Lymphoma, Large B-Cell, Diffuse: Clinical Trials

18 trials for Lymphoma, Large B-Cell, Diffuse, newest first

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18 terminated. 18 Phase 3, 3 Phase 2.

By phase and status

PhaseTrialsStatus
Phase 318Terminated 18
Phase 23Terminated 3

Follow Lymphoma, Large B-Cell, Diffuse: new trials by email Literature Review of Lymphoma, Large B-Cell, Diffuse trials Research Report on Lymphoma, Large B-Cell, Diffuse

Trials (filtered) newest first · largest first

All 18 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

TrialPhaseStatusSponsorEnrollmentStartUpdated
NKTR-255 vs Placebo Following CD19-directed CAR-T Therapy in Patients With Relapsed/Refractory Large B-cell Lymphoma
NKTR-255 at 1.5 µg/kg, NKTR-255 at 3.0 μg/kg, NKTR-255 at 3.0/6.0 μg/kg - Non-Hodgkin Lymphoma, Relapsed/Refractory Diffuse Large B-cell Lymphoma
Phase 2 / Phase 3TerminatedNektar Therapeutics152023-02-232026-10-16
A Study to Evaluate the Efficacy and Safety of Polatuzumab Vedotin in Combination With Bendamustine and Rituximab Compared With Bendamustine and Rituximab Alone in Chinese Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL).
Polatuzumab Vedotin, Bendamustine, Rituximab - Diffuse, Large B-Cell, Lymphoma
Phase 3TerminatedHoffmann-La Roche422020-07-102023-03-03
A Study to Compare the Efficacy and Safety of JHL1101 Versus Rituximab in Patients With Previously Untreated Diffuse Large B-Cell Lymphoma (DLBCL)
JHL1101, MabThera - Diffuse Large B-Cell Lymphoma
Phase 3TerminatedJHL Biotech, Inc.82018-11-132020-01-09
Avelumab In Combination Regimens That Include An Immune Agonist, Epigenetic Modulator, CD20 Antagonist and/or Conventional Chemotherapy in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL)
Avelumab, Utomilumab, Rituximab - Diffuse Large B-Cell Lymphoma
Phase 3TerminatedPfizer292016-12-162020-12-17
Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma
Ublituximab, Umbralisib, Bendamustine - Diffuse Large B-Cell Lymphoma, Follicular Lymphoma
Phase 2 / Phase 3TerminatedTG Therapeutics, Inc.7102016-05-252022-07-21
BEAM vs. 90-Yttrium Ibritumomab Tiuxetan (Zevalin®)/BEAM With ASCT for Relapsed DLBCL
90-Yttrium Ibritumomab tiuxetan, Carmustine, Etoposide - Recurrent Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
Phase 3TerminatedCity of Hope Medical Center32015-01-012018-03-12
Study of Zevalin Versus Observation in Participants at Least 60 Years Old With Newly Diagnosed Diffuse Large B-cell Lymphoma in Positron Emission Tomography (PET)-Negative Complete Remission After Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) or R-CHOP-like Therapy
Zevalin, Y-90-Zevalin, Rituximab - Diffuse Large B-cell Lymphoma, Follicle Center Lymphoma
Phase 3TerminatedSpectrum Pharmaceuticals, Inc792012-04-192021-12-16
A Study of Obinutuzumab in Combination With CHOP Chemotherapy Versus Rituximab With CHOP in Participants With CD20-Positive Diffuse Large B-Cell Lymphoma (GOYA)
Rituximab, Obinutuzumab, Cyclophosphamide - Diffuse Large B-Cell Lymphoma
Phase 3TerminatedHoffmann-La Roche14182011-07-262019-04-12
A Study Of Inotuzumab Ozogamicin Plus Rituximab For Relapsed/Refractory Aggressive Non-Hodgkin Lymphoma Patients Who Are Not Candidates For Intensive High-Dose Chemotherapy
Inotuzumab ozogamicin, Rituximab, rituximab + gemcitabine - Lymphoma, Non-Hodgkin
Phase 3TerminatedPfizer3382011-04-042019-01-08
Study Comparing Zevalin Regimen With no Further Treatment in Patients With Diffuse Large B-cell Lymphoma.
Zevalin - Lymphoma, Large Cell, Diffuse
Phase 3TerminatedSpectrum Pharmaceuticals, Inc682006-05-012022-01-19
Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant
moxifloxacin hydrochloride, Placebo - Breast Cancer, Chronic Myeloproliferative Disorders
Phase 3TerminatedOHSU Knight Cancer Institute2402006-05-012017-05-09
Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD)
mycophenolate mofetil, placebo - Cancer
Phase 3TerminatedMartin, Paul1512004-05-012013-05-03
ACVBP Versus ACVBP Plus Rituximab in Low Risk Localized Diffuse Large B-cell Lymphoma
rituximab - Diffuse Large Cell Lymphoma
Phase 3TerminatedLymphoma Study Association2232003-12-012017-03-13
Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma
CHOP regimen, EPOCH regimen, cyclophosphamide - Lymphoma
Phase 2 / Phase 3TerminatedEuropean Organisation for Research and Treatment of Cancer - EORTC32003-03-012012-09-24
R-ACVBP Versus R-CHOP in Patients Aged 60-65 With Diffuse Large B-cell Lymphoma
Rituximab, Doxorubicin, Cyclophosphamide - Lymphoma, Large-Cell, Diffuse
Phase 3TerminatedLymphoma Study Association1382001-10-162018-08-23
S0019 Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
filgrastim, rituximab, carboplatin - Lymphoma
Phase 3TerminatedSWOG Cancer Research Network72000-10-012013-04-10
Efficacy Study of Rituximab After ASCT in High-Risk Diffuse Large B-Cell Lymphoma
ACVBP, ACE, rituximab - CD20-Positive Large B-Cell Lymphoma
Phase 3TerminatedLymphoma Study Association4301999-10-012005-09-15
Prevention of Graft-Versus-Host Disease in Patients With Advanced Leukemia or Lymphoma Who Are Eligible for Peripheral Stem Cell Transplantation
cyclosporine, cyclosporine and methotrexate - Leukemia, Lymphoma
Phase 3TerminatedBaxalta now part of Shire1051997-04-012021-05-06

