25 completed, 13 terminated, 6 active not recruiting, 6 recruiting. 26 Not applicable, 18 Phase 2, 5 Phase 1, 3 Early Phase 1, 1 Phase 3.
Follow Stage I Breast Cancer: new trials by email Literature Review of Stage I Breast Cancer trials Research Report on Stage I Breast Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Researching the Effect of Exercise on Cancer Exercise - Breast Cancer, Prostate Cancer | Not applicable | Recruiting | City of Hope Medical Center | 51 | 2026-10-30 | 2026-08-27 |
| Mindfulness-based Intervention for Depressive Symptoms Sent Via Text (MINDSET) MINDSET, Enhanced Usual Care (EUC) - Depression, Cancer | Not applicable | Not yet recruiting | Case Comprehensive Cancer Center | 76 | 2026-08-03 | 2026-01-23 |
| A Study of Disappearing Markers for Daily Radiation Treatment Delivery for Breast Cancer Patients. Magic Ink - Ductal Carcinoma in Situ, Stage I Breast Cancer | Not applicable | Recruiting | Barbara Ann Karmanos Cancer Institute | 30 | 2025-08-18 | 2025-09-18 |
| A Study of Revaree Plus in People With Breast Cancer Revaree Plus - Breast Cancer, Stage 0 Breast Cancer | Phase 4 | Recruiting | Memorial Sloan Kettering Cancer Center | 60 | 2025-06-20 | 2026-02-06 |
| TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients THRIVE, Health Education Support Program - Breast Cancer, Stage III Breast Cancer | Not applicable | Recruiting | Dana-Farber Cancer Institute | 270 | 2023-03-20 | 2026-07-17 |
| Improving Exercise Capacity With a Tailored Physical Activity Intervention Exercise with Trainerize application, Cardiopulmonary exercise testing, MRI scan - Non Hodgkin Lymphoma, Heart; Functional Disturbance | Not applicable | Active not recruiting | Wake Forest University Health Sciences | 105 | 2023-03-01 | 2026-09-09 |
| To Detect Cryoimmunologic Response Induced by Early Breast Cancer Ultrasound-guided Cryoablation (ICE-study) cryoablation - Cancer, Treatment-Related, Tumor of Breast | Not applicable | Completed | University of Roma La Sapienza | 20 | 2022-09-01 | 2023-02-14 |
| Partial Chest Wall Radiation Therapy After Surgery for Lymph Node Negative Breast Cancer Partial Chest Wall Radiation Therapy - Breast Cancer, Breast Cancer Female | Early Phase 1 | Withdrawn | Stony Brook University | 2022-07-15 | 2023-10-18 | |
| Comparison Between Prepectoral and Subpectoral Breast Reconstruction The breast reconstruction method after single-port insufflation endoscopic nipple-sparing mastectomy - Stage II Breast Cancer, Stage I Breast Cancer | Recruiting | Beijing Friendship Hospital | 88 | 2022-03-01 | 2023-04-27 | |
| Single Fraction Accelerated Partial Breast Irradiation vs. Five Fraction Accelerated Partial Breast Irradiation for Low-risk Stage 0 and I Breast Carcinoma External Beam Accelerated Partial Breast Irradiation - Breast Carcinoma, Breast Cancer | Not applicable | Active not recruiting | Washington University School of Medicine | 134 | 2021-08-12 | 2026-05-06 |
| De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA) Radiation and Endocrine Therapy (Tamoxifen, Anastrozol, Letrozole, Exemestane), Endocrine Therapy (Tamoxifen, Anastrozol, Letrozole, Exemestane) - Stage I Breast Cancer | Phase 3 | Recruiting | NRG Oncology | 1670 | 2021-06-23 | 2026-04-23 |
| Hypofractionated Radiation Therapy vs Standard Treatment in Breast Cancer. Hypofractionated radiotherapy - Ductal Breast Carcinoma in Situ, Invasive Breast Cancer | Not applicable | Active not recruiting | Coordinación de Investigación en Salud, Mexico | 72 | 2021-04-26 | 2026-03-23 |
| Niraparib + Dostarlimab In BRCA Mutated Breast Cancer Niraparib, Dostarlimab - Stage I Breast Cancer, Stage II Breast Cancer | Phase 2 | Active not recruiting | Dana-Farber Cancer Institute | 66 | 2021-01-21 | 2026-09-24 |
| Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy Trastuzumab and pertuzumab Subcutaneous Fixed-Dose Combination - HER2-positive Breast Cancer, Stage I Breast Cancer | Phase 2 | Terminated | Fundacio Clinic Barcelona | 5 | 2020-09-23 | 2026-01-06 |
| Exercise Intervention in Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer Exercise Intervention, Informational Intervention, Laboratory Biomarker Analysis - Cancer Survivor, Central Obesity | Not applicable | Withdrawn | University of Southern California | 2019-07-29 | 2019-10-24 | |
