B-Cell Chronic Lymphocytic Leukemia: Clinical Trials

4 completed. 4 Phase 3.

By phase and status

Phase	Trials	Status
Phase 3	4	Completed 4

Follow B-Cell Chronic Lymphocytic Leukemia: new trials by email Literature Review of B-Cell Chronic Lymphocytic Leukemia trials Research Report on B-Cell Chronic Lymphocytic Leukemia

Trials (filtered) newest first · largest first

All 4 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial) Lenalidomide, Chlorambucil - B-Cell Chronic Lymphocytic Leukemia	Phase 3	Completed	Celgene	450	2009-10-13	2019-07-09
A Study to Evaluate the Efficacy and Safety of Lenalidomide as Maintenance Therapy for Patients With B-Cell Chronic Lymphocytic Leukemia (CLL) Following Second Line Therapy Lenalidomide, Placebo - B-cell Chronic Lymphocytic Leukemia	Phase 3	Completed	Celgene	317	2009-01-27	2021-12-02
Fludarabine (Fludara®) Plus Alemtuzumab (CAMPATH®, MabCampath®) vs Fludarabine Alone in B-Cell Chronic Lymphocytic Leukemia (B-CLL) Patients FluCAM [Fludara + Campath], fludarabine phosphate - B-Cell Chronic Lymphocytic Leukemia	Phase 3	Completed	Genzyme, a Sanofi Company	335	2004-07-01	2014-03-13
Fludarabine, Cyclophosphamide, and Rituximab Versus Pentostatin, Cyclophosphamide, and Rituximab in Previously Untreated or Treated B-Cell Chronic Lymphocytic Leukemia Patients Fludarabine, Cyclophosphamide, Rituximab - B-Cell Chronic Lymphocytic Leukemia	Phase 3	Completed	US Oncology Research	184	2003-12-01	2016-11-03

Narrower conditions

Leukemia, Lymphocytic, Chronic, B-Cell (4)

Broader conditions

Chronic Disease (4)  ·  Disease Attributes (4)  ·  Hematologic Diseases (4)  ·  Hemic and Lymphatic Diseases (4)  ·  Immune System Diseases (4)  ·  Immunoproliferative Disorders (4)  ·  Leukemia (4)  ·  Leukemia, B-Cell (4)  ·  Leukemia, Lymphoid (4)  ·  Lymphatic Diseases (4)  ·  Lymphoproliferative Disorders (4)  ·  Neoplasms (4)  ·  Neoplasms by Histologic Type (4)  ·  Pathologic Processes (4)  ·  Pathological Conditions, Signs and Symptoms (4)

Interventions

Lenalidomide (2)  ·  Alemtuzumab (1)  ·  Chlorambucil (1)  ·  Cyclophosphamide (1)  ·  Pentostatin (1)  ·  Rituximab (1)  ·  fludarabine (1)  ·  fludarabine phosphate (1)

Sponsors

Celgene (2)  ·  Genzyme, a Sanofi Company (1)  ·  US Oncology Research (1)

Countries

United States (4)  ·  Austria (3)  ·  Canada (3)  ·  France (3)  ·  Italy (3)  ·  Poland (3)  ·  Portugal (3)  ·  Romania (3)  ·  Russia (3)  ·  Australia (2)  ·  Belgium (2)  ·  Bulgaria (2)  ·  Colombia (2)  ·  Croatia (2)  ·  Czechia (2)

Top investigators

Craig Reynolds, MD (1)  ·  Jeffrey Jones, MD (1)  ·  Richard Delarue, MD (1)

Results publications

PMID 21992852, PMID 28140392, PMID 28958469

NIH funding

2004 (1), 2008 (1)