Narrower conditions

Lymphoma (7)  ·  Lymphoma, Non-Hodgkin (7)  ·  Lymphoma, Follicular (5)  ·  Burkitt Lymphoma (4)  ·  Leukemia, Lymphocytic, Chronic, B-Cell (4)  ·  Lymphoma, B-Cell, Marginal Zone (4)  ·  Lymphoma, Mantle-Cell (4)  ·  Leukemia, Myeloid, Accelerated Phase (3)  ·  Leukemia, Myeloid, Chronic-Phase (3)  ·  Lymphoma, Large-Cell, Immunoblastic (3)  ·  Precursor Cell Lymphoblastic Leukemia-Lymphoma (3)  ·  Blast Crisis (2)  ·  Breast Neoplasms (2)  ·  Carcinoma, Ovarian Epithelial (2)

Broader conditions

Hemic and Lymphatic Diseases (18)  ·  Immune System Diseases (17)  ·  Immunoproliferative Disorders (17)  ·  Lymphatic Diseases (17)  ·  Lymphoma, B-Cell (17)  ·  Lymphoproliferative Disorders (17)  ·  Neoplasms by Histologic Type (17)  ·  Neoplasms (16)  ·  Lymphoma (11)  ·  Lymphoma, Non-Hodgkin (11)  ·  Hematologic Diseases (5)  ·  Leukemia, Lymphoid (5)  ·  Chronic Disease (4)  ·  DNA Virus Infections (4)  ·  Disease Attributes (4)

Interventions

Rituximab (11)  ·  Bendamustine Hydrochloride (3)  ·  Cyclophosphamide (3)  ·  Doxorubicin (3)  ·  Etoposide (3)  ·  Prednisone (3)  ·  Vincristine (3)  ·  ibritumomab tiuxetan (3)  ·  Gemcitabine (2)  ·  Azacitidine (1)  ·  Bleomycin (1)  ·  Carboplatin (1)  ·  Carmustine (1)  ·  Cyclosporine (1)  ·  Cytarabine (1)

Sponsors

Lymphoma Study Association (3)  ·  Hoffmann-La Roche (2)  ·  Pfizer (2)  ·  Spectrum Pharmaceuticals, Inc (2)  ·  Baxalta now part of Shire (1)  ·  City of Hope Medical Center (1)  ·  European Organisation for Research and Treatment of Cancer - EORTC (1)  ·  JHL Biotech, Inc. (1)  ·  Martin, Paul (1)  ·  Nektar Therapeutics (1)  ·  OHSU Knight Cancer Institute (1)  ·  SWOG Cancer Research Network (1)  ·  TG Therapeutics, Inc. (1)

Countries

United States (12)  ·  Belgium (7)  ·  France (6)  ·  Spain (6)  ·  United Kingdom (6)  ·  Australia (5)  ·  Canada (5)  ·  Italy (5)  ·  Poland (5)  ·  South Korea (4)  ·  Switzerland (4)  ·  Austria (3)  ·  China (3)  ·  Germany (3)  ·  Hungary (3)

Top investigators

Amrita Y. Krishnan MD, MD (1)  ·  Corinne Haioun (1)  ·  Corinne Haioun, MD (1)  ·  David G. Maloney, MD, PhD (1)  ·  Felix Reyes, MD (1)  ·  Herve Tilly, MD (1)  ·  Joseph Bubalo, PharmD, BCPS, BCOP (1)  ·  Jun Zhu, MD/PhD (1)  ·  Nicolas Ketterer, MD (1)  ·  Owen A O'Connor, MD, PhD (1)  ·  Paul J. Martin, MD (1)

Results publications

PMID 26373676, PMID 19270260, PMID 27282998, PMID 30341058, PMID 30617197, PMID 30770362, PMID 31053601, PMID 32505213, PMID 33054054, PMID 33651099, PMID 33683917, PMID 34323957, PMID 34323958, PMID 34687398, PMID 35962459, PMID 37702406, PMID 38498084, PMID 38843483, PMID 39962481, PMID 42699559

NIH funding

2016 (1), P30CA069533 (1), U10CA032102 (1)