13 completed, 6 recruiting, 3 active not recruiting, 3 unknown. 5 Phase 1, 5 Phase 2, 4 Phase 3, 3 Phase 4, 1 Not applicable.
Follow Monkeypox: new trials by email Literature Review of Monkeypox trials Research Report on Monkeypox
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Understanding MPXV Viral Clearance, Transmission Dynamics, and Mpox Vaccine Effectiveness in West Africa : Guinea Mpox (Monkeypox), Monkeypox | Not yet recruiting | London School of Hygiene and Tropical Medicine | 992 | 2026-04-16 | 2026-04-16 | |
| Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BSY001 After Single/Multiple Doses. BSY001 for Injection (37.5mg), BSY001 for Injection (75 mg), BSY001 for Injection (150 mg) - Smallpox, Cowpox | Phase 1 | Recruiting | China National Biotec Group Company Limited | 76 | 2025-08-28 | 2026-01-29 |
| Evaluation of Long-term Immunogenicity of a Boost Dose of MVA-BN Vaccine Monkeypox | Recruiting | Assistance Publique - Hôpitaux de Paris | 90 | 2025-05-07 | 2025-05-15 | |
| A Study Evaluating the Safety and Immunogenicity of MVA Strain Monkeypox Attenuated Live Vaccine MVA strain monkeypox attenuated live vaccine (low dose), MVA strain monkeypox attenuated live vaccine (high dose), Placebo - Monkeypox | Phase 1 | Recruiting | Shanghai Institute Of Biological Products | 120 | 2025-01-22 | 2025-10-03 |
| Ocular Complications of Mpox in the Democratic Republic Congo Monkeypox, Mpox (Monkeypox) | Completed | Institute of Tropical Medicine, Belgium | 320 | 2024-10-28 | 2026-03-12 | |
| Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT Bavarian Nordic smallpox vaccine, Typhoid VI Polysaccharide Vaccine Injectable Solution - Monkeypox | Phase 4 | Active not recruiting | McMaster University | 3000 | 2024-09-17 | 2026-08-12 |
| European Trial Into Mpox Infection Tecovirimat Oral Capsule, Placebo - Monkeypox | Phase 4 | Unknown | Miquel Ekkelenkamp | 150 | 2024-08-09 | 2025-03-28 |
| Observational, Prospective, Cohort Study of Mpox Infection in Brazil (NETPOX) Viral genomic, Untargeted Metabolomics - Monkeypox, MPOX | Recruiting | Hospital Israelita Albert Einstein | 80 | 2024-07-16 | 2024-07-17 | |
| Efficacy/Effectiveness, Safety, and Immunogenicity of LC16m8 Mpox Vaccine in Colombia LC16m8 - Monkeypox | Phase 3 | Active not recruiting | Universidad Nacional de Colombia | 8686 | 2023-12-16 | 2025-09-04 |
| Morbidity, Mortality And Risk Factors of Mpox in HIV Negative High Risk Sexual Health Clinic Attenders and People Living With HIV No intervention - Monkeypox, HIV Coinfection | Completed | NEAT ID Foundation | 2000 | 2023-12-01 | 2025-08-13 | |
| A Clinical Study Investigating the Safety and Immune Responses After Immunization With Investigational Monkeypox Vaccines BNT166a - Monkeypox | Phase 1 / Phase 2 | Completed | BioNTech SE | 96 | 2023-09-21 | 2026-09-15 |
| Tecovirimat in Non-hospitalized Patients With Monkeypox Tecovirimat, Placebo - Monkeypox | Phase 3 | Suspended | Marina Klein | 120 | 2023-08-14 | 2026-03-04 |
| Assessment of Safety Profile of MVA-BN Vaccine in the PALM-007 Study in DRC MVA-BN vaccine - Monkeypox | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 500 | 2023-03-23 | 2026-02-12 |
| A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox JYNNEOS - Monkeypox | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 450 | 2023-03-22 | 2026-03-27 |
| Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV Monkeypox, HIV Infections | Terminated | Centers for Disease Control and Prevention | 100 | 2023-03-17 | 2026-05-05 | |
| Mpox Paediatric and Adolescent Clinical Study Monkey Pox, Monkeypox | Completed | PENTA Foundation | 1108 | 2023-03-17 | 2026-08-31 | |
| Assessment of the Efficacy and Safety of Tecovirimat in Patients With Monkeypox Virus Disease Tecovirimat, Placebo - Monkeypox, Mpox | Phase 3 | Active not recruiting | ANRS, Emerging Infectious Diseases | 480 | 2023-03-03 | 2026-05-26 |
| New York City Observational Study of Mpox Immunity Monkeypox, Mpox | Enrolling by invitation | NYU Langone Health | 188 | 2022-11-11 | 2026-08-27 | |
| Pilot Study to Detect Monkey Pox Virus in Sperm: POXSPERM Samples - Monkeypox | Not applicable | Unknown | University Hospital, Toulouse | 30 | 2022-11-01 | 2022-11-29 |
| Tecovirimat for Treatment of Monkeypox Virus Tecovirimat Oral Capsule, Placebo - Monkeypox | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 597 | 2022-10-10 | 2025-10-09 |
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Mpox, Monkeypox (31) · Smallpox (5) · Cowpox (4) · HIV Infections (2) · Acquired Immunodeficiency Syndrome (1) · Poxviridae Infections (1)
Animal Diseases (31) · DNA Virus Infections (31) · Infections (31) · Primate Diseases (31) · Rodent Diseases (31) · Virus Diseases (31) · Poxviridae Infections (30) · Blood-Borne Infections (2) · Communicable Diseases (2) · Genital Diseases (2) · Immune System Diseases (2) · Immunologic Deficiency Syndromes (2) · Lentivirus Infections (2) · RNA Virus Infections (2) · Retroviridae Infections (2)
tecovirimat (5) · smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (4) · Blood Specimen Collection (1) · Injections (1) · NIOCH-14 (1) · Sampling Studies (1) · Smallpox Vaccine (1) · smallpox vaccine LC16m8 (1)
National Institute of Allergy and Infectious Diseases (NIAID) (4) · Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector" (3) · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia (2) · Institute of Tropical Medicine, Belgium (2) · ANRS, Emerging Infectious Diseases (1) · Assistance Publique - Hôpitaux de Paris (1) · BioNTech SE (1) · Centers for Disease Control and Prevention (1) · China National Biotec Group Company Limited (1) · Hospital Israelita Albert Einstein (1) · London School of Hygiene and Tropical Medicine (1) · Marina Klein (1) · McMaster University (1) · Miquel Ekkelenkamp (1) · NEAT ID Foundation (1)
United States (6) · Democratic Republic of the Congo (5) · Spain (5) · France (4) · Russia (3) · United Kingdom (3) · Belgium (2) · Brazil (2) · Canada (2) · China (2) · Netherlands (2) · Nigeria (2) · Argentina (1) · Colombia (1) · Germany (1)
Vladimir I. Kuzubov, PhD (3) · Agam Rao, MD (1) · Angelica Kottkamp, MD (1) · Brian Epling, MD (1) · Christine Hughes, PhD (1) · Christopher Meadows, FRCP FRCA (1) · Darrell HS Tan, MD (1) · Deborah Watson-Jones, PhD (1) · Edward M Choi, PhD (1) · Faisal Minhaj, Pharm.D. (1) · Heinz Weidenthaler (1) · Henrique Fonseca (1) · Irina V Krasil'nikova, PhD (1)
PMID 36263798, PMID 38366591, PMID 40162783, PMID 40239067, PMID 41319397, PMID 42209512, PMID 42235570, PMID 42532635