4 completed, 4 unknown. 6 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 4, Unknown 2 |
| Phase 2 | 4 | Unknown 4 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1-2 Study of Onapristone in Patients With Advanced Castration-resistant Prostate Cancer onapristone, abiraterone - Prostate Cancer, Metastatic Prostate Cancer | Phase 1 / Phase 2 | Unknown | Arno Therapeutics | 75 | 2014-02-01 | 2015-06-24 |
| Phase 1-2 Study of Onapristone in Patients With Progesterone Receptor Expressing Cancers onapristone - Progesterone Receptor Positive Tumor: Max 1 Line of Prior Chemotherapy, no Prior Hormone Therapy | Phase 1 / Phase 2 | Unknown | Arno Therapeutics | 60 | 2014-01-01 | 2015-06-24 |
| A Phase I Study of AR-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin) Given on Days 1, 4 8, 12 & 15 of an Every 21-day Cycle in Adult Patients With Refractory or Metastatic Solid Malignancies 7-t-butyldimethylsilyl-10-hydroxycamptothecin - Solid Malignancies | Phase 1 | Completed | University of Kentucky | 3 | 2010-09-01 | 2013-08-14 |
| AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphoma Pharmacodynamic Studies, Fatigue Inventory, Pharmacogenomic studies - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Amir Mortazavi | 44 | 2010-05-04 | 2018-06-04 |
| Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma AR-67 (7-t-butyldimethylsiltyl-10-hydroxy-camptothecin) - Glioblastoma Multiforme, GBM | Phase 2 | Unknown | Arno Therapeutics | 58 | 2009-12-01 | 2014-12-09 |
| Study of AR-12 (2-Amino-N-[4-[5-(2 Phenanthrenyl)-3-(Trifluoromethyl)-1H-pyrazol-1-yl] Phenyl]-Acetamide) in Adult Patients With Advanced or Recurrent Solid Tumors or Lymphoma AR-12: (2-Amino-N-[4-[5-(2 phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] phenyl]-acetamide) - Solid Tumors, Lymphoma | Phase 1 | Completed | Arno Therapeutics | 35 | 2009-08-01 | 2014-01-29 |
| Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS) AR-67 (20S)-7-t-Butyldimethylsilyl-10-hydroxycamptothecin) - Myelodysplastic Syndrome | Phase 2 | Unknown | Arno Therapeutics | 25 | 2009-06-01 | 2014-06-24 |
| Study of AR-67 (Formerly DB-67) in Adult Patients With Refractory or Metastatic Solid Malignancies AR-67 (formerly DB-67) - Tumors | Phase 1 | Completed | Arno Therapeutics | 26 | 2006-10-01 | 2009-08-11 |
Neoplasms (3) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Endometrial Neoplasms (1) · Genital Diseases, Male (1) · Genital Neoplasms, Male (1) · Glioblastoma (1) · Gliosarcoma (1) · Hodgkin Disease (1) · Immunoblastic Lymphadenopathy (1) · Intraocular Lymphoma (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Prolymphocytic (1) · Lymphoma (1) · Lymphoma, B-Cell, Marginal Zone (1)
7-tert-butyldimethylsilyl-10-hydroxycamptothecin (4) · onapristone (2) · Abiraterone Acetate (1) · OSU 03012 (1) · Pharmacogenomic Testing (1) · abiraterone (1)
United States (6) · United Kingdom (2) · Canada (1) · France (1)
Amir Mortazavi, MD (1) · James J Vredneburgh, MD (1) · James P Thomas, MD PhD (1) · Johann S de Bono, MD PhD (1) · Jorge Cortes, MD (1) · Paul H Cottu, MD (1) · Raoul Tibes, MD PhD (1) · Susanne Arnold, MD (1) · Susanne M Arnold, MD (1)
PMID 26943915, PMID 28270022, PMID 30304013, PMID 33492438
P30CA016058 (1)