3 completed, 3 recruiting, 1 terminated. 2 Phase 1, 2 Phase 2, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Completed 1, Recruiting 1 |
| Phase 2 | 2 | Recruiting 2 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
Follow norflurane: new trials by email Literature Review of norflurane trials Research Report on norflurane
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Compare Safety of 4 Weeks Exposure to Propellants Hydrofluoroalkane 1,1-difluoroethane (HFA-152a) and HFA-1,1,1,2-tetrafluoroethane (134a) HFA-152a, HFA-134a - Asthma | Phase 3 | Recruiting | GlaxoSmithKline | 110 | 2026-09-01 | 2026-11-05 |
| Therapeutic Equivalence of CHF5993 pMDI 100/6/12.5 µg HFA-152a in Subjects With Mild to Moderate Asthma CHF5993 pMDI with HFA-152a, CHF5993 pMDI with HFA-134a, CHF718 pMDI with HFA-134a - Asthma | Phase 2 | Recruiting | Chiesi Farmaceutici S.p.A. | 780 | 2025-12-17 | 2026-06-25 |
| Study of the Effect of HFA-152a and HFA-134a Propellants on Mucociliary Clearance in Healthy Participants HFA-152a, HFA-134a, Radiolabeled saline solution - Asthma | Phase 1 | Completed | GlaxoSmithKline | 24 | 2024-07-29 | 2026-04-14 |
| Advair HFA in Healthy and HAPE Predisposed Subjects Advair HFA, Placebo - Altitude Edema | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 60 | 2023-12-12 | 2025-09-22 |
| Study to Assess Effect of Next-Generation Propellant MDI on Mucociliary Clearance Vs. HFA Propellant MDI in Healthy Participants HFO-1234ze(E), HFA-134a - Mucociliary Clearance | Phase 3 | Completed | AstraZeneca | 35 | 2023-06-14 | 2026-02-25 |
| Enhancing Anaesthetic Success in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Comparative Randomized Controlled Trial Dexamethasone sodium phosphate injection, 1,1,1,2 tetrafluoroethane, intraoral soft tissue cryotherapy - Pulpitis - Irreversible | Phase 4 | Completed | Ain Shams University | 188 | 2023-02-01 | 2025-05-09 |
| Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage Lidocaine, Vapocoolant - Abscess | Phase 4 | Terminated | Albert Einstein Healthcare Network | 21 | 2012-08-01 | 2020-03-19 |
Asthma (3) · Abscess (1) · Altitude Sickness (1) · Bronchial Spasm (1) · Furunculosis (1) · Hypoxia (1)
GlaxoSmithKline (2) · Ain Shams University (1) · Albert Einstein Healthcare Network (1) · AstraZeneca (1) · Chiesi Farmaceutici S.p.A. (1) · University of Colorado, Denver (1)
United Kingdom (4) · United States (4) · Argentina (2) · Bosnia and Herzegovina (1) · Bulgaria (1) · Canada (1) · Czechia (1) · Egypt (1) · Germany (1) · Hungary (1) · Latvia (1) · Mexico (1) · Romania (1) · Serbia (1) · Slovakia (1)
Andreas Schmid, MD (1) · Douglas Conrad, MD (1) · James P Maloney, MD (1) · Joseph D'Orazio, MD (1) · Peter Mogayzel, MD, PhD, MBA (1) · Timothy Corcoran, PhD (1) · William D Bennett, PhD (1)
2025 (1)