18 terminated. 18 Phase 3, 3 Phase 2.
By phase and status
Follow Lymphoma, Large B-Cell, Diffuse: new trials by email Literature Review of Lymphoma, Large B-Cell, Diffuse trials Research Report on Lymphoma, Large B-Cell, Diffuse
Trials (filtered) newest first · largest first
All 18 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
NKTR-255 vs Placebo Following CD19-directed CAR-T Therapy in Patients With Relapsed/Refractory Large B-cell Lymphoma NKTR-255 at 1.5 µg/kg, NKTR-255 at 3.0 μg/kg, NKTR-255 at 3.0/6.0 μg/kg - Non-Hodgkin Lymphoma, Relapsed/Refractory Diffuse Large B-cell Lymphoma | Phase 2 / Phase 3 | Terminated | 15 | 2023-02-23 | 2026-10-16 |
A Study to Evaluate the Efficacy and Safety of Polatuzumab Vedotin in Combination With Bendamustine and Rituximab Compared With Bendamustine and Rituximab Alone in Chinese Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL). Polatuzumab Vedotin, Bendamustine, Rituximab - Diffuse, Large B-Cell, Lymphoma | Phase 3 | Terminated | 42 | 2020-07-10 | 2023-03-03 |
A Study to Compare the Efficacy and Safety of JHL1101 Versus Rituximab in Patients With Previously Untreated Diffuse Large B-Cell Lymphoma (DLBCL) JHL1101, MabThera - Diffuse Large B-Cell Lymphoma | Phase 3 | Terminated | 8 | 2018-11-13 | 2020-01-09 |
Avelumab In Combination Regimens That Include An Immune Agonist, Epigenetic Modulator, CD20 Antagonist and/or Conventional Chemotherapy in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL) Avelumab, Utomilumab, Rituximab - Diffuse Large B-Cell Lymphoma | Phase 3 | Terminated | 29 | 2016-12-16 | 2020-12-17 |
Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma Ublituximab, Umbralisib, Bendamustine - Diffuse Large B-Cell Lymphoma, Follicular Lymphoma | Phase 2 / Phase 3 | Terminated | 710 | 2016-05-25 | 2022-07-21 |
BEAM vs. 90-Yttrium Ibritumomab Tiuxetan (Zevalin®)/BEAM With ASCT for Relapsed DLBCL 90-Yttrium Ibritumomab tiuxetan, Carmustine, Etoposide - Recurrent Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma | Phase 3 | Terminated | 3 | 2015-01-01 | 2018-03-12 |
Study of Zevalin Versus Observation in Participants at Least 60 Years Old With Newly Diagnosed Diffuse Large B-cell Lymphoma in Positron Emission Tomography (PET)-Negative Complete Remission After Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) or R-CHOP-like Therapy Zevalin, Y-90-Zevalin, Rituximab - Diffuse Large B-cell Lymphoma, Follicle Center Lymphoma | Phase 3 | Terminated | 79 | 2012-04-19 | 2021-12-16 |
A Study of Obinutuzumab in Combination With CHOP Chemotherapy Versus Rituximab With CHOP in Participants With CD20-Positive Diffuse Large B-Cell Lymphoma (GOYA) Rituximab, Obinutuzumab, Cyclophosphamide - Diffuse Large B-Cell Lymphoma | Phase 3 | Terminated | 1418 | 2011-07-26 | 2019-04-12 |
A Study Of Inotuzumab Ozogamicin Plus Rituximab For Relapsed/Refractory Aggressive Non-Hodgkin Lymphoma Patients Who Are Not Candidates For Intensive High-Dose Chemotherapy Inotuzumab ozogamicin, Rituximab, rituximab + gemcitabine - Lymphoma, Non-Hodgkin | Phase 3 | Terminated | 338 | 2011-04-04 | 2019-01-08 |
Study Comparing Zevalin Regimen With no Further Treatment in Patients With Diffuse Large B-cell Lymphoma. Zevalin - Lymphoma, Large Cell, Diffuse | Phase 3 | Terminated | 68 | 2006-05-01 | 2022-01-19 |
Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant moxifloxacin hydrochloride, Placebo - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 3 | Terminated | 240 | 2006-05-01 | 2017-05-09 |
Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) mycophenolate mofetil, placebo - Cancer | Phase 3 | Terminated | 151 | 2004-05-01 | 2013-05-03 |
