7 completed, 1 terminated. 3 Phase 3, 3 Phase 4, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 3 | Completed 3 |
| Phase 4 | 3 | Completed 2, Terminated 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
Follow recombinant human thrombin: new trials by email Literature Review of recombinant human thrombin trials Research Report on recombinant human thrombin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin - Opioid Pain Medication | Phase 4 | Terminated | NYU Langone Health | 46 | 2021-03-24 | 2024-06-26 |
| Safety and Efficacy of Topical Recombinant Human Thrombin(rhThrombin) for Surgical Hemostasis recombinant human Thrombin(CHO cell), placebo - Surgical Hemostasis | Phase 3 | Completed | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 348 | 2019-11-11 | 2022-11-29 |
| Topical rhThrombin as an Adjunct to Hemostasis During Segmental Hepatectomy rhThrombin ( Topical ), placebo - Hepatectomy | Phase 1 / Phase 2 | Completed | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 84 | 2017-11-29 | 2021-04-14 |
| Safety and Immunogenicity Study of Recombinant Thrombin (rThrombin) in Pediatric Participants rThrombin, 1000 IU/mL - Blood Loss, Surgical | Phase 4 | Completed | ZymoGenetics | 30 | 2009-03-01 | 2012-01-26 |
| Immunogenicity and Safety Study of rThrombin in Surgical Hemostasis rThrombin, 1000 IU/mL - Blood Loss, Surgical | Phase 4 | Completed | ZymoGenetics | 31 | 2009-01-01 | 2011-12-08 |
| Immunogenicity and Safety Study of Topical Recombinant Thrombin in Surgical Hemostasis rThrombin - Spinal Surgery, Vascular Surgery | Phase 3 | Completed | ZymoGenetics | 234 | 2007-06-01 | 2012-01-13 |
| Study of Recombinant Human Thrombin for Bleeding During Autologous Skin Grafting rThrombin - Surgical Hemostasis | Phase 2 | Completed | ZymoGenetics | 72 | 2006-08-01 | 2009-03-09 |
| Study of Recombinant Human Thrombin for Bleeding During Surgery rThrombin, bovine thrombin - Surgical Hemostasis | Phase 3 | Completed | ZymoGenetics | 401 | 2005-10-01 | 2009-03-09 |
ZymoGenetics (5) · Suzhou Zelgen Biopharmaceuticals Co.,Ltd (2) · NYU Langone Health (1)
United States (6) · China (2)
Allan Alexander, MD (1) · Allan Alexander, MD, CPI (1) · David Chiu, MD (1) · Fred Weaver, MD (1) · Kenneth Renkens, MD (1) · Kevin Foster, MD (1) · Neil Singla, MD (1) · Sheng Yan, PhD (1) · Thomas C Reynolds, MD, PhD (1) · William Chapman, MD (1) · Zhiwei Li, PhD (1)
PMID 17660072, PMID 18440754, PMID 19651065, PMID 20980172, PMID 22008340, PMID 38837237