31 completed, 7 terminated, 6 unknown, 2 active not recruiting. 20 Phase 2, 18 Phase 1, 4 Phase 3, 2 Not applicable.
Follow pharmacogenomic studies: new trials by email Literature Review of pharmacogenomic studies trials Research Report on pharmacogenomic studies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma BTK inhibitor PCI-32765, rituximab, bendamustine hydrochloride - Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma | Phase 1 | Active not recruiting | Kami Maddocks, MD | 48 | 2014-03-26 | 2026-07-22 |
| Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery selumetinib, Akt inhibitor MK2206, laboratory biomarker analysis - Adenocarcinoma of the Gallbladder, Adenocarcinoma With Squamous Metaplasia of the Gallbladder | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2013-01-01 | 2014-09-09 | |
| Dabrafenib and Pazopanib Hydrochloride in Treating Patients With Advanced Malignant Tumors dabrafenib, pazopanib hydrochloride, Correlative studies - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | Manisha Shah | 23 | 2012-11-19 | 2019-03-01 |
| Capecitabine and Celecoxib in Patients With Solid Cancers That Have Been Previously Treated With Standard Therapies capecitabine, celecoxib, pharmacological study - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Terminated | University of Chicago | 21 | 2012-08-29 | 2018-05-30 |
| Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Measuring Effects of Pazopanib Hydrochloride in Patients With Metastatic Kidney Cancer pazopanib hydrochloride, laboratory biomarker analysis, dynamic contrast-enhanced magnetic resonance imaging - Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Cancer | Not applicable | Terminated | University of Chicago | 20 | 2012-06-01 | 2017-06-08 |
| Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer stereotactic body radiation therapy, carboplatin, gemcitabine hydrochloride - Leydig Cell Tumor, Ovarian Sarcoma | Phase 1 | Completed | Case Comprehensive Cancer Center | 12 | 2012-05-01 | 2015-08-04 |
| Bortezomib and Rituximab in Treating Patients With Mantle Cell Lymphoma Who Have Previously Undergone Stem Cell Transplantation bortezomib, rituximab, laboratory biomarker analysis - Contiguous Stage II Mantle Cell Lymphoma, Noncontiguous Stage II Mantle Cell Lymphoma | Phase 2 | Completed | City of Hope Medical Center | 23 | 2011-10-03 | 2023-07-27 |
| Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1 DNA analysis, RNA analysis, gene expression analysis - Sarcoma | Completed | Children's Oncology Group | 20 | 2011-09-01 | 2016-05-18 | |
| Study of Gemtuzumab Ozogamicin Therapy in DNA Samples From Patients With Acute Myeloid Leukemia Treated on COG-AAML0531 DNA analysis, gene expression analysis, laboratory biomarker analysis - Leukemia | Completed | Children's Oncology Group | 1000 | 2011-07-01 | 2016-05-19 | |
| Pazopanib Hydrochloride or a Placebo in Treating Patients With Non-Small Cell Lung Cancer Who Have Received First-Line Chemotherapy pazopanib hydrochloride, laboratory biomarker analysis, pharmacogenomic studies - Lung Cancer | Phase 2 / Phase 3 | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 102 | 2011-07-01 | 2018-07-12 |
| Study of Blood and Tissue Samples in Children With Newly Diagnosed Acute Lymphoblastic Leukemia gene expression analysis, mutation analysis, polymorphism analysis - Leukemia, Lymphoma | Unknown | European Organisation for Research and Treatment of Cancer - EORTC | 1200 | 2011-06-01 | 2017-07-28 | |
| TLR8 Agonist VTX-2337 and Cetuximab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Squamous Cell Cancer of Head and Neck TLR8 agonist VTX-2337, cetuximab, laboratory biomarker analysis - Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Phase 1 | Completed | University of Washington | 13 | 2011-06-01 | 2015-03-05 |
| Erlotinib Hydrochloride and Radiation Therapy in Stage III-IV Squamous Cell Cancer of the Head and Neck erlotinib hydrochloride, intensity-modulated radiation therapy, pharmacogenomic studies - Stage III Squamous Cell Carcinoma of the Hypopharynx, Stage III Squamous Cell Carcinoma of the Larynx | Phase 2 | Terminated | Case Comprehensive Cancer Center | 2 | 2011-01-01 | 2020-05-12 |
