73 completed, 20 unknown, 12 terminated, 4 withdrawn. 70 Phase 2, 31 Phase 3, 11 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 70 | Completed 49, Terminated 11, Unknown 7, Withdrawn 3 |
| Phase 3 | 31 | Completed 17, Unknown 12, Terminated 1, Withdrawn 1 |
| Phase 1 | 11 | Completed 8, Unknown 2, Terminated 1 |
Follow recombinant interferon alfa: new trials by email Literature Review of recombinant interferon alfa trials Research Report on recombinant interferon alfa
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyperthermia and Mitomycin C, Bacillus Calmette-Guerin, or Standard Therapy as Second-Line Therapy in Treating Patients With Recurrent Bladder Cancer BCG solution, recombinant interferon alfa, epirubicin hydrochloride - Bladder Cancer | Phase 3 | Unknown | Cancer Research Campaign Clinical Trials Centre | 242 | 2009-10-01 | 2013-08-12 |
| Biomarkers in Patients With High-Risk Melanoma Receiving High-Dose Interferon Therapy recombinant interferon alfa, proteomic profiling, immunoenzyme technique - Melanoma (Skin) | Completed | ECOG-ACRIN Cancer Research Group | 40 | 2008-01-14 | 2017-05-19 | |
| Fludarabine and Radiation Therapy in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Phase or Accelerated Phase Chronic Myelogenous Leukemia recombinant interferon alfa, therapeutic allogeneic lymphocytes, cyclosporine - Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2005-02-01 | 2011-11-17 |
| Chemoradiation in Locally Advanced Pancreatic Cancer recombinant interferon alfa, cisplatin, fluorouracil - Pancreatic Cancer | Phase 2 | Terminated | Masonic Cancer Center, University of Minnesota | 23 | 2005-01-01 | 2017-12-28 |
| Vaccine Therapy in Treating Patients With HER2/Neu Positive or Negative Stage IV Breast Cancer or Other HER2/Neu Positive Cancers allogeneic GM-CSF-secreting breast cancer vaccine, recombinant interferon alfa, cyclophosphamide - Breast Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 / Phase 2 | Terminated | Wiseman Research Initiatives LLC | 24 | 2004-11-01 | 2018-02-05 |
| Sorafenib and Interferon Alfa in Treating Patients With Locally Advanced or Metastatic Kidney Cancer sorafenib tosylate, recombinant interferon alfa, laboratory biomarker analysis - Clear Cell Renal Cell Carcinoma, Papillary Renal Cell Carcinoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 40 | 2004-10-01 | 2013-07-02 |
| DC Vaccine Combined With IL-2 and IFNα-2a in Treating Patients With mRCC Aldesleukin,, autologous tumor cell vaccine, recombinant interferon alfa - Kidney Cancer | Phase 2 | Completed | Dartmouth-Hitchcock Medical Center | 18 | 2003-12-01 | 2018-06-26 |
| Short-Term Low-Dose Interferon Alfa in Treating Patients With Cancer of the Urothelium Recombinant Interferon Alfa - Bladder Cancer, Urethral Cancer | Phase 1 | Completed | M.D. Anderson Cancer Center | 33 | 2003-12-01 | 2015-05-14 |
| Isotretinoin, Interferon Alfa, and Vitamin E in Treating Patients With Stage III or Stage IV Head and Neck Cancer recombinant interferon alfa, vitamin E, isotretinoin - Head and Neck Cancer | Phase 3 | Completed | Eastern Cooperative Oncology Group | 2003-11-26 | 2023-06-15 | |
| Interferon Alfa-2b With or Without Bevacizumab in Treating Patients With Advanced Renal Cell Carcinoma (Kidney Cancer) bevacizumab, recombinant interferon alfa - Kidney Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 732 | 2003-10-01 | 2016-07-06 |
| Oblimersen and Interferon Alfa in Treating Patients With Metastatic Renal Cell Cancer recombinant interferon alfa, oblimersen sodium, pharmacological study - Recurrent Renal Cell Cancer, Stage IV Renal Cell Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 41 | 2003-08-01 | 2013-08-26 |
| Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With HTLV-1-Related Adult T-Cell Leukemia/Lymphoma filgrastim, recombinant interferon alfa, Etoposide - Lymphoma | Phase 2 | Completed | AIDS Malignancy Consortium | 19 | 2002-10-01 | 2016-02-03 |
| Cisplatin, Metronomic Low-Dose Interferon Alfa, Gemcitabine, and Fever-Range Whole-Body Hyperthermia in Treating Patients With Inoperable or Metastatic Pancreatic Cancer recombinant interferon alfa, cisplatin, gemcitabine hydrochloride - Pancreatic Cancer | Phase 2 | Unknown | The University of Texas Health Science Center, Houston | 48 | 2002-07-01 | 2012-02-13 |
| Interferon Alfa With or Without Interleukin-2 and Fluorouracil in Treating Patients With Advanced Metastatic Kidney Cancer aldesleukin, recombinant interferon alfa, fluorouracil - Kidney Cancer | Phase 3 | Completed | Medical Research Council | 670 | 2002-07-01 | 2013-12-19 |
