8 completed, 3 terminated, 1 active not recruiting, 1 recruiting. 8 Phase 2, 4 Phase 1, 2 Not applicable, 2 Phase 3, 1 Early Phase 1.
Follow vitamin B9: new trials by email Literature Review of vitamin B9 trials Research Report on vitamin B9
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ICOPE INTENSE-K Pilot Study ICOPE intense intervention, Ketone Ester (KE) supplementation, Placebo - Ageing | Not applicable | Recruiting | University Hospital, Toulouse | 40 | 2025-07-09 | 2025-07-23 |
| Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II Periodontitis Vitamin B3 100 MG Oral Tablet, vitamin B9, Placebo - Periodontitis Stage I, Periodontal Diseases | Early Phase 1 | Unknown | Cairo University | 30 | 2022-07-01 | 2022-06-28 |
| Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) Cobalamin, Dexamethasone, Docetaxel - Advanced Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma | Phase 2 / Phase 3 | Active not recruiting | SWOG Cancer Research Network | 82 | 2022-03-15 | 2026-05-18 |
| Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients methylcobalamin, Folic Acid, Placebo for methylcobalamin - Post Operative Cognitive Dysfunction | Not applicable | Terminated | Xijing Hospital | 40 | 2019-01-10 | 2021-08-04 |
| Effect of Preoperative Buccal Misoprostol on Blood Loss in Second-trimester Dilation and Evacuation Abortion Misoprostol, Folic acid - Abortion, Blood Loss | Phase 3 | Terminated | Boston University | 3 | 2011-07-01 | 2017-05-30 |
| Study of Pralatrexate in Female Patients With Previously-treated Breast Cancer Pralatrexate Injection, Vitamin B12, Folic Acid - Breast Cancer, Breast Tumors | Phase 2 | Completed | Acrotech Biopharma Inc. | 22 | 2010-03-01 | 2020-01-07 |
| Pralatrexate and Bexarotene in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma Pralatrexate Injection, Bexarotene Capsules, Vitamin B12 - Cutaneous T-cell Lymphoma, Mycosis Fungoides | Phase 1 | Completed | Acrotech Biopharma Inc. | 34 | 2010-03-01 | 2019-12-18 |
| Study of Pralatrexate to Treat Participants With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma Pralatrexate, Vitamin B12, Folic Acid - Lymphoma, B-Cell | Phase 2 | Completed | Spectrum Pharmaceuticals, Inc | 29 | 2009-09-01 | 2021-11-05 |
| Addition of Modulators of Homocysteine to Adalimumab Therapy in the Treatment of Moderate to Severe Plaque Psoriasis Humira Then Humira plus 3 B vitamins - Psoriasis | Phase 1 / Phase 2 | Terminated | Wayne State University | 8 | 2009-01-01 | 2015-02-04 |
| Study of Pralatrexate to Treat Advanced or Metastatic Relapsed Transitional Cell Carcinoma of the Urinary Bladder Pralatrexate Injection, Vitamin B12, Folic Acid - Carcinoma, Transitional Cell, Bladder Cancer | Phase 2 | Completed | Acrotech Biopharma Inc. | 30 | 2008-07-01 | 2019-12-17 |
| Study of Pralatrexate vs. Erlotinib for Non-Small Cell Lung Cancer After at Least 1 Prior Platinum-based Treatment Pralatrexate, Erlotinib, Vitamin B12 - Non-small Cell Lung Cancer | Phase 2 | Completed | Spectrum Pharmaceuticals, Inc | 201 | 2008-01-01 | 2021-03-05 |
| Study of Pralatrexate in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma Vitamin B12, Folic Acid, Pralatrexate - Cutaneous T-cell Lymphoma | Phase 1 | Completed | Acrotech Biopharma Inc. | 55 | 2007-08-01 | 2020-01-03 |
| Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies Pralatrexate Injection, Gemcitabine Hydrochloride, Vitamin B12 - Relapsed or Refractory Lymphoproliferative Malignancies, Hodgkin's Lymphoma | Phase 1 / Phase 2 | Completed | Acrotech Biopharma Inc. | 119 | 2007-05-01 | 2020-01-07 |
| Phase 2 Trial of Bevacizumab in Combination With Pemetrexed Bevacizumab, Pemetrexed, Vitamin B12 - Non-small Cell Lung Cancer (NSCLC), Lung Cancer | Phase 2 | Completed | Heather Wakelee | 16 | 2006-03-01 | 2017-03-06 |
Recurrence (5) · Carcinoma, Non-Small-Cell Lung (3) · Lung Neoplasms (3) · Neoplasm Metastasis (3) · Lymphoma (2) · Lymphoma, B-Cell (2) · Lymphoma, T-Cell (2) · Lymphoma, T-Cell, Cutaneous (2) · Mycosis Fungoides (2) · Sezary Syndrome (2) · Breast Neoplasms (1) · Carcinoma (1) · Carcinoma, Transitional Cell (1) · Hemorrhage (1) · Hodgkin Disease (1)
Acrotech Biopharma Inc. (5) · Spectrum Pharmaceuticals, Inc (2) · Boston University (1) · Cairo University (1) · Heather Wakelee (1) · SWOG Cancer Research Network (1) · University Hospital, Toulouse (1) · Wayne State University (1) · Xijing Hospital (1)
United States (10) · France (3) · Argentina (2) · Czechia (2) · Hungary (2) · Belgium (1) · Brazil (1) · China (1) · Croatia (1) · India (1) · Italy (1) · Spain (1)
Garry Weems, PharmD (2) · Michael Saunders, MD (2) · Garry Weems, Pharm.D. (1) · Heather A. Wakelee (1) · John M Wrangle (1) · Lize Xiong, M.D., Ph.D. (1) · Pankaj Sharma, MD (1) · Peter J Aronson, MD (1) · Riham Omar, professor (1) · Sarita Sonalkar, MD (1)
2008 (1), U10CA180888 (1)