4 completed, 3 terminated, 1 withdrawn. 4 Phase 2, 4 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 4 | Terminated 2, Completed 1, Withdrawn 1 |
| Phase 1 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nomacopan Therapy in Adult Patients With Bullous Pemphigoid Receiving Adjunct Oral Corticosteroid Therapy (ARREST-BP) nomacopan (rVA576), Placebo - Bullous Pemphigoid | Phase 3 | Withdrawn | AKARI Therapeutics | 2022-05-06 | 2025-04-09 | |
| Nomacopan (rVA576) in Transplant Associated Thrombotic Microangiopathy nomacopan (rVA576) - Thrombotic Microangiopathies | Phase 3 | Terminated | AKARI Therapeutics | 10 | 2021-02-01 | 2025-06-05 |
| Topical rVA576 for Treatment of Atopic Keratoconjunctivitis rVA576, Placebo - Keratoconjunctivitis, Atopic, Keratoconjunctivitis, Vernal | Phase 1 / Phase 2 | Terminated | AKARI Therapeutics | 12 | 2019-03-04 | 2025-04-10 |
| rVA576 in Adult Mild to Moderate Bullous Pemphigoid Subjects rVA576 - Bullous Pemphigoid (BP) | Phase 2 | Completed | AKARI Therapeutics | 9 | 2018-09-25 | 2025-04-22 |
| Treating Paroxysmal Nocturnal Haemoglobinuria Patients With rVA576 rVA576, Standard of care (SOC) - Paroxysmal Nocturnal Hemoglobinuria (PNH) | Phase 3 | Completed | AKARI Therapeutics | 9 | 2018-06-07 | 2025-04-09 |
| Coversin in PNH in Patients With Resistance to Eculizumab Due to Complement C5 Polymorphisms Coversin - Paroxysmal Nocturnal Hemoglobinuria (PNH) | Phase 2 | Completed | AKARI Therapeutics | 1 | 2018-05-14 | 2025-05-04 |
| rVA576 (Coversin) Long Term Safety and Efficacy Surveillance Study rVA576 - Paroxysmal Nocturnal Hemoglobinuria | Phase 3 | Terminated | AKARI Therapeutics | 15 | 2017-03-13 | 2025-04-10 |
| Coversin in Paroxysmal Nocturnal Haemoglobinuria (PNH) Coversin - Paroxysmal Nocturnal Haemoglobinuria (PNH) | Phase 2 | Completed | AKARI Therapeutics | 1 | 2016-02-01 | 2023-07-12 |
Hemoglobinuria, Paroxysmal (4) · Pemphigoid, Bullous (2) · Conjunctivitis, Allergic (1) · Keratoconjunctivitis (1) · Thrombotic Microangiopathies (1)
Standard of Care (1) · rEV576 protein, tick (1)
Netherlands (3) · Poland (3) · United States (3) · Germany (2) · United Kingdom (2) · Kazakhstan (1) · Lithuania (1) · Spain (1) · Sri Lanka (1)
Andrius Degulys, MBBS (1) · Petra Dr Muus (1) · Sajjad Ahmad (1) · Saskia Dr Langemeijer (1) · Wynne Weston Davies (1)