3 completed, 2 active not recruiting, 2 terminated, 1 withdrawn. 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 3, Active not recruiting 2, Terminated 2, Withdrawn 1 |
Follow BRCA1 Gene Mutation: new trials by email Literature Review of BRCA1 Gene Mutation trials Research Report on BRCA1 Gene Mutation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Niraparib, Abiraterone Acetate and Prednisone for mHSPC With Deleterious Homologous Recombination Repair Alterations Androgen Deprivation Therapy (ADT), Niraparib/Abiraterone Acetate DAT, Abiraterone Acetate - Metastatic Hormone-sensitive Prostate Cancer (mHSPC), Deleterious HRR Gene Mutation | Phase 2 | Withdrawn | Qian Qin | 2025-10-01 | 2026-04-08 | |
| Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects Niraparib, Niraparib Tosylate Monohydrate, Radical Prostatectomy - ATM Gene Mutation, BRCA1 Gene Mutation | Phase 2 | Terminated | University of California, Davis | 11 | 2020-02-25 | 2026-05-14 |
| Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency Carboplatin, Docetaxel, Laboratory Biomarker Analysis - ATM Gene Mutation, BRCA1 Gene Mutation | Phase 2 | Terminated | University of Washington | 18 | 2018-08-24 | 2026-08-26 |
| Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability Laboratory Biomarker Analysis, Pembrolizumab - BRCA1 Gene Mutation, BRCA2 Gene Mutation | Phase 2 | Active not recruiting | Rutgers, The State University of New Jersey | 21 | 2018-03-08 | 2026-04-03 |
| Olaparib, Durvalumab, and Tremelimumab in Treating Patients With Recurrent or Refractory Ovarian, Fallopian Tube or Primary Peritoneal Cancer With BRCA1 or BRCA2 Mutation Durvalumab, Laboratory Biomarker Analysis, Olaparib - BRCA1 Gene Mutation, BRCA2 Gene Mutation | Phase 2 | Completed | Roswell Park Cancer Institute | 40 | 2017-06-29 | 2024-11-19 |
| Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer Laboratory Biomarker Analysis, Pharmacological Study, Talazoparib - ATM Gene Mutation, ATR Gene Mutation | Phase 2 | Completed | SWOG Cancer Research Network | 51 | 2017-03-03 | 2021-06-23 |
| Talazoparib in Treating Patients With Recurrent, Refractory, Advanced, or Metastatic Cancers and Alterations in the BRCA Genes Laboratory Biomarker Analysis, Pharmacological Study, Talazoparib - Advanced Malignant Neoplasm, ATM Gene Mutation | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 150 | 2014-12-22 | 2026-06-12 |
| ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer ABT-888, temozolomide - Breast Cancer, Metastatic Breast Cancer | Phase 2 | Completed | Steven J Isakoff, MD, PhD | 63 | 2009-11-01 | 2025-03-14 |
Breast Neoplasms (2) · Neoplasm Metastasis (2) · Ovarian Neoplasms (2) · Fallopian Tube Neoplasms (1) · Neoplasms (1) · Prostatic Neoplasms (1) · Recurrence (1)
Neoplasms (4) · Neoplasms by Site (4) · Genital Diseases (3) · Urogenital Diseases (3) · Urogenital Neoplasms (3) · Adnexal Diseases (2) · Breast Diseases (2) · Endocrine Gland Neoplasms (2) · Endocrine System Diseases (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Genital Diseases, Female (2) · Genital Neoplasms, Female (2) · Gonadal Disorders (2) · Neoplastic Processes (2)
Docetaxel (2) · niraparib (2) · talazoparib (2) · Abiraterone Acetate (1) · Androgen Antagonists (1) · Carboplatin (1) · Disulfides (1) · Immunoglobulin G (1) · Prednisone (1) · Temozolomide (1) · durvalumab (1) · olaparib (1) · pembrolizumab (1) · rucaparib (1) · tremelimumab (1)
M.D. Anderson Cancer Center (1) · Qian Qin (1) · Roswell Park Cancer Institute (1) · Rutgers, The State University of New Jersey (1) · SWOG Cancer Research Network (1) · Steven J Isakoff, MD, PhD (1) · University of California, Davis (1) · University of Washington (1)
United States (7) · Canada (1)
Emese Zsiros (1) · Eugenia Girda, MD (1) · Heather H. Cheng (1) · Marc Dall'Era (1) · Qian Qin, MD (1) · Sarina A Piha-Paul (1) · Steven Isakoff, MD, PhD (1) · Vassiliki Papadimitrakopoulou (1)
P30CA072720 (1), P30CA093373 (1), U10CA180888 (1)