6 completed, 2 active not recruiting. 8 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 6, Active not recruiting 2 |
Follow Recurrent Melanoma: new trials by email Literature Review of Recurrent Melanoma trials Research Report on Recurrent Melanoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma Biospecimen Collection, Computed Tomography, Dabrafenib Mesylate - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8 | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 267 | 2015-09-08 | 2026-10-26 |
| Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery Ipilimumab, Quality-of-Life Assessment, Recombinant Interferon Alfa-2b - Melanoma of Unknown Primary, Recurrent Melanoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 1673 | 2011-06-17 | 2026-10-22 |
| Carboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery Carboplatin, Laboratory Biomarker Analysis, Paclitaxel - Mucosal Melanoma, Recurrent Melanoma | Phase 3 | Completed | National Cancer Institute (NCI) | 823 | 2005-06-01 | 2015-10-19 |
| Fotemustine and Dacarbazine Versus Dacarbazine +/- Alpha Interferon in Advanced Malignant Melanoma Dacarbazine, Fotemustine, Interferon Alfa-2b - Malignant Melanoma, Recurrent Melanoma | Phase 3 | Completed | National Cancer Institute, Naples | 269 | 2002-04-01 | 2023-04-11 |
| Sargramostim, Vaccine Therapy, or Sargramostim and Vaccine Therapy in Preventing Disease Recurrence in Patients With Melanoma That Has Been Removed By Surgery Laboratory Biomarker Analysis, Placebo, Sargramostim - Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma | Phase 3 | Completed | National Cancer Institute (NCI) | 815 | 2000-02-23 | 2026-06-24 |
| Aldesleukin With or Without Vaccine Therapy in Treating Patients With Locally Advanced or Metastatic Melanoma Aldesleukin, gp100 Antigen, Montanide ISA 51 VG - Recurrent Melanoma, Stage IIIA Skin Melanoma | Phase 3 | Completed | National Cancer Institute (NCI) | 185 | 1999-12-01 | 2017-11-20 |
| Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Locally Advanced Melanoma of the Arm or Leg isolated limb perfusion, melphalan, recombinant tumor necrosis factor family protein - Recurrent Melanoma, Stage III Melanoma | Phase 3 | Completed | National Cancer Institute (NCI) | 216 | 1999-03-01 | 2013-07-16 |
| Chemotherapy With or Without Immunotherapy in Treating Patients With Stage III or Stage IV Melanoma allovectin-7, allovectin-7/dacarbazine, dacarbazine - Stage IV Melanoma, Stage III Melanoma | Phase 3 | Completed | Vical | 1998-07-01 | 2008-07-25 |
Melanoma (8) · Neoplasms (1) · Skin Neoplasms (1) · Uveal Melanoma (1)
Neoplasms by Histologic Type (8) · Neoplasms by Site (8) · Neoplasms, Germ Cell and Embryonal (8) · Neoplasms, Nerve Tissue (8) · Neuroectodermal Tumors (8) · Neuroendocrine Tumors (8) · Nevi and Melanomas (8) · Skin Diseases (8) · Skin and Connective Tissue Diseases (8) · Neoplasms (7) · Skin Neoplasms (7) · Eye Diseases (1) · Eye Neoplasms (1) · Uveal Diseases (1) · Uveal Neoplasms (1)
CTLA-4 Antigen (2) · Dacarbazine (2) · Interferon alpha-2 (2) · Ipilimumab (2) · Allovectin-7 (1) · Carboplatin (1) · Colony-Stimulating Factors (1) · Interleukin-2 (1) · Introns (1) · Melphalan (1) · Nivolumab (1) · Paclitaxel (1) · Sorafenib (1) · Specimen Handling (1) · Taxes (1)
National Cancer Institute (NCI) (6) · National Cancer Institute, Naples (1) · Vical (1)
United States (7) · Australia (1) · Canada (1)
Ahmad Tarhini (1) · Antonio Daponte, M.D. (1) · Cherie Smith (1) · David H Lawson (1) · Douglas Fraker (1) · Douglas Schwartzentruber (1) · Keith Flaherty (1) · Michael B Atkins (1) · Paolo A Ascierto, M.D., Ph.D. (1) · Simona Signoriello, M.D. (1)
PMID 21631324, PMID 23248256, PMID 23402397, PMID 25649350, PMID 26351350, PMID 29784747, PMID 35659704, PMID 36029412, PMID 36166727
U10CA021115 (3), U10CA180820 (3), P50CA121973 (1), U10CA076001 (1), U24CA196172 (1)