2 completed, 1 active not recruiting. 3 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 2, Active not recruiting 1 |
| Phase 3 | 2 | Completed 2 |
| Phase 1 | 1 | Active not recruiting 1 |
Follow HAE: new trials by email Literature Review of HAE trials Research Report on HAE
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema Dose 1 of BMN 331, Dose 2 of BMN 331, Dose 3 of BMN 331 - Hereditary Angioedema, HAE | Phase 1 / Phase 2 | Active not recruiting | BioMarin Pharmaceutical | 44 | 2022-02-15 | 2024-05-16 |
| A Long Term Safety Study of BCX7353 in Hereditary Angioedema BCX7353 - Hereditary Angioedema, HAE | Phase 2 / Phase 3 | Completed | BioCryst Pharmaceuticals | 387 | 2018-02-16 | 2023-06-18 |
| 12-Week Safety and Efficacy Study of BCX4161 as an Oral Prophylaxis Against HAE Attacks BCX4161, Placebo - Hereditary Angioedema, HAE | Phase 2 / Phase 3 | Completed | BioCryst Pharmaceuticals | 110 | 2014-12-17 | 2025-11-17 |
Angioedema (3) · Cardiovascular Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Hereditary Complement Deficiency Diseases (3) · Hypersensitivity (3) · Hypersensitivity, Immediate (3) · Immune System Diseases (3) · Immunologic Deficiency Syndromes (3) · Primary Immunodeficiency Diseases (3) · Skin Diseases (3) · Skin Diseases, Vascular (3) · Skin and Connective Tissue Diseases (3) · Urticaria (3) · Vascular Diseases (3)
avoralstat (1) · berotralstat (1)
BioCryst Pharmaceuticals (2) · BioMarin Pharmaceutical (1)
United States (3) · Australia (2) · France (2) · Germany (2) · Hungary (2) · Italy (2) · Spain (2) · United Kingdom (2) · Austria (1) · Belgium (1) · Canada (1) · Denmark (1) · Hong Kong (1) · Israel (1) · New Zealand (1)
Henriette Farkas, MD (1) · Marc Riedl, MD MS (1)
PMID 34161665, PMID 35820771, PMID 36326435, PMID 36408587, PMID 38006972, PMID 38020288, PMID 40490218