| Imatinib Mesylate With or Without Interferon Alfa or Cytarabine Compared With Interferon Alfa Followed by Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia recombinant interferon alfa, cytarabine, hydroxyurea - Leukemia | Phase 3 | Completed | Heidelberg University | 1551 | 2002-06-01 | 2018-05-03 |
| Chemotherapy, Interferon Alfa, and Radiation Therapy in Treating Patients Who Have Undergone Surgery For Pancreatic Cancer Recombinant Interferon Alfa, Cisplatin, Fluorouracil - Pancreatic Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 29 | 2002-05-01 | 2012-02-15 |
| Chemotherapy and Biological Therapy in Treating Patients With Locally Advanced or Metastatic Kidney Cancer recombinant interferon alfa, temsirolimus - Kidney Cancer | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 2002-04-01 | 2013-06-05 | |
| Interferon Alfa and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia recombinant interferon alfa, imatinib mesylate - Leukemia | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 2002-04-01 | 2013-06-05 | |
| Bevacizumab With or Without Interferon Alfa in Treating Patients With Metastatic Malignant Melanoma Recombinant Interferon Alfa, Bevacizumab - Recurrent Melanoma, Stage IV Skin Melanoma | Phase 2 | Completed | National Cancer Institute (NCI) | 57 | 2001-11-01 | 2016-03-17 |
| Biological Therapy and Chemotherapy in Treating Patients With Metastatic Kidney Cancer or Colorectal Cancer recombinant interferon alfa, sargramostim, therapeutic autologous lymphocytes - Colorectal Cancer, Kidney Cancer | Phase 1 / Phase 2 | Completed | St. Luke's Medical Center | 60 | 2001-11-01 | 2013-06-26 |
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Leukemia (25) · Carcinoma, Renal Cell (22) · Kidney Neoplasms (21) · Leukemia, Myeloid, Chronic-Phase (21) · Melanoma (20) · Lymphoma (16) · Multiple Myeloma (16) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (13) · Neoplasms, Plasma Cell (13) · Lymphoma, Follicular (11) · Leukemia, Lymphocytic, Chronic, B-Cell (8) · Burkitt Lymphoma (7) · Lymphoma, B-Cell, Marginal Zone (7) · Lymphoma, Large B-Cell, Diffuse (7) · Lymphoma, Large-Cell, Immunoblastic (7)
National Cancer Institute (NCI) (10) · Eastern Cooperative Oncology Group (8) · Hoag Memorial Hospital Presbyterian (6) · European Organisation for Research and Treatment of Cancer - EORTC (5) · M.D. Anderson Cancer Center (5) · SWOG Cancer Research Network (5) · Fred Hutchinson Cancer Center (4) · Masonic Cancer Center, University of Minnesota (4) · Memorial Sloan Kettering Cancer Center (4) · Medical Research Council (3) · City of Hope Medical Center (2) · ECOG-ACRIN Cancer Research Group (2) · Herbert Irving Comprehensive Cancer Center (2) · Northwestern University (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2)
United States (88) · United Kingdom (13) · Belgium (7) · Netherlands (7) · Germany (6) · Italy (6) · Switzerland (6) · Australia (3) · Austria (3) · Canada (3) · France (3) · Puerto Rico (3) · South Africa (3) · Turkey (Türkiye) (3) · Hungary (2)
Robert O. Dillman, MD, FACP (6) · Charles L. Wiseman, MD, FACP (3) · Ruediger Hehlmann, MD (3) · Catherine M. Verfaillie, MD (2) · Jane N. Winter, MD (2) · Joan M.C. Bull, MD (2) · John M. Kirkwood, MD (2) · John P. Hanson, MD (2) · Laura F. Hutchins, MD (2) · Lawrence E. Flaherty, MD (2) · Leo I. Gordon, MD (2) · Richard E. Champlin, MD (2) · Scott Wadler, MD (2) · William Carson (2) · William E. Carson, MD (2)
PMID 12074329, PMID 12637609, PMID 14508361, PMID 14581348, PMID 14665609, PMID 15010373, PMID 15102658, PMID 15308571, PMID 15961764, PMID 16170182, PMID 16198768, PMID 16249352, PMID 16260693, PMID 16432076, PMID 16706633, PMID 17023156, PMID 17151364, PMID 17366595, PMID 17443000, PMID 17932881, PMID 18077791, PMID 18162124, PMID 18166796, PMID 18608594, PMID 18645482, PMID 18794104, PMID 18936475, PMID 19001327, PMID 19117345, PMID 19204798, PMID 19228745, PMID 19622576, PMID 19648168, PMID 19880501, PMID 19965667, PMID 20142590, PMID 20153039, PMID 20368558, PMID 20679528, PMID 21087856, PMID 21422420, PMID 21546857, PMID 22021080, PMID 22442350, PMID 22689675, PMID 23515925, PMID 24162333, PMID 24297946, PMID 24622328, PMID 24658964
P30CA016672 (5), U10CA032102 (4), P30CA006973 (2), P30CA033572 (2), U10CA031946 (2), N01CM17101 (1), N01CM62207 (1), P01CA075606 (1), P30CA006927 (1), P30CA013330 (1), P30CA016058 (1), P30CA023108 (1), P50CA091846 (1), R01CA095648 (1), R21CA093071 (1)