16 completed. 16 Phase 2, 4 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 16 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 1 | Completed 1 |
Follow Hereditary Angioedema: new trials by email Literature Review of Hereditary Angioedema trials Research Report on Hereditary Angioedema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Navenibart (STAR-0215) in Participants With Hereditary Angioedema Navenibart - Hereditary Angioedema | Phase 1 / Phase 2 | Completed | Astria Therapeutics, Inc. | 29 | 2023-02-21 | 2026-05-08 |
| Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema Deucrictibant, Placebo - Hereditary Angioedema, Hereditary Angioedema Type I | Phase 2 | Completed | Pharvaris Netherlands B.V. | 74 | 2021-02-03 | 2025-12-17 |
| An Extension Study of Donidalorsen (IONIS-PKK-LRx) in Participants With Hereditary Angioedema Donidalorsen - Hereditary Angioedema | Phase 2 | Completed | Ionis Pharmaceuticals, Inc. | 20 | 2020-03-31 | 2026-05-08 |
| A Study to Assess the Clinical Efficacy of Donidalorsen (Also Known as IONIS-PKK-LRx and ISIS 721744) in Participants With Hereditary Angioedema Donidalorsen, Placebo - Hereditary Angioedema | Phase 2 | Completed | Ionis Pharmaceuticals, Inc. | 23 | 2020-01-07 | 2023-04-03 |
| A Phase II, Cross-over Clinical Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) in the On-demand Treatment of Angioedema Attacks in Adult Subjects With Hereditary Angioedema Type I or II KVD900, Placebo - Hereditary Angioedema | Phase 2 | Completed | KalVista Pharmaceuticals, Ltd. | 84 | 2019-07-02 | 2025-05-02 |
| A Study to Investigate CSL312 in Subjects With Hereditary Angioedema (HAE) Factor XIIa antagonist monoclonal antibody, Placebo - Hereditary Angioedema | Phase 2 | Completed | CSL Behring | 44 | 2018-10-29 | 2022-11-08 |
| A Long Term Safety Study of BCX7353 in Hereditary Angioedema BCX7353 - Hereditary Angioedema, HAE | Phase 2 / Phase 3 | Completed | BioCryst Pharmaceuticals | 387 | 2018-02-16 | 2023-06-18 |
| 12-Week Safety and Efficacy Study of BCX4161 as an Oral Prophylaxis Against HAE Attacks BCX4161, Placebo - Hereditary Angioedema, HAE | Phase 2 / Phase 3 | Completed | BioCryst Pharmaceuticals | 110 | 2014-12-17 | 2025-11-17 |
| A Phase 2 HAE Prophylaxis Study With Recombinant Human C1 Inhibitor Recombinant human C1 inhibitor, Placebo - Hereditary Angioedema | Phase 2 | Completed | Pharming Technologies B.V. | 32 | 2014-12-01 | 2017-12-08 |
| Safety and Efficacy of Oral BCX4161 as a Prophylactic Treatment for HAE BCX4161, Placebo - Hereditary Angioedema | Phase 2 | Completed | BioCryst Pharmaceuticals | 24 | 2013-11-01 | 2014-08-18 |
| Safety of Ruconest in 2-13 Year Old Hereditary Angioedema (HAE) Patients rhC1INH - Hereditary Angioedema | Phase 2 | Completed | Pharming Technologies B.V. | 57 | 2012-01-17 | 2024-03-29 |
| A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase CINRYZE with rHuPH20 - Hereditary Angioedema | Phase 2 | Completed | Shire | 12 | 2011-09-12 | 2021-07-19 |
| A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CINRYZE Administration CINRYZE - Hereditary Angioedema | Phase 2 | Completed | Shire | 26 | 2010-06-07 | 2021-07-09 |
| A Study of the Safety and Immunogenicity of Repeated rhC1INH Administration Recombinant Human C1 Inhibitor - Genetic Disorders, Hereditary Angioedema | Phase 2 | Completed | Pharming Technologies B.V. | 25 | 2009-06-01 | 2018-06-26 |
| Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema Recombinant Human C1 Inhibitor, placebo - Hereditary Angioedema, Angioneurotic Edema | Phase 2 / Phase 3 | Completed | Pharming Technologies B.V. | 77 | 2005-07-01 | 2013-02-22 |
| Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) Attacks C1 Esterase Inhibitor, Placebo - Hereditary Angioedema | Phase 2 / Phase 3 | Completed | CSL Behring | 126 | 2005-06-01 | 2015-03-31 |
Angioedemas, Hereditary (16) · Angioedema (3) · Genetic Diseases, Inborn (1) · Hereditary Angioedema Types I and II (1)
Cardiovascular Diseases (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (16) · Hereditary Complement Deficiency Diseases (16) · Hypersensitivity (16) · Hypersensitivity, Immediate (16) · Immune System Diseases (16) · Immunologic Deficiency Syndromes (16) · Primary Immunodeficiency Diseases (16) · Skin Diseases (16) · Skin Diseases, Vascular (16) · Skin and Connective Tissue Diseases (16) · Urticaria (16) · Vascular Diseases (16) · Genetic Diseases, Inborn (15) · Angioedema (13)
Complement C1 Inhibitor Protein (5) · conestat alfa (4) · IONIS-PKK-LRx (2) · SERPING1 protein, human (2) · Sodium Chloride (2) · avoralstat (2) · donidalorsen (2) · berotralstat (1) · sebetralstat (1)
Pharming Technologies B.V. (4) · BioCryst Pharmaceuticals (3) · CSL Behring (2) · Ionis Pharmaceuticals, Inc. (2) · Shire (2) · Astria Therapeutics, Inc. (1) · KalVista Pharmaceuticals, Ltd. (1) · Pharvaris Netherlands B.V. (1)
United States (13) · Germany (8) · United Kingdom (7) · Canada (6) · Czechia (6) · Hungary (6) · Italy (6) · Netherlands (6) · Israel (5) · North Macedonia (5) · Poland (5) · Romania (4) · Australia (3) · Bulgaria (3) · France (3)
Anurag Relan, MD (2) · Bruno Giannetti, MD (1) · Henriette Farkas, MD (1) · Marc Riedl, MD MS (1) · Marcus Maurer, MD (1) · Marcus Maurer, Prof MD (1)
PMID 36326435, PMID 19767078, PMID 20674826, PMID 20920772, PMID 23535096, PMID 23987198, PMID 28284978, PMID 28754491, PMID 30993784, PMID 34161665, PMID 35219377, PMID 35294812, PMID 35820771, PMID 36408587, PMID 36774155, PMID 38006972, PMID 38009241, PMID 38020288, PMID 38710185, PMID 40490218, PMID 41794053, PMID 41802598, PMID 41865747, PMID 42159953, PMID 42268494, PMID 42318595
2004 (1), 2018 (1), 2019 (1)