27 completed, 13 terminated, 3 recruiting, 2 active not recruiting. 49 Phase 1, 19 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SBRT for Ultra-Central NonSmall Cell Lung Cancer SBRT - Nonsmall Cell Lung Cancer Stage | Phase 1 | Not yet recruiting | Georgetown University | 35 | 2026-11-01 | 2026-10-01 |
| Proglumide With Gemcitabine and Nab-Paclitaxel in PatientsWith Metastatic Pancreatic Ductal Adenocarcinoma Gemcitabine, Nab paclitaxel, Proglumide Dose level 1 - Metastatic Pancreatic Cancer | Phase 1 | Withdrawn | Georgetown University | 2023-10-01 | 2023-10-25 | |
| RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer TTP488, ddAC/ddT, TC - Cancer Related Cognitive Decline, Non-metastatic Breast Cancer | Phase 1 / Phase 2 | Recruiting | Georgetown University | 48 | 2023-06-06 | 2025-12-24 |
| Phase IB/II of CPX-351 for Relapse Prevention in AML CPX-351 - Acute Myeloid Leukemia (AML) in Remission | Phase 1 / Phase 2 | Recruiting | Georgetown University | 24 | 2023-05-22 | 2026-03-23 |
| Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) short burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) long burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training plus beta caryophyllene (CBOT-Plus) - Chronic Pain, Low Back Pain | Phase 1 | Completed | Evon Medics LLC | 86 | 2023-04-27 | 2024-01-23 |
| NEROFE and Doxorubicin in KRAS-mutated ST2-positive Solid Tumors NEROFE, Doxorubicin - Solid Tumor, KRAS Mutation-Related Tumors | Phase 1 | Recruiting | Georgetown University | 24 | 2023-04-12 | 2026-03-06 |
| Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis Proglumide, Placebo - Safety Issues, Pain | Phase 1 / Phase 2 | Active not recruiting | Georgetown University | 32 | 2022-11-17 | 2026-08-05 |
| Eryaspase With Modified FOLFIRINOX in Advanced Pancreatic Ductal Adenocarcinoma Eryaspase, FOLFIRINOX - Locally Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 | Completed | Georgetown University | 19 | 2020-12-02 | 2025-06-11 |
| Safety and Tolerability of Oral Proglumide for NASH Proglumide - Nonalcoholic Steatohepatitis | Phase 1 | Completed | Georgetown University | 18 | 2019-12-13 | 2022-10-13 |
| Study of Proton Therapy in Adjuvant Pancreatic Cancer mFOLFIRINOX, Proton beam radiation - Resected Pancreatic Adenocarcinoma | Phase 1 | Completed | Georgetown University | 9 | 2019-07-15 | 2024-10-24 |
| TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer Talazoparib, Avelumab - Breast Cancer | Phase 1 / Phase 2 | Active not recruiting | Georgetown University | 24 | 2019-04-19 | 2026-09-10 |
| WI231696: Bosutinib, Palbocicilib and Fulvestrant for HR+HER2- Advanced Breast Cancer Refractory to a CDK4/6 Inhibitor Palbociclib, Bosutinib, Fulvestrant - Metastatic Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast | Phase 1 | Completed | Georgetown University | 19 | 2019-04-01 | 2025-02-06 |
| Nilotinib in Huntington's Disease Nilotinib 150 MG - Huntington Disease | Phase 1 | Unknown | Georgetown University | 10 | 2018-11-15 | 2020-02-20 |
| Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma Durvalumab, CV301, Capecitabine - Metastatic Colorectal Cancer, Colorectal Adenocarcinoma | Phase 1 / Phase 2 | Terminated | Georgetown University | 8 | 2018-08-08 | 2024-02-05 |
| Nivolumab and 177Lu-DOTA0-Tyr3-Octreotate for Patients With Extensive-Stage Small Cell Lung Cancer Nivolumab, 177Lu-DOTA0-Tyr3-Octreotate - Small Cell Lung Cancer, Small Cell Lung Cancer Extensive Stage | Phase 1 / Phase 2 | Completed | Georgetown University | 9 | 2017-11-20 | 2021-03-16 |
| Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies Niraparib, Carboplatin - Solid Tumor, Adult, Homologous Recombination Deficiency | Phase 1 | Terminated | Georgetown University | 23 | 2017-10-13 | 2024-02-05 |
| LEE011 Plus Everolimus in Patients With Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy LEE011, Everolimus - Metastatic Pancreatic Adenocarcinoma | Phase 1 / Phase 2 | Completed | Georgetown University | 12 | 2017-05-04 | 2026-04-07 |
| Ibrutinib and Venetoclax in Relapsed and Refractory Follicular Lymphoma Ibrutinib, Venetoclax - Refractory Follicular Lymphoma, Relapsed Follicular Lymphoma | Phase 1 / Phase 2 | Completed | Georgetown University | 24 | 2017-03-01 | 2025-07-18 |
| CyberKnife Stereotactic Accelerated Partial Breast Irradiation (SAPBI) CK Stereotactic Accelerated Partial Breast Irradiation - Breast Cancer, DCIS | Phase 1 / Phase 2 | Terminated | Georgetown University | 2 | 2015-02-01 | 2018-04-13 |
| Phase I Study of Intravenous Artesunate for Solid Tumors Intravenous Artesunate - Solid Tumors | Phase 1 | Completed | Georgetown University | 19 | 2015-01-01 | 2016-11-18 |
Showing 20 of 49. Sign in to see all of them.
Colorectal Neoplasms (5) · Breast Neoplasms (4) · Neoplasms (4) · Pancreatic Neoplasms (4) · Lymphoma (3) · Head and Neck Neoplasms (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Multiple Myeloma (2) · Pain (2) · Parkinson Disease (2) · Recurrence (2) · Small Cell Lung Carcinoma (2) · Acquired Immunodeficiency Syndrome (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Carcinoma, Ovarian Epithelial (1)
Fluorouracil (3) · Oxaliplatin (3) · nilotinib (3) · Bortezomib (2) · Capecitabine (2) · Carboplatin (2) · Cetuximab (2) · Doxorubicin (2) · Gemcitabine (2) · Irinotecan (2) · LErafAON (2) · Lapatinib (2) · Lenalidomide (2) · Proglumide (2) · Rituximab (2)
United States (49)
Michael Pishvaian, MD PhD (6) · Claudine Isaacs, MD (4) · Benjamin Weinberg, MD (3) · Chaitra Ujjani, MD (2) · Jill P Smith, MD (2) · Anatoly Dritschilo, M.D. (1) · Ann W Gramza, MD (1) · Benjamin WE, MD (1) · Bruce D Cheson, MD (1) · Candace Mainor, MD (1) · Charles Nwaokobia (1) · Charles Rudin, M.D. (1) · Chul Kim, MD (1) · Daniel J Merenstein, MD (1) · David Deaton, MD (1)
PMID 24567288, PMID 25118794, PMID 27215559, PMID 27434297, PMID 28114246, PMID 29320335, PMID 29392450, PMID 29594044, PMID 29610115, PMID 31538230, PMID 31598921, PMID 32616557, PMID 37717786, PMID 38695613, PMID 38794273, PMID 40680102
P30CA051008 (3), R01CA121023 (1), R21CA163100 (1), R44NS125745 (1)