9 completed, 2 terminated. 11 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 9, Terminated 2 |
| Phase 2 | 2 | Completed 2 |
Follow Childhood Diffuse Large Cell Lymphoma: new trials by email Literature Review of Childhood Diffuse Large Cell Lymphoma trials Research Report on Childhood Diffuse Large Cell Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Morphotek | 27 | 2013-11-01 | 2016-01-08 |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
| Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia dexrazoxane hydrochloride, doxorubicin hydrochloride, obatoclax mesylate - Acute Leukemias of Ambiguous Lineage, Acute Undifferentiated Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 22 | 2009-06-01 | 2014-05-01 |
| Bevacizumab and Cediranib Maleate in Treating Patients With Metastatic or Unresectable Solid Tumor, Lymphoma, Intracranial Glioblastoma, Gliosarcoma or Anaplastic Astrocytoma bevacizumab, cediranib maleate - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 57 | 2007-05-01 | 2014-02-19 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia vorinostat, isotretinoin - Childhood Acute Promyelocytic Leukemia (M3), Childhood Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 60 | 2005-08-01 | 2014-06-17 |
| Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas irinotecan hydrochloride, oxaliplatin - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2005-03-01 | 2013-06-05 |
| Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma oxaliplatin, etoposide - Angioimmunoblastic T-cell Lymphoma, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 40 | 2004-11-01 | 2014-02-24 |
| Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2003-09-01 | 2020-01-18 |
| Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer total-body irradiation, fludarabine phosphate, cyclosporine - Acute Undifferentiated Leukemia, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 21 | 2000-05-01 | 2020-01-21 |
Burkitt Lymphoma (11) · Dendritic Cell Sarcoma, Interdigitating (11) · Lymphoma, Large B-Cell, Diffuse (11) · Recurrence (10) · Lymphoma, Extranodal NK-T-Cell (9) · Lymphoma, Large-Cell, Anaplastic (9) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (9) · Leukemia, Hairy Cell (7) · Leukemia, Lymphocytic, Chronic, B-Cell (7) · Mycosis Fungoides (7) · Sezary Syndrome (7) · Immunoblastic Lymphadenopathy (6) · Intraocular Lymphoma (6) · Leukemia, Large Granular Lymphocytic (6) · Lymphoma, B-Cell, Marginal Zone (6)
DNA Virus Infections (11) · Disease Attributes (11) · Epstein-Barr Virus Infections (11) · Hemic and Lymphatic Diseases (11) · Herpesviridae Infections (11) · Histiocytic Disorders, Malignant (11) · Histiocytosis (11) · Immune System Diseases (11) · Immunoproliferative Disorders (11) · Infections (11) · Lymphatic Diseases (11) · Lymphoma (11) · Lymphoma, B-Cell (11) · Lymphoproliferative Disorders (11) · Neoplasms (11)
Cyclosporine (3) · Mycophenolic Acid (3) · fludarabine phosphate (3) · Oxaliplatin (2) · Peripheral Blood Stem Cell Transplantation (2) · Vorinostat (2) · Whole-Body Irradiation (2) · Bevacizumab (1) · Biopsy (1) · Bortezomib (1) · Cyclophosphamide (1) · Dexrazoxane (1) · Doxorubicin (1) · Etoposide (1) · Immunologic Techniques (1)
National Cancer Institute (NCI) (7) · Fred Hutchinson Cancer Center (3) · Morphotek (1)
United States (11) · Canada (2) · Italy (2) · Germany (1)
Lisa McGregor (2) · Maryam Fouladi (2) · Brenda Sandmaier (1) · Colleen Delaney (1) · David Hong (1) · David Maloney (1) · Jodi Muscal (1) · Richard Aplenc (1) · Robin Norris (1)
PMID 32499241, PMID 23393050, PMID 29292843
U01CA097452 (5), P30CA015704 (2), P01CA018029 (1), P01CA078902 (1), P30CA016672 (1), P30CA021765 (1), R24HL074445 (1), R43HL106868 (1), RC2HL101844 (1), U01CA062461 (1)