A Clinical Trial to Observe the Safety of 23-Valent Pneumococcal Polysaccharide Vaccine in Target Population 23-valent pneumococcal polysaccharide vaccine, Influenza vaccine - Pneumococcal Infectious Disease | Completed | Sinovac Biotech Co., Ltd | 19267 | 2022-07-02 | 2025-07-17 | |
| Safety, Tolerability, and Immunogenicity of V110 or V114 Co-administered With a Booster Dose of mRNA-1273 in Healthy Adults (V110-911) V110, V114, mRNA-1273 - Pneumococcal Infection | Phase 3 | Completed | Merck Sharp & Dohme LLC | 850 | 2022-01-12 | 2025-07-18 |
| Post-marketing Safety Evaluation of Pneumococcal Vaccines Among Children and Elderly Adults. 10 or 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine, Influenza vaccine - Pneumococcal Vaccine Adverse Reaction | Unknown | Sungkyunkwan University | 1000000 | 2021-08-01 | 2020-09-16 | |
| Immunogenicity and Safety of an Inactivated COVID-19 Vaccine Inactivated COVID-19 Vaccine, 23-valent pneumococcal polysaccharide vaccine, Inactivated Hepatitis A Vaccine - COVID-19 | Phase 4 | Completed | Sinovac Research and Development Co., Ltd. | 270 | 2021-07-09 | 2022-04-14 |
| A Clinical Trial to Evaluate the Immunogenicity and Safety of PPV23 Vaccine Revaccinations in the Elderly 23-valent pneumococcal polysaccharide vaccine - Vaccination | Phase 4 | Completed | China National Biotec Group Company Limited | 331 | 2021-03-30 | 2022-02-16 |
| A Clinical Trial to Evaluate the Safety and Immunogenicity of PPV23 Vaccine Revaccinated in 60-70 Years Old 23-valent pneumococcal polysaccharide vaccine - Vaccination | Phase 4 | Completed | China National Biotec Group Company Limited | 330 | 2021-03-21 | 2022-02-16 |
| Clinical Trial of 23-valent Pneumococcal Polysaccharide Vaccine in Healthy Chinese Population Aged 2 Years and Above 23-valent pneumococcal polysaccharide vaccine, pneumococcal vaccine polyvalent - Pneumonia | Phase 1 | Completed | Ab&B Bio-tech Co., Ltd.JS | 144 | 2020-09-07 | 2026-01-02 |
| Immunogenicity and Safety of 23-Valent Pneumococcal Polysaccharide Vaccine in Healthy Volunteers Aged 2 Years and Above 23-Valent Pneumococcal Polysaccharide Vaccine - Pneumonia, Pneumococcal | Phase 3 | Completed | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 1940 | 2018-01-12 | 2020-02-20 |
| Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine - Rheumatoid Arthritis, Systemic Lupus | Phase 4 | Completed | Region Skane | 300 | 2016-06-14 | 2023-03-29 |
| Vaccination Response in Tecfidera-Treated Versus Interferon-Treated Participants With Relapsing Forms of Multiple Sclerosis. dimethyl fumarate, tetanus diphtheria toxoids vaccine, 23-valent pneumococcal polysaccharide vaccine - Relapsing Forms of Multiple Sclerosis | Phase 2 | Completed | Biogen | 71 | 2015-02-28 | 2017-06-02 |
| Safety and Immunogenicity of a 10 Valent Pneumococcal Conjugate Vaccine (SIILPCV10) in Healthy Adults, Toddlers, Infants SIILPCV10, Pneumovax 23, Prevenar 13 - Pneumococcal Disease | Phase 1 / Phase 2 | Completed | PATH | 346 | 2015-01-12 | 2019-08-02 |
| The Effect of Short-term Atorvastatin Treatment on Immune Responses to Pneumovax 23 Atorvastatin, Pneumovax 23, Placebo (lactose pill) - Healthy Controls | Phase 1 | Completed | University of Florida | 33 | 2014-06-01 | 2015-09-28 |
| Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults 23-valent pneumococcal polysaccharide vaccine, trivalent influenza vaccine, 23vPPV+TIV - Pneumococcal Infection, Influenza | Phase 4 | Completed | Jiangsu Province Centers for Disease Control and Prevention | 2225 | 2013-11-01 | 2014-02-13 |
| Pneumonia Vaccine in Aging HIV Positive Individuals 23-valent pneumococcal polysaccharide vaccine, 13-valent pneumococcal conjugate vaccine - Pneumococcal Infection | Early Phase 1 | Completed | University of Toledo Health Science Campus | 51 | 2013-07-01 | 2015-09-24 |
| A Phase 3 Trial Evaluating the Safety, Tolerability, and Immunogenicity of a 13-valent Pneumococcal Conjugate Vaccine in Japanese Elderly Adults Aged 65 Years Old and Older 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine - Pneumococcal Vaccines, Pneumococcal Conjugate Vaccine | Phase 3 | Completed | Pfizer | 764 | 2012-06-01 | 2013-09-20 |
| A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA) tocilizumab, methotrexate, 23-Valent Pneumococcal Polysaccharide Vaccine - Rheumatoid Arthritis | Phase 4 | Completed | Genentech, Inc. | 91 | 2010-09-01 | 2012-12-07 |
| Study Evaluating the Safety, Tolerability and Immunogenicity of 13vPnC as a 2-Dose Regimen or With 23vPS 13 valent Pneumococcal Conjugate Vaccine, 23-valent Pneumococcal Polysaccharide Vaccine - Pneumococcal Vaccines | Phase 3 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 720 | 2007-11-01 | 2011-07-22 |
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Pneumococcal Infections (7) · Arthritis, Rheumatoid (3) · Influenza, Human (2) · COVID-19 (1) · Pneumonia (1) · Pneumonia, Pneumococcal (1) · Sjogren's Syndrome (1) · Spondylarthritis (1) · Systemic Vasculitis (1)
Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd (2) · China National Biotec Group Company Limited (2) · Genentech, Inc. (2) · Ab&B Bio-tech Co., Ltd.JS (1) · Aimei Vacin BioPharm (Zhejiang) Co., Ltd. (1) · Biogen (1) · Jiangsu Province Centers for Disease Control and Prevention (1) · Merck Sharp & Dohme LLC (1) · PATH (1) · Pfizer (1) · Region Skane (1) · Sinovac Biotech Co., Ltd (1) · Sinovac Research and Development Co., Ltd. (1) · Sungkyunkwan University (1) · The First Affiliated Hospital of Guangzhou Medical University (1)
China (9) · United States (7) · Japan (1) · Puerto Rico (1) · South Korea (1) · The Gambia (1)
Ariella Kelman, M.D. (1) · Du Lin, Master (1) · Ed Clarke, MD PhD (1) · Jehns Martineus, MD (1) · Ju-Young Shin, PhD (1) · Li Zhang, Master (1) · Maria AJ Westerink, M.D. (1) · Mark L Brantly, MD (1) · Micki Klearman, M.D. (1) · Qianli Ma (1) · Xiang Guo (1) · Yanxia Wang (1)
PMID 11115712, PMID 1347058, PMID 20039397, PMID 24448345, PMID 24606865, PMID 2572650, PMID 29159204, PMID 30686636, PMID 3183430, PMID 31843266, PMID 32087733, PMID 3652522, PMID 37325662, PMID 40006738, PMID 40746543, PMID 41729368
R01AG045973 (1)