7 completed, 2 recruiting. 5 Not applicable, 2 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 4, Recruiting 1 |
| Phase 4 | 2 | Completed 1, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Phenylalanine: new trials by email Literature Review of Phenylalanine trials Research Report on Phenylalanine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers Phenylalanine (Phe), Placebo - Carrier of Phenylketonuria, Healthy | Not applicable | Recruiting | University of Missouri-Columbia | 36 | 2025-12-19 | 2026-10-22 |
| Understanding the Efficacy of Dietary Supplement on Fungal Mycobiota in Healthy Volunteers: A Pilot Study L-Phenylalanine 500 mg Veg Capsule product - Gut Microbiome, Gut Health | Phase 4 | Recruiting | Weill Medical College of Cornell University | 20 | 2024-10-17 | 2026-06-26 |
| Phe for Me? The Effects of L-Phe on PKU Carriers and Non-carriers L-Phenylalanine - Autosomal Recessive Disorder (Genetic Carriers of PKU) | Not applicable | Completed | University of Guelph | 56 | 2024-06-18 | 2026-05-04 |
| PKU Carriers Trial (Pilot Study): Impact on Cognition, Mental Health, Blood Pressure and Metabolism L-Phenylalanine - Autosomal Recessive Disorder (Genetic Carriers of PKU) | Not applicable | Completed | University of Guelph | 7 | 2023-07-01 | 2024-12-06 |
| Phenylalanine and Its Impact on Cognition Phenylalanine, Placebo - Phenylketonuria | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 90 | 2019-08-19 | 2023-03-07 |
| Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults Essential Amino Acids (EAA), Placebo (Alanine) - Muscle Atrophy, Quality of Life | Phase 2 | Completed | University of Oregon | 80 | 2014-12-01 | 2024-07-23 |
| Kuvan® in Phenylketonuria Patients Less Than 4 Years Old Kuvan®, Phenylalanine (Phe)-restricted diet - Phenylketonuria | Phase 3 | Completed | BioMarin Pharmaceutical | 56 | 2011-06-01 | 2017-09-15 |
| Estrogen and Serotonin on Changing Brain Chemistry estrogen patch, Amino acids, Placebo Patch - Menopause | Not applicable | Completed | University of Colorado, Denver | 47 | 2010-03-04 | 2021-04-02 |
| Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation Essential amino acids, Alanine - Osteoarthritis | Not applicable | Completed | University of Oregon | 60 | 2008-06-01 | 2014-12-04 |
Phenylketonurias (2) · Memory Disorders (1) · Muscular Atrophy (1) · Osteoarthritis (1)
University of Guelph (2) · University of Oregon (2) · BioMarin Pharmaceutical (1) · Insel Gruppe AG, University Hospital Bern (1) · University of Colorado, Denver (1) · University of Missouri-Columbia (1) · Weill Medical College of Cornell University (1)
United States (5) · Canada (2) · Austria (1) · Belgium (1) · Czechia (1) · Germany (1) · Italy (1) · Netherlands (1) · Slovakia (1) · Switzerland (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Cynthia Neill Epperson, M.D. (1) · Hans C Dreyer, PT, PhD (1) · Ignacio Alvarez, MD (1) · Iliyan D Iliev, PhD (1) · Regula Everts, Prof. Dr. phil. (1)
PMID 22204954, PMID 24135139, PMID 26733251, PMID 26829246, PMID 28274234, PMID 30280129, PMID 31343947, PMID 32054509, PMID 34344399, PMID 38569786, PMID 39146838, PMID 41555437
2009 (1), 2018 (1), K01HD057332 (1), P50MH099910 (1), R01AG046401 (1), R21HD115129 (1)