16 completed, 5 terminated. 16 Phase 2, 8 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 12, Terminated 4 |
| Phase 1 | 8 | Completed 8 |
| Phase 3 | 4 | Completed 3, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 2 Study of Telintra® in Deletion 5q Myelodysplastic Syndrome ezatiostat hydrochloride (Telintra®) - Myelodysplastic Syndrome (MDS) | Phase 2 | Terminated | Telik | 2 | 2011-10-01 | 2013-11-25 |
| Study of (Telintra®) in Non-Del(5q) Myelodysplastic Syndrome ezatiostat hydrochloride (Telintra®) - Myelodysplastic Syndrome (MDS) | Phase 2 | Terminated | Telik | 162 | 2011-10-01 | 2013-11-25 |
| Study of Canfosfamide in Refractory or Relapsed Mantle Cell, Diffuse Large B Cell Lymphoma and Multiple Myeloma Canfosfamide HCl for injection - Mantle Cell Lymphoma, B Cell Lymphoma | Phase 2 | Completed | Telik | 14 | 2010-06-01 | 2013-03-15 |
| Dose-Ranging Study of Telintra® Tablets + Revlimid® in Patients With Non-Deletion (5q) Low to Intermediate-1 Risk Myelodysplastic Syndrome (MDS) Ezatiostat Hydrochloride, Lenalidomide (Revlimid®) - Myelodysplastic Syndrome | Phase 1 | Completed | Telik | 19 | 2009-11-01 | 2013-06-06 |
| Study of Ezatiostat (Telintra Tablets) for Treatment of Severe Chronic Neutropenia Ezatiostat Hydrochloride - Severe Chronic Neutropenia | Phase 2 | Terminated | Telik | 9 | 2009-04-01 | 2013-11-25 |
| Study of Telintra for Treatment of Chemotherapy Induced Neutropenia in Patients With Non-Small Cell Lung Cancer ezatiostat hydrochloride (Telintra®) - Non-small Cell Lung Cancer | Phase 2 | Terminated | Telik | 1 | 2008-10-01 | 2013-11-27 |
| Phase 2 Study Comparing Two Dose Schedules of Telintra™ in Myelodysplastic Syndrome (MDS) Ezatiostat Hydrochloride - Myelodysplastic Syndrome (MDS) | Phase 2 | Completed | Telik | 86 | 2008-05-01 | 2011-10-12 |
| Phase 3 Randomized Study of Telcyta + Doxorubicin Versus Doxorubicin in Platinum Refractory or Resistant Ovarian Cancer Telcyta, Liposomal Doxorubicin - Ovarian Neoplasms | Phase 3 | Terminated | Telik | 244 | 2006-05-01 | 2013-11-27 |
| Study of TLK199 Tablets in Myelodysplastic Syndrome (MDS) Ezatiostat Hydrochlorine - Myelodysplastic Syndrome (MDS) | Phase 1 / Phase 2 | Completed | Telik | 49 | 2006-02-01 | 2012-05-31 |
| TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Doxil in Platinum Refractory or Resistant Ovarian Cancer TLK286 in Combination with Carboplatin, Doxorubicin HCl Liposome Injection - Ovarian Neoplasms | Phase 3 | Completed | Telik | 244 | 2004-12-01 | 2012-05-31 |
| Carboplatin, Paclitaxel and TLK286 (Telcyta) as First-Line Therapy in Advanced Non-Small Cell Lung Cancer TLK286, carboplatin, paclitaxel - Carcinoma, Non-Small-Cell Lung | Phase 1 / Phase 2 | Completed | Telik | 100 | 2004-08-01 | 2012-05-31 |
| TLK286 (Telcyta) in Combination With Cisplatin for Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) TLK286, cisplatin - Non-small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | Telik | 50 | 2004-02-01 | 2011-07-25 |
| TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer TLK286 HCl for injection, topotecan hydrochloride for injection, doxorubicin HCl liposome injection - Ovarian Neoplasms | Phase 3 | Completed | Telik | 440 | 2003-06-01 | 2011-07-25 |
| TLK286 in Combination With Doxil in Platinum Refractory or Resistant Ovarian Cancer TLK286 - Ovarian Neoplasms | Phase 1 / Phase 2 | Completed | Telik | 28 | 2003-02-01 | 2011-07-25 |
| TLK286 in Combination With Paraplatin (Carboplatin) in Recurrent Ovarian Cancer TLK286 - Ovarian Neoplasms | Phase 1 / Phase 2 | Completed | Telik | 28 | 2003-01-01 | 2011-07-25 |
| Phase 1-2a Dose-Ranging Study of TLK286 in Combination With Docetaxel in Platinum-Resistant Non-Small Cell Lung Cancer TLK286 in combination with docetaxel - Carcinoma, Non-small-cell Lung | Phase 1 / Phase 2 | Completed | Telik | 28 | 2002-10-01 | 2011-07-25 |
| Phase 2 Study of TLK286 Administered Weekly in Advanced Non-Small Cell Lung Cancer TLK286 - Carcinoma, Non-small-cell Lung | Phase 2 | Completed | Telik | 40 | 2002-07-01 | 2011-07-25 |
| Study of TLK199 HCl Liposomes for Injection in Myelodysplastic Syndrome TLK199 HCl Liposomes for Injection - Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Telik | 65 | 2002-04-01 | 2008-06-03 |
| Phase 2 Study of TLK286 in Metastatic Breast Cancer TLK286 - Breast Neoplasms | Phase 2 | Completed | Telik | 60 | 2002-04-01 | 2011-07-25 |
| Phase 2 Study of TLK286 in Platinum Resistant Advanced Epithelial Ovarian Cancer TLK286 - Ovarian Neoplasms | Phase 2 | Completed | Telik | 40 | 2001-06-01 | 2011-07-25 |
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Carcinoma, Non-Small-Cell Lung (6) · Myelodysplastic Syndromes (6) · Ovarian Neoplasms (6) · Breast Neoplasms (1) · Lymphoma (1) · Lymphoma, B-Cell (1) · Lymphoma, Mantle-Cell (1) · Lymphoma, Non-Hodgkin (1) · Multiple Myeloma (1) · Neutropenia (1) · Neutropenia, severe chronic (1)
TER 286 (12) · gamma-Glu-S-BzCys-PhGly diethyl ester (7) · Injections (4) · Carboplatin (2) · Cisplatin (1) · Docetaxel (1) · Gefitinib (1) · Lenalidomide (1) · Paclitaxel (1) · Topotecan (1) · liposomal doxorubicin (1)
United States (21) · Brazil (3) · United Kingdom (3) · Argentina (2) · Belgium (2) · Chile (2) · Germany (2) · Australia (1) · Czechia (1) · Hungary (1) · Ireland (1) · Italy (1) · Netherlands (1) · South Africa (1) · Spain (1)
Gail Brown, MD (4) · Gail L Brown, MD (2) · Gail Brown, M.D. (1) · Gail L. Brown, MD, MBA (1) · Joseph Bertino, MD (1)
PMID 37407274, PMID 19398716, PMID 19439093, PMID 20222977, PMID 20973267, PMID 22546242