| Transarterial Chemoembolization Using Doxorubicin Beads With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery doxorubicin-eluting beads, sorafenib tosylate, laboratory biomarker analysis - Liver Cancer | Phase 3 | Unknown | University College, London | 412 | 2010-11-01 | 2011-05-13 |
| Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL) carfilzomib, Cytokine Assessment, Pharmacodynamic Studies - B-cell Chronic Lymphocytic Leukemia, Hematopoietic/Lymphoid Cancer | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 21 | 2010-10-01 | 2016-05-09 |
| Pralatrexate and Fluorouracil in Treating Patients With Recurrent Solid Tumors pralatrexate, fluorouracil, laboratory biomarker analysis - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | University of Nebraska | 29 | 2010-09-14 | 2023-12-26 |
| Low-Dose Tamoxifen Citrate in Reducing Breast Cancer Risk in Radiation-Induced Cancer Survivors Tamoxifen Citrate, Placebo, Digital mammography - Breast Cancer | Phase 2 | Active not recruiting | University of Alabama at Birmingham | 84 | 2010-09-01 | 2026-01-05 |
| AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphoma Pharmacodynamic Studies, Fatigue Inventory, Pharmacogenomic studies - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Amir Mortazavi | 44 | 2010-05-04 | 2018-06-04 |
| Alvespimycin Hydrochloride in Treating Patients With Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-Cell Prolymphocytic Leukemia alvespimycin hydrochloride, diagnostic laboratory biomarker analysis, pharmacogenomic studies - B-cell Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 30 | 2010-05-01 | 2015-11-04 |
| Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal Cancer FOLFIRI regimen, fluorouracil, irinotecan hydrochloride - Colorectal Cancer | Phase 2 | Completed | Cardiff University | 111 | 2010-04-01 | 2014-07-08 |
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Breast Neoplasms (8) · Leukemia, Lymphocytic, Chronic, B-Cell (6) · Lymphoma, B-Cell, Marginal Zone (6) · Lymphoma, Mantle-Cell (6) · Lymphoma, Follicular (5) · Lymphoma, Large B-Cell, Diffuse (5) · Lymphoma, Non-Hodgkin (5) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Burkitt Lymphoma (4) · Carcinoma, Non-Small-Cell Lung (4) · Colorectal Neoplasms (4) · Congenital Abnormalities (4) · Hodgkin Disease (4) · Leukemia, Myeloid, Acute (4) · Leukemia, Prolymphocytic (4)
National Cancer Institute (NCI) (10) · Mayo Clinic (3) · University of Nebraska (3) · Case Comprehensive Cancer Center (2) · Children's Oncology Group (2) · City of Hope Medical Center (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · University of Chicago (2) · Amir Mortazavi (1) · Cancer Research UK (1) · Cardiff University (1) · Federation Francophone de Cancerologie Digestive (1) · Fred Hutchinson Cancer Center (1) · Institut Cancerologie de l'Ouest (1) · Institut Curie (1)
United States (30) · France (6) · United Kingdom (5) · Belgium (2) · Canada (2) · Singapore (2) · Australia (1) · Egypt (1) · Germany (1) · Greece (1) · Netherlands (1) · Portugal (1) · Slovenia (1)
James N. Ingle, MD (2) · Amir Mortazavi, MD (1) · Andrew Rezvani (1) · Anna Pavlick (1) · Anne Thomas, MD (1) · Barry J.A. Laird, MD (1) · Charles Rudin (1) · Donald W. Northfelt, M.D. (1) · Elizabeth C. Reed, MD (1) · Erick Gamelin, MD (1) · Hedy Kindler (1) · Helene Cave (1) · Jatinder Lamba, MD (1) · Jean Grem (1) · Jeffrey Jones (1)
PMID 20098694, PMID 21880792, PMID 24100924, PMID 25355819, PMID 26242208, PMID 26928328, PMID 26943915, PMID 27634566, PMID 28270022, PMID 28411282, PMID 28654574, PMID 29954415, PMID 30181415, PMID 31182436, PMID 33492438, PMID 33555272, PMID 34028627, PMID 34048275, PMID 34616010
P30CA015083 (4), P30CA016058 (2), P30CA036727 (2), N01CM00070 (1), N01CM17103 (1), N01CM62201 (1), N01CM62205 (1), N01CM62209 (1), P01HL036444 (1), P30CA015704 (1), P30CA016086 (1), P30CA022453 (1), P30CA033572 (1), R01CA140245 (1), U01CA062475 (1)