1 active not recruiting, 1 completed, 1 enrolling by invitation, 1 recruiting. 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Active not recruiting 1, Completed 1, Enrolling by invitation 1, Recruiting 1 |
Follow Vutrisiran: new trials by email Literature Review of Vutrisiran trials Research Report on Vutrisiran
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy Nucresiran, Vutrisiran - Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy, hATTR-PN | Phase 3 | Recruiting | Alnylam Pharmaceuticals | 125 | 2026-02-03 | 2026-10-08 |
| A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy Vutrisiran - Transthyretin Amyloidosis (ATTR) With Cardiomyopathy | Phase 3 | Enrolling by invitation | Alnylam Pharmaceuticals | 700 | 2024-12-03 | 2026-10-21 |
| HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy Vutrisiran, Sterile Normal Saline (0.9% NaCl) - Transthyretin Amyloidosis (ATTR) With Cardiomyopathy | Phase 3 | Active not recruiting | Alnylam Pharmaceuticals | 655 | 2019-11-26 | 2026-11-02 |
| HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis) Patisiran, Vutrisiran - Amyloidosis, Hereditary, Transthyretin Amyloidosis | Phase 3 | Completed | Alnylam Pharmaceuticals | 164 | 2019-02-14 | 2026-01-12 |
Amyloidosis (3) · Amyloidosis, Hereditary, Transthyretin-Related (3) · Amyloidosis, Familial (2) · Cardiomyopathies (2) · Polyneuropathies (1)
Argentina (4) · France (4) · Portugal (4) · South Korea (4) · Spain (4) · Sweden (4) · United Kingdom (4) · United States (4) · Australia (3) · Belgium (3) · Brazil (3) · Canada (3) · Germany (3) · Italy (3) · Japan (3)
PMID 39213194, PMID 35875890, PMID 37523143, PMID 38512694, PMID 39566871, PMID 40099776, PMID 40380962, PMID 40769675, PMID 40770082, PMID 41225306, PMID 42165759, PMID 42201475, PMID 42290201, PMID 42616515, PMID 42646924, PMID 42669065, PMID 42669069, PMID 42669070
2023 (2), 2018 (1), 2025 (1)