| Acupuncture Pilot Study for Cancer-related Cognitive Function Acupuncture, Sham Acupuncture, 16 week waiting period + optional Acupuncture - Stage I Breast Cancer, Stage II Breast Cancer | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 48 | 2019-07-01 | 2026-08-12 |
| Living Well After Breast Surgery Breast reconstruction decision aid, Educational website - Breast Cancer Female, Stage I Breast Cancer | Not applicable | Completed | University of Texas at Austin | 17 | 2019-02-18 | 2021-11-02 |
| Biomarker Study of the Antitumoral Activity of Denosumab in the Pre- Operative Setting of Early Breast Cancer Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA] - Breast Neoplasm Female, Stage I Breast Cancer | Early Phase 1 | Unknown | Institut Català d'Oncologia | 60 | 2018-07-05 | 2021-11-03 |
| Hypofractionated Radiation Therapy in Treating Patients With Stage 0-IIB Breast Cancer Hypofractionated Radiation Therapy - Ductal Breast Carcinoma In Situ, Invasive Breast Carcinoma | Phase 2 | Completed | University of Utah | 102 | 2017-12-12 | 2025-12-30 |
| Exercise in Targeting Metabolic Dysregulation in Stage I-III Breast or Prostate Cancer Survivors Exercise Intervention, Laboratory Biomarker Analysis, Polar heart rate monitor - Cancer Survivor, No Evidence of Disease | Not applicable | Terminated | University of Southern California | 23 | 2017-08-17 | 2025-09-29 |
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Breast Neoplasms (56) · Carcinoma, Intraductal, Noninfiltrating (11) · Breast Carcinoma In Situ (8) · Prostatic Neoplasms (5) · Colorectal Neoplasms (4) · Breast Neoplasms, Male (3) · Carcinoma, Ductal, Breast (3) · Carcinoma, Lobular (2) · Depression (2) · Neoplasms (2) · Triple Negative Breast Neoplasms (2) · Arthralgia (1) · Hodgkin Disease (1) · Inflammatory Breast Neoplasms (1) · Lymphoma, Non-Hodgkin (1)
Breast Diseases (56) · Neoplasms by Site (56) · Skin Diseases (56) · Skin and Connective Tissue Diseases (56) · Neoplasms (54) · Neoplasms by Histologic Type (17) · Carcinoma (16) · Carcinoma in Situ (16) · Neoplasms, Glandular and Epithelial (16) · Adenocarcinoma (11) · Neoplasms, Ductal, Lobular, and Medullary (11) · Breast Carcinoma In Situ (8) · Genital Diseases (6) · Urogenital Diseases (6) · Urogenital Neoplasms (6)
Cyclophosphamide (4) · Letrozole (4) · Acupuncture Therapy (3) · Capecitabine (3) · Doxorubicin (3) · Exercise (3) · Radiation (3) · Radiotherapy (3) · Anastrozole (2) · Early Intervention, Educational (2) · Paclitaxel (2) · Psychiatric Rehabilitation (2) · Radiation Dose Hypofractionation (2) · Tamoxifen (2) · Therapeutics (2)
Case Comprehensive Cancer Center (4) · City of Hope Medical Center (4) · Dana-Farber Cancer Institute (4) · University of Southern California (4) · Wake Forest University Health Sciences (4) · National Cancer Institute (NCI) (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · University of Washington (3) · Memorial Sloan Kettering Cancer Center (2) · Rutgers, The State University of New Jersey (2) · Abramson Cancer Center at Penn Medicine (1) · Avelas Biosciences, Inc. (1) · Barbara Ann Karmanos Cancer Institute (1) · Beijing Friendship Hospital (1) · Coordinación de Investigación en Salud, Mexico (1)
United States (50) · Spain (2) · Canada (1) · China (1) · Hong Kong (1) · Italy (1) · Japan (1) · Mexico (1) · Norway (1)
Hannah Linden (3) · Christina Dieli-Conwright, Ph.D. (2) · Vered Stearns (2) · Aleix Prat, MD (1) · Alexander Stessin, MD PhD (1) · Andrea Barsevick, PhD (1) · Anna Wu (1) · Charles Kunos, MD (1) · Chelsea Siwik, PhD (1) · Christina Dieli-Conwright, PhD (1) · Craig Bunnell, MD (1) · David Mattson (1) · Dawn Hershman (1) · Elisa Port (1) · Erica L. Mayer, MD, MPH (1)
PMID 15770533, PMID 22827973, PMID 24210070, PMID 24464780, PMID 24708832, PMID 27566765, PMID 28050693, PMID 29356607, PMID 29440043, PMID 30340503, PMID 30920602, PMID 30971205, PMID 31309977, PMID 32297442, PMID 33292676, PMID 33929533, PMID 34413391, PMID 35795051, PMID 36791166, PMID 38979716, PMID 39436590, PMID 40314623, PMID 40443562
P30CA014089 (3), 2016 (1), N01CN35159 (1), P30CA006973 (1), P30CA008748 (1), P30CA012197 (1), P30CA016056 (1), P30CA016672 (1), P30CA033572 (1), P30CA072720 (1), R01CA176838 (1), R21CA187643 (1), R33CA226960 (1), U01CA070095 (1), U01CA271277 (1)