2 active not recruiting, 2 recruiting, 1 completed, 1 not yet recruiting. 4 Phase 3, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Active not recruiting 2, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow zigakibart: new trials by email Literature Review of zigakibart trials Research Report on zigakibart
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of the Efficacy and Safety of Zigakibart + Atrasentan in Adult Patients With Primary IgA Nephropathy zigakibart, atrasentan, Placebo - IgA Nephropathy (IgAN) | Phase 3 | Not yet recruiting | Novartis Pharmaceuticals | 340 | 2026-12-01 | 2026-09-30 |
| A Study to Assess the Effects of Zigakibart on IgA Nephropathy. zigakibart - Immunoglobulin A Nephropathy (IgAN) | Phase 2 | Recruiting | Novartis Pharmaceuticals | 32 | 2026-03-26 | 2026-10-21 |
| Open-label Extension Study of Zigakibart in Adults With IgA Nephropathy. zigakibart - Kidney Diseases, Kidney Diseases, Chronic | Phase 3 | Recruiting | Novartis Pharmaceuticals | 220 | 2025-07-28 | 2026-08-17 |
| A Study of Zigakibart in Adults With IgA Nephropathy BION-1301, Placebo - IgA Nephropathy, Immunoglobulin A Nephropathy | Phase 3 | Active not recruiting | Novartis Pharmaceuticals | 383 | 2023-07-06 | 2026-04-01 |
| Atrasentan in Patients With IgA Nephropathy Atrasentan, Placebo, Zigakibart - IgA Nephropathy, Immunoglobulin A Nephropathy | Phase 3 | Active not recruiting | Novartis Pharmaceuticals | 404 | 2020-12-11 | 2026-06-04 |
| Safety and Tolerability of BION-1301 in Healthy Volunteers and Adults With IgA Nephropathy (IgAN) BION-1301 Single Dose, Placebo Single Dose, BION-1301 Multiple Doses - IgA Nephropathy | Phase 1 / Phase 2 | Completed | Novartis Pharmaceuticals | 103 | 2019-04-08 | 2026-06-16 |
Glomerulonephritis, IGA (6) · Glomerulonephritis (3) · Kidney Diseases (3) · Renal Insufficiency, Chronic (3) · Urologic Diseases (3) · Proteinuria (2) · Autoimmune Diseases (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Immune System Diseases (1) · Male Urogenital Diseases (1) · Nephritis (1) · Urogenital Diseases (1)
South Korea (5) · United States (5) · Spain (4) · Taiwan (4) · Argentina (3) · Australia (3) · Brazil (3) · Canada (3) · China (3) · Germany (3) · Italy (3) · Japan (3) · United Kingdom (3) · Czechia (2) · France (2)
PMID 40482854, PMID 38059359, PMID 38299639, PMID 39460694, PMID 40465397, PMID 41442197, PMID 42205925, PMID 42242268
2018 (1)