10 completed, 1 terminated, 1 unknown. 5 Phase 2, 4 Phase 1, 3 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Terminated 1, Unknown 1 |
| Phase 1 | 4 | Completed 4 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Phase 4 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety Study of PEG-rIL-29 Plus Ribavirin to Treat Chronic Hepatitis C Virus Infection PEG-rIL-29, Peginterferon alfa-2a, Ribavirin - Hepatitis C, Chronic | Phase 2 | Unknown | ZymoGenetics | 600 | 2010-05-01 | 2011-12-05 |
| Safety and Immunogenicity Study of Recombinant Thrombin (rThrombin) in Pediatric Participants rThrombin, 1000 IU/mL - Blood Loss, Surgical | Phase 4 | Completed | ZymoGenetics | 30 | 2009-03-01 | 2012-01-26 |
| Immunogenicity and Safety Study of rThrombin in Surgical Hemostasis rThrombin, 1000 IU/mL - Blood Loss, Surgical | Phase 4 | Completed | ZymoGenetics | 31 | 2009-01-01 | 2011-12-08 |
| Interleukin-21 in Treating Patients With Metastatic or Recurrent Malignant Melanoma recombinant human interleukin-21, immunohistochemistry staining method, laboratory biomarker analysis - Melanoma (Skin) | Phase 2 | Completed | NCIC Clinical Trials Group | 40 | 2007-12-13 | 2023-08-04 |
| The Efficacy and Safety of Atacicept in Combination With Mycophenolate Mofetil Used to Treat Lupus Nephritis Atacicept, Mycophenolate mofetil, Placebo - Lupus Nephritis | Phase 2 / Phase 3 | Terminated | EMD Serono | 6 | 2007-12-01 | 2016-03-23 |
| Study of PEG-rIL-29 (or PEG-IFN Lambda) in Subjects With Chronic Hepatitis C Virus Infection PEGylated recombinant interleukin 29 (PEG-rIL-29) - Hepatitis C, Chronic | Phase 1 | Completed | ZymoGenetics | 56 | 2007-12-01 | 2009-10-07 |
| Immunogenicity and Safety Study of Topical Recombinant Thrombin in Surgical Hemostasis rThrombin - Spinal Surgery, Vascular Surgery | Phase 3 | Completed | ZymoGenetics | 234 | 2007-06-01 | 2012-01-13 |
| Study of Recombinant Interleukin 21 in Combination With Sorafenib for Metastatic Renal Cell Carcinoma rIL-21 only, rIL-21 + sorafenib - Carcinoma, Renal Cell | Phase 1 / Phase 2 | Completed | ZymoGenetics | 52 | 2006-10-01 | 2009-05-27 |
| Study of Recombinant Human Thrombin for Bleeding During Autologous Skin Grafting rThrombin - Surgical Hemostasis | Phase 2 | Completed | ZymoGenetics | 72 | 2006-08-01 | 2009-03-09 |
| Study of Recombinant Interleukin 21 in Combination With Rituxan for Non-Hodgkin's Lymphoma recombinant human interleukin 21 and rituximab - Lymphoma, Non-Hodgkin | Phase 1 | Completed | ZymoGenetics | 23 | 2006-06-01 | 2008-09-05 |
| Study of Recombinant Human Thrombin for Bleeding During Surgery rThrombin, bovine thrombin - Surgical Hemostasis | Phase 3 | Completed | ZymoGenetics | 401 | 2005-10-01 | 2009-03-09 |
| Study of Interleukin-21 for Metastatic Malignant Melanoma and Metastatic Kidney Cancer Recombinant Human Interleukin-21 - Melanoma, Kidney Neoplasms | Phase 1 | Completed | ZymoGenetics | 43 | 2004-05-01 | 2009-03-09 |
Blood Loss, Surgical (2) · Carcinoma, Renal Cell (2) · Hepatitis C (2) · Hepatitis C, Chronic (2) · Infections (2) · Melanoma (2) · Virus Diseases (2) · Kidney Neoplasms (1) · Liver Diseases (1) · Lupus Nephritis (1) · Lymphoma, Non-Hodgkin (1) · Neoplasm Metastasis (1) · Nephritis (1)
recombinant human thrombin (5) · Thrombin (3) · peginterferon lambda-1a (2) · Adrenal Cortex Hormones (1) · Immunohistochemistry (1) · Mycophenolic Acid (1) · Ribavirin (1) · Rituximab (1) · Sorafenib (1) · TACI receptor-IgG Fc fragment fusion protein (1) · peginterferon alfa-2a (1)
United States (11) · Canada (3) · Australia (1) · Austria (1) · Czechia (1) · France (1) · Germany (1) · Italy (1) · Malaysia (1) · Poland (1) · Puerto Rico (1) · Romania (1) · Singapore (1) · Spain (1) · Taiwan (1)
Allan Alexander, MD (1) · Allan Alexander, MD, CPI (1) · Diana F Hausman, MD (1) · Diana Hausman, MD (1) · Fred Weaver, MD (1) · Jan Hillson, MD (1) · Kenneth Renkens, MD (1) · Kevin Foster, MD (1) · Muriel Siadak, PA-C (1) · Naomi Hunder, MD (1) · Neil Singla, MD (1) · Teresa M. Petrella (1) · Thomas C Reynolds, MD, PhD (1) · William Chapman, MD (1)
PMID 17660072, PMID 18440754, PMID 19651065, PMID 20980172, PMID 22008340, PMID 22325903, PMID 22915661, PMID 24829759, PMID 25042797, PMID 25043197, PMID 38837237
2009 (1)