9 completed, 3 not yet recruiting, 3 unknown, 1 recruiting. 11 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 4, Not yet recruiting 3, Unknown 3, Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow opioid free anesthesia: new trials by email Literature Review of opioid free anesthesia trials Research Report on opioid free anesthesia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison Between Opioid-sparing Anesthesia Guided by the CARDEAN® Index and Opioid-free Anesthesia During Total Hip Arthroplasty Titrated Opioid Sparing Anesthesia, opioid free anesthesia - Total Hip Arthroplasty (THA) | Not applicable | Not yet recruiting | Pole Sante Oreliance, Polyclinique des Longues Allees | 140 | 2026-09-15 | 2026-08-05 |
| Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries With Cardiopulmonary Bypass in Enhanced Recovery After Surgeries Opioid free anesthesia, Opioid based Anesthesia - CABG, Dexmedetomidine | Not applicable | Not yet recruiting | Ain Shams University | 60 | 2026-01-01 | 2026-01-22 |
| The Effect of Opioid Free Anesthesia Using Ultrasound-Guided Bilateral Transversus Abdominus Plane Block and Dexmedetomidine Infusion Opioid Free Anesthesia, Control group (general anesthesia) - Anesthesia, Opioid | Not applicable | Not yet recruiting | Tanta University | 150 | 2025-08-30 | 2025-08-11 |
| Effect of Patient Preference for Intraoperative Opioid Use on Early Postoperative Quality of Recovery Opioid based Anesthesia, opioid free anesthesia - Opioid Analgesia, Quality of Recovery (QoR-15) | Not applicable | Completed | University of California, Los Angeles | 240 | 2025-03-24 | 2025-06-27 |
| Opioid Free Anesthesia for Laparoscopic Cholecystectomy Erector Spinae Block, Opioid Analgesic - Analgesia | Phase 4 | Completed | Muhammad Haroon Anwar | 72 | 2024-01-15 | 2024-10-01 |
| Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery opioid free anesthesia, Opiod Free Anesthesia with TCI ELEVELD - Opioid Use, Bariatric Surgery Candidate | Not applicable | Recruiting | G.Gennimatas General Hospital | 70 | 2024-01-10 | 2026-05-06 |
| Opioid-free Vs Traditional Balanced Anesthesia in Laparoscopic Colorectal Surgery Opioid free anesthesia, Opioid based Anesthesia - Colorectal Surgery | Phase 3 | Completed | Unai Ortega Mera | 120 | 2022-05-15 | 2024-10-30 |
| Venous Cannulation Pain to Guide Choice of Anesthetic Method High-pain multimodal anesthesia with opioids, Low-pain opioid free, Standard of care - Pain, Postoperative, Pain Prediction | Not applicable | Completed | Region Halland | 270 | 2022-03-01 | 2025-04-08 |
| OFA in Thoracic Surgery opioid free anesthesia, Opioid-sparing anesthesia - Thoracic Cancer | Not applicable | Unknown | Shanghai Zhongshan Hospital | 60 | 2021-10-01 | 2022-04-27 |
| Postoperative Opioid-Sparing Effect of a Pecto-Intercostal Fascial Block and Opioid-Free Anesthesia. Opioid Free Anesthesia, Traditional Anesthetic Regimen - Opioid Free Anaesthesia, Opioid Anaesthesia | Not applicable | Unknown | Algemeen Stedelijk Ziekenhuis | 64 | 2021-05-01 | 2021-04-22 |
| Opioid-free Anesthesia in VATS Lung Resection Paravertebral block+Anterior serratus plane block, opioid free anesthesia, opioid based anesthesia - Opioid Free Anesthesia | Not applicable | Unknown | Peking University People's Hospital | 100 | 2020-08-01 | 2020-08-11 |
| Opioid Free Anesthesia in Breast Cancer Surgery paravertebral block, opioid free anesthesia, sham block - Opioid Free Anesthesia | Not applicable | Completed | Peking University People's Hospital | 80 | 2020-07-01 | 2022-04-05 |
| Opioid Free Anesthesia in Maxillofacial Surgery opioid free anesthesia - Maxillofacial Surgery | Not applicable | Completed | Université NAZI BONI | 66 | 2019-02-15 | 2021-09-02 |
| Opioid Free Anaesthesia in Oncologic Gynaecological Surgery: Is There Any Benefit? Opioid - Cervix Cancer, Endometrial Cancer | Completed | Instituto de Investigación Hospital Universitario La Paz | 132 | 2019-02-02 | 2022-07-07 | |
| Impact of OFA During LPV on Postoperative Oxygen Saturation opioid anesthesia, opioid free anesthesia - Decreased Lung Compliance, Oxygen Requirement | Completed | AZ Sint-Jan AV | 64 | 2018-08-01 | 2019-12-03 | |
| Impact of Opioid Free Anesthesia on Outcome After DIEPflap Surgery opioid free anesthesia - Major and Minor Surgical Complications | Completed | AZ Sint-Jan AV | 204 | 2014-01-01 | 2021-02-23 |
Agnosia (3) · Pain, Postoperative (2) · Breast Neoplasms (1) · Endometrial Neoplasms (1) · Obesity (1) · Obesity, Morbid (1) · Ovarian Neoplasms (1) · Uterine Cervical Neoplasms (1)
AZ Sint-Jan AV (2) · Peking University People's Hospital (2) · Ain Shams University (1) · Algemeen Stedelijk Ziekenhuis (1) · G.Gennimatas General Hospital (1) · Instituto de Investigación Hospital Universitario La Paz (1) · Muhammad Haroon Anwar (1) · Pole Sante Oreliance, Polyclinique des Longues Allees (1) · Region Halland (1) · Shanghai Zhongshan Hospital (1) · Tanta University (1) · Unai Ortega Mera (1) · University of California, Los Angeles (1) · Université NAZI BONI (1)
China (3) · Belgium (2) · Spain (2) · Burkina Faso (1) · Egypt (1) · France (1) · Greece (1) · Pakistan (1) · Sweden (1) · United States (1)
Alain Traore, Professor (1) · Anna KM Persson, PhD, MD (1) · Bertille Ki, Professor (1) · Changhong Miao (1) · Charles Ilboudo, Doctor (1) · Cheick Bougouma, Doctor (1) · Feng Yi, MD,PhD (1) · Flavien Kabore, Professor (1) · Ismael Guibla, Doctor (1) · Jan Paul Mulier (1) · Jean Paul Lechat, Doctor (1) · Koen Lapage, M.D. (1) · Marco Lanckneus, MD (1) · Merihan Ahmed, Resident (1)
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