ACVBP Versus ACVBP Plus Rituximab in Low Risk Localized Diffuse Large B-cell Lymphoma rituximab - Diffuse Large Cell Lymphoma | Phase 3 | Terminated | 223 | 2003-12-01 | 2017-03-13 |
Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma CHOP regimen, EPOCH regimen, cyclophosphamide - Lymphoma | Phase 2 / Phase 3 | Terminated | 3 | 2003-03-01 | 2012-09-24 |
R-ACVBP Versus R-CHOP in Patients Aged 60-65 With Diffuse Large B-cell Lymphoma Rituximab, Doxorubicin, Cyclophosphamide - Lymphoma, Large-Cell, Diffuse | Phase 3 | Terminated | 138 | 2001-10-16 | 2018-08-23 |
S0019 Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma filgrastim, rituximab, carboplatin - Lymphoma | Phase 3 | Terminated | 7 | 2000-10-01 | 2013-04-10 |
Efficacy Study of Rituximab After ASCT in High-Risk Diffuse Large B-Cell Lymphoma ACVBP, ACE, rituximab - CD20-Positive Large B-Cell Lymphoma | Phase 3 | Terminated | 430 | 1999-10-01 | 2005-09-15 |
Prevention of Graft-Versus-Host Disease in Patients With Advanced Leukemia or Lymphoma Who Are Eligible for Peripheral Stem Cell Transplantation cyclosporine, cyclosporine and methotrexate - Leukemia, Lymphoma | Phase 3 | Terminated | 105 | 1997-04-01 | 2021-05-06 |
Narrower conditions
Lymphoma (7) · Lymphoma, Non-Hodgkin (7) · Lymphoma, Follicular (5) · Burkitt Lymphoma (4) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Lymphoma, B-Cell, Marginal Zone (4) · Lymphoma, Mantle-Cell (4) · Leukemia, Myeloid, Accelerated Phase (3) · Leukemia, Myeloid, Chronic-Phase (3) · Lymphoma, Large-Cell, Immunoblastic (3) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (3) · Blast Crisis (2) · Breast Neoplasms (2) · Carcinoma, Ovarian Epithelial (2)
Broader conditions
Hemic and Lymphatic Diseases (18) · Immune System Diseases (17) · Immunoproliferative Disorders (17) · Lymphatic Diseases (17) · Lymphoma, B-Cell (17) · Lymphoproliferative Disorders (17) · Neoplasms by Histologic Type (17) · Neoplasms (16) · Lymphoma (11) · Lymphoma, Non-Hodgkin (11) · Hematologic Diseases (5) · Leukemia, Lymphoid (5) · Chronic Disease (4) · DNA Virus Infections (4) · Disease Attributes (4)
Interventions
Rituximab (11) · Bendamustine Hydrochloride (3) · Cyclophosphamide (3) · Doxorubicin (3) · Etoposide (3) · Prednisone (3) · Vincristine (3) · ibritumomab tiuxetan (3) · Gemcitabine (2) · Azacitidine (1) · Bleomycin (1) · Carboplatin (1) · Carmustine (1) · Cyclosporine (1) · Cytarabine (1)
Sponsors
Lymphoma Study Association (3) · Hoffmann-La Roche (2) · Pfizer (2) · Spectrum Pharmaceuticals, Inc (2) · Baxalta now part of Shire (1) · City of Hope Medical Center (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · JHL Biotech, Inc. (1) · Martin, Paul (1) · Nektar Therapeutics (1) · OHSU Knight Cancer Institute (1) · SWOG Cancer Research Network (1) · TG Therapeutics, Inc. (1)
Countries
United States (12) · Belgium (7) · France (6) · Spain (6) · United Kingdom (6) · Australia (5) · Canada (5) · Italy (5) · Poland (5) · South Korea (4) · Switzerland (4) · Austria (3) · China (3) · Germany (3) · Hungary (3)
Top investigators
Amrita Y. Krishnan MD, MD (1) · Corinne Haioun (1) · Corinne Haioun, MD (1) · David G. Maloney, MD, PhD (1) · Felix Reyes, MD (1) · Herve Tilly, MD (1) · Joseph Bubalo, PharmD, BCPS, BCOP (1) · Jun Zhu, MD/PhD (1) · Nicolas Ketterer, MD (1) · Owen A O'Connor, MD, PhD (1) · Paul J. Martin, MD (1)
Results publications
PMID 26373676, PMID 19270260, PMID 27282998, PMID 30341058, PMID 30617197, PMID 30770362, PMID 31053601, PMID 32505213, PMID 33054054, PMID 33651099, PMID 33683917, PMID 34323957, PMID 34323958, PMID 34687398, PMID 35962459, PMID 37702406, PMID 38498084, PMID 38843483, PMID 39962481, PMID 42699559
NIH funding
2016 (1), P30CA069533 (1), U10CA032102 (1)