8 completed, 4 unknown. 9 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 8, Unknown 1 |
| Phase 2 | 5 | Unknown 3, Completed 2 |
Follow ST 1481: new trials by email Literature Review of ST 1481 trials Research Report on ST 1481
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Oral Gimatecan in Platinum-Resistant Epithelial Ovarian, Fallopian Tube or Peritoneal Cancer Gimatecan - Epithelial Ovarian Cancer, Fallopian Tube Cancer | Phase 2 | Unknown | Lee's Pharmaceutical Limited | 46 | 2021-07-01 | 2021-04-19 |
| A Phase II Study of Gimatecan (ST1481) in Locally Advanced or Metastatic Pancreatic Cancer Gimatecan, tegafur, gimeracil and oteracil potassium, gemcitabine - Pancreatic Cancer | Phase 2 | Unknown | Lee's Pharmaceutical Limited | 60 | 2020-12-01 | 2020-10-01 |
| A Study of Gimatecan (ST1481) in Small Cell Lung Cancer Gimatecan - Small Cell Lung Cancer | Phase 2 | Unknown | Lee's Pharmaceutical Limited | 70 | 2020-10-01 | 2020-08-06 |
| A Clinical Study of Gimatecan in Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer Gimatecan 0.6mg/m2/d, 0.8mg/m2/d, 0.4mg/m2/d - Ovarian Epithelial Cancer, Fallopian Tube Cancer | Phase 1 | Unknown | Lee's Pharmaceutical Limited | 12 | 2019-07-11 | 2019-07-23 |
| Phase I Study of Gimatecan in Patients With Myelodysplastic Syndromes Gimatecan - Myelodysplastic Syndromes, MDS | Phase 1 | Completed | M.D. Anderson Cancer Center | 16 | 2007-08-01 | 2015-05-13 |
| A Phase I Dose Escalation Study of LBQ707 (Gimatecan) Administered Orally Twice Per Week to Japanese Patients With Advanced Solid Tumors Gimatecan - Advanced Solid Tumors | Phase 1 | Completed | Novartis | 28 | 2007-05-01 | 2009-11-19 |
| An Extension Trial to a Phase I Dose Escalation Study of Gimatecan Administered Orally 5 Consecutive Days to Japanese Patients With Advanced Solid Tumor Gimatecan - Advanced Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 4 | 2007-01-01 | 2020-12-19 |
| A Dose Escalation of Gimatecan Administered Orally to Japanese Patients With Advanced Solid Tumor. Gimatecan - Advanced Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 19 | 2006-06-01 | 2020-12-19 |
| Dose-escalation Study of Gimatecan Administered in Two Different Schedules in Adult Patients With Advanced Solid Tumors gimatecan - Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 120 | 2006-03-01 | 2013-04-19 |
| Gimatecan in Treating Patients With Recurrent or Progressive Primary Malignant Glioma gimatecan - Brain and Central Nervous System Tumors | Phase 1 / Phase 2 | Completed | Jonsson Comprehensive Cancer Center | 2004-05-01 | 2013-07-18 | |
| This is an Early Study to Investigate the Effect of Gimatecan® in Adults With Malignant Glioma. Gimatecan® (ST 1481) - Malignant Glioma | Phase 1 / Phase 2 | Completed | Sigma-Tau Research, Inc. | 59 | 2002-03-01 | 2009-06-03 |
| This is an Early Study to Investigate the Effect of Gimatecan® in Adults With Solid Tumor Gimatecan® (ST-1481) - Solid Malignancies | Phase 1 | Completed | Sigma-Tau Research, Inc. | 30 | 2002-03-01 | 2009-06-03 |
Carcinoma, Ovarian Epithelial (2) · Fallopian Tube Neoplasms (2) · Astrocytoma (1) · Brain Neoplasms (1) · Central Nervous System Neoplasms (1) · Glioblastoma (1) · Glioma (1) · Gliosarcoma (1) · Leukemia (1) · Myelodysplastic Syndromes (1) · Oligodendroglioma (1) · Pancreatic Neoplasms (1) · Small Cell Lung Carcinoma (1)
Lee's Pharmaceutical Limited (4) · Novartis Pharmaceuticals (3) · Sigma-Tau Research, Inc. (2) · Jonsson Comprehensive Cancer Center (1) · M.D. Anderson Cancer Center (1) · Novartis (1)
United States (4) · China (3) · Japan (3) · Canada (1) · Denmark (1) · France (1) · Germany (1) · Netherlands (1) · Norway (1) · Spain (1)
Hong Zheng, MD (1) · Jorge E. Cortes, MD (1) · Timothy F. Cloughesy, MD (1)