5 recruiting, 4 completed, 3 active not recruiting, 2 not yet recruiting. 16 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Recruiting 5, Completed 4, Active not recruiting 3, Not yet recruiting 2, Unknown 2 |
Follow Radiation Dose Hypofractionation: new trials by email Literature Review of Radiation Dose Hypofractionation trials Research Report on Radiation Dose Hypofractionation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) and Pembrolizumab (MK-3475A) in Participants With Bladder Cancer (MK-2870-055) Sac-TMT, Pembrolizumab and Berahyaluronidase alfa, Cisplatin - Bladder Cancer | Phase 3 | Not yet recruiting | Merck Sharp & Dohme LLC | 400 | 2026-10-20 | 2026-09-21 |
| Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309) Enfortumab vedotin, Conventional Radiotherapy, Hypofractionated Radiotherapy - Urothelial Cancer, Urinary Bladder Neoplasms | Phase 3 | Recruiting | Astellas Pharma Global Development, Inc. | 390 | 2026-05-11 | 2026-10-28 |
| Hypofractionated vs Conventional RT After Prosthetic Breast Reconstruction hypofractionated radiotherapy, conventional fractionated radiotherapy - Breast Cancer, Breast Reconstruction | Phase 3 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 506 | 2026-03-27 | 2026-06-22 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study Biospecimen Collection, Cisplatin, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 486 | 2025-10-07 | 2026-10-23 |
| Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma Hypofractionated radiotherapy, Conventional radiotherapy, Temozolomide - Glioblastoma | Phase 3 | Recruiting | Severance Hospital | 178 | 2025-02-01 | 2025-05-21 |
| SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma Antiandrogen Therapy, Biospecimen Collection, Hypofractionated Radiation Therapy - Biochemically Recurrent Prostate Carcinoma, Oligometastatic Prostate Carcinoma | Phase 3 | Active not recruiting | Mayo Clinic | 118 | 2024-04-04 | 2026-09-17 |
| Hypo Versus Conventional Fractionation in Reconstructed-Breast Cancer Mastectomy Patients Hypofractionation, Conventional Fractionation - Breast Cancer, Radiotherapy; Complications | Phase 3 | Not yet recruiting | Seoul National University Bundang Hospital | 622 | 2022-04-01 | 2022-03-11 |
| Conventional or Hypofractionated Radiation Therapy in Treating Patients With Prostate Cancer Hypofractionated Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration - Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8 | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 186 | 2019-05-30 | 2026-05-20 |
| Hypofractionated Irradiation At Regional Nodal Area for Breast Cancer Vs Existed Standard Treatment Hypofractionated radiotherapy, Conventional radiotherapy - Breast Cancer | Phase 3 | Recruiting | Ruijin Hospital | 801 | 2019-02-21 | 2022-06-02 |
| HFSRT With Concurrent TMZ for Large BMs Temozolomide, hypofractionated radiotherapy - Brain Metastases, Chemotherapy | Phase 3 | Unknown | Chinese Academy of Medical Sciences | 224 | 2018-12-03 | 2019-07-23 |
| Hypofractionated Radiation Therapy in Preventing Recurrence in Patients With Breast Cancer After Surgery Hypofractionated Radiation Therapy, Quality-of-Life Assessment, Radiation Therapy - Stage I Breast Cancer AJCC v7, Stage IA Breast Cancer AJCC v7 | Phase 3 | Completed | Mayo Clinic | 107 | 2018-02-07 | 2024-05-02 |
| Post Mastectomy Hypofractionated Radiotherapy in High Risk Breast Cancer Hypofractionated radiotherapy, Conventional fractionated radiotherapy - Breast Cancer | Phase 3 | Unknown | Ahmed Ahm | 60 | 2017-10-01 | 2017-10-24 |
| Hypofractionated Radiation Therapy or Conventional Radiation Therapy After Surgery in Treating Patients With Prostate Cancer Hypofractionated Radiation Therapy, Laboratory Biomarker Analysis, Quality-of-Life Assessment - Prostate Adenocarcinoma, Stage I Prostate Adenocarcinoma AJCC v7 | Phase 3 | Completed | NRG Oncology | 296 | 2017-07-28 | 2026-07-09 |
| Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate hypofractionation, conventional - Prostate Cancer | Phase 3 | Active not recruiting | Sir Mortimer B. Davis - Jewish General Hospital | 329 | 2012-01-01 | 2024-12-04 |
| Hypofractionated Radiotherapy Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children Hypofractionated radiotherapy, Conventional arm - Pediatric Brain Stem Glioma | Phase 3 | Completed | Children's Cancer Hospital Egypt 57357 | 64 | 2010-05-01 | 2012-07-09 |
| A Phase Ⅲ Randomized Clinical Trial of Postmastectomy Hypofractionation Radiotherapy in High-risk Breast Cancer hypofractionation radiotherapy, conventional fractionation radiotherapy - Breast Cancer | Phase 3 | Completed | Chinese Academy of Medical Sciences | 810 | 2008-06-01 | 2018-10-11 |
Breast Neoplasms (6) · Prostatic Neoplasms (3) · Urinary Bladder Neoplasms (3) · Brain Neoplasms (1) · Carcinoma, Transitional Cell (1) · Female Urogenital Diseases (1) · Glioblastoma (1) · Male Urogenital Diseases (1) · Neoplasms (1) · Neoplasms by Site (1) · Urinary Bladder Diseases (1) · Urogenital Diseases (1) · Urogenital Neoplasms (1) · Urologic Diseases (1) · Urologic Neoplasms (1)
Chinese Academy of Medical Sciences (2) · Mayo Clinic (2) · NRG Oncology (2) · Ahmed Ahm (1) · Astellas Pharma Global Development, Inc. (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Children's Cancer Hospital Egypt 57357 (1) · M.D. Anderson Cancer Center (1) · Merck Sharp & Dohme LLC (1) · Ruijin Hospital (1) · Seoul National University Bundang Hospital (1) · Severance Hospital (1) · Sir Mortimer B. Davis - Jewish General Hospital (1)
United States (6) · Canada (4) · China (4) · Egypt (2) · South Korea (2) · Switzerland (1) · Taiwan (1)
Carlos E. Vargas, MD (1) · Carlos Vargas (1) · Chan Woo Wee, MD, PhD (1) · In Ah Kim, MD, PhD (1) · In Ah Kim, MD. PhD. (1) · Jia-Yi Chen (1) · Jianping Xiao, Dr (1) · Mark K Buyyounouski (1) · Quynh-Nhu Nguyen (1) · Scott E Delacroix (1) · Tamim Niazi, MD (1) · Ye-xiong Li, M.D. (1) · Zejing Wang, MD/PhD (1)
PMID 24560760, PMID 30711522, PMID 33577365, PMID 33933925, PMID 36581983, PMID 37224928, PMID 37914139, PMID 38483412, PMID 42805199
U10CA180868 (2)