12 completed. 12 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 12 |
| Phase 2 | 1 | Completed 1 |
Follow Avian Influenza: new trials by email Literature Review of Avian Influenza trials Research Report on Avian Influenza
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety and Immunogenicity of Two Doses of a Novel H5 Central Antigen mRNA-LNP in Healthy Adults H5 AC-Anhui RNA Vaccine, H5 Astrakhan RNA Vaccine, Sodium Chloride, 0.9% - Avian Influenza | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 80 | 2025-06-12 | 2026-06-12 |
| H5N1 With or Without Topical Aldara in Healthy Adults Aqueous Cream B.P., Imiquimod, Influenza Virus Vaccine, Monovalent A/H5N1 A/Vietnam/1203/04 - Avian Influenza, Influenza Immunisation | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 50 | 2018-06-13 | 2020-02-24 |
| H5N8 Mix and Match With or Without AS03 or MF59 in Healthy Adults: Immunology AS03, MF59, Monovalent Influenza A/H5N8 vaccine - Avian Influenza | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 388 | 2017-01-09 | 2024-09-23 |
| H5N8 Mix and Match With or Without AS03 or MF59 in Healthy Adults AS03, MF59 adjuvant, Monovalent Influenza A/H5N8 vaccine - Avian Influenza, Influenza | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 276 | 2016-08-16 | 2019-10-23 |
| A Phase I Study Priming With an Inactivated A/H7N9 Influenza Virus Vaccine With or Without MF59 Adjuvant Followed by Live Attenuated A/H7N9 Influenza Virus Vaccine Influenza Virus Vaccine, Live Attenuated H7N9 Anhui 2013/AA ca, Influenza Virus Vaccine, Monovalent A/H7N9 A/Shanghai/2/2013, MF59 adjuvant - Avian Influenza, Immunisation | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 62 | 2015-05-18 | 2020-01-27 |
| A(H7N9) VLP Antigen Dose Ranging Study With Adjuvant 1 Monovalent Avian Influenza VLP (H7N9), Adjuvant 1, Placebo - Avian Influenza | Phase 1 | Completed | Novavax | 280 | 2013-07-01 | 2014-10-13 |
| Safety and Pharmacokinetics Study of FBF001 FBF001, Placebo - Avian Influenza | Phase 1 | Completed | Fab'entech | 16 | 2012-10-01 | 2014-11-20 |
| Immunogenicity of ND1.1 by Delivery Directly to the Ileum ND1.1 - Avian Influenza | Phase 1 | Completed | Vaxart | 12 | 2012-09-01 | 2014-12-10 |
| A Phase I Study to Evaluate the Safety, Reactogenicity, and Humoral Immune Responses to an Inactivated H5N1 Influenza Vaccine AT-301 - Bird Flu, Avian Influenza | Phase 1 | Completed | Medigen Biotechnology Corporation | 36 | 2012-08-01 | 2013-10-25 |
| Safety Trial of Live Attenuated Influenza (H7N3) Vaccine LAIV H7N3, placebo - Influenza, Avian Influenza | Phase 1 | Completed | PATH | 40 | 2012-04-01 | 2019-04-22 |
| Safety Study of an Oral Vaccine to Prevent Avian Influenza ND1.1, Placebo control - Avian Influenza, Bird Flu | Phase 1 | Completed | Vaxart | 54 | 2011-04-01 | 2013-01-03 |
| Immunogenicity and Safety Study of a Single Prime-Boost Vaccination Schedule With a H5N1 Influenza Vaccine in Adults Influenza vaccine (whole virion, Vero cell derived) - Influenza, Avian Influenza | Phase 1 / Phase 2 | Completed | Alachua Government Services, Inc. | 231 | 2009-05-01 | 2015-10-09 |
Influenza in Birds (12) · Influenza, Human (7)
Animal Diseases (12) · Bird Diseases (12) · Infections (12) · Orthomyxoviridae Infections (12) · RNA Virus Infections (12) · Virus Diseases (12) · Respiratory Tract Diseases (7) · Respiratory Tract Infections (7)
Influenza Vaccines (3) · Sodium Chloride (2) · Imiquimod (1) · MF59 oil emulsion (1)
National Institute of Allergy and Infectious Diseases (NIAID) (5) · Vaxart (2) · Alachua Government Services, Inc. (1) · Fab'entech (1) · Medigen Biotechnology Corporation (1) · Novavax (1) · PATH (1)
United States (7) · Australia (1) · Austria (1) · Finland (1) · Russia (1) · Taiwan (1)
D. Nigel Thomas, Ph.D. (1) · David Liebowitz, MD, PhD (1) · Gerald Aichinger, MD (1) · Igor Victorevich (1) · Kathleen M Neuzil, MD, MPH (1) · Larisa G Rudenko, MD, PhD, DSc (1) · Martin Kabongo, MD, PhD (1) · Oleg I Kiselev, MD, PhD, DSc (1) · Pan-Chyr Yang, MD, PhD (1) · Sean N Tucker, PhD (1)
PMID 23357198, PMID 24224560, PMID 24533064, PMID 25662592, PMID 26432909, PMID 31255574, PMID 33852718