13 completed, 1 withdrawn. 5 Phase 1, 4 Not applicable, 3 Phase 2, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 5 |
| Not applicable | 4 | Completed 4 |
| Phase 2 | 3 | Completed 3 |
| Phase 4 | 3 | Completed 2, Withdrawn 1 |
Follow Malarone: new trials by email Literature Review of Malarone trials Research Report on Malarone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Atoguanil BA Study Atoguanil, Malarone - Bioavailability | Phase 1 | Completed | Medicines for Malaria Venture | 16 | 2021-11-17 | 2022-05-05 |
| Study to Evaluate the Influence of Tegoprazan on the Pharmacokinetics of Proguanil in Healthy Volunteers Atovaquone / Proguanil 250/100 mg, Tegoprazan 50 mg, Esomeprazole 40 mg - Gastroesophageal Reflux Disease | Phase 1 | Completed | Seoul National University Hospital | 19 | 2020-11-25 | 2021-09-27 |
| Malarone Pharmacokinetics Under Simulated Physiologic Stressors of Deployment Malarone - Exercise, Pharmacokinetics | Phase 4 | Withdrawn | Walter Reed Army Institute of Research (WRAIR) | 2019-05-24 | 2021-04-30 | |
| Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2 Piperaquine (low dose), Piperaquine (high dose), Sulfadoxine pyrimethamine - Malaria,Falciparum, Gametocytes | Not applicable | Completed | Radboud University Medical Center | 24 | 2018-05-07 | 2020-07-07 |
| Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis atovaquone/proguanil 250mg/100mg (A/P), PfSPZ Challenge (NF54), NaCl 0,9% - Malaria | Phase 1 | Completed | University Hospital Tuebingen | 30 | 2016-11-28 | 2019-07-15 |
| Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis. Chloroquine, Atovaquone and Proguanil, Doxycycline - Rabies | Phase 4 | Completed | State University of New York - Upstate Medical University | 103 | 2016-11-11 | 2021-05-13 |
| Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1 Sulfadoxine-pyrimethamine (low dose), Piperaquine (low dose), Sulfadoxine-pyrimethamine (high dose) - Malaria | Phase 1 / Phase 2 | Completed | Radboud University Medical Center | 29 | 2016-06-01 | 2018-03-23 |
| DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria DSM265 400mg, Placebo to DSM265 400 mg, Plasmodium falciparum sporozoite challenge - Plasmodium Falciparum, Malaria | Phase 1 | Completed | Medicines for Malaria Venture | 22 | 2015-10-01 | 2021-01-13 |
| Chemoprophylaxis and Plasmodium Falciparum NF54 Sporozoite Immunization Challenged by Heterologous Infection CPS-immunization, malaria challenge infection, P. falciparum NF135.C10, malaria challenge infection, P. falciparum NF166.C8 - Malaria | Not applicable | Completed | Radboud University Medical Center | 40 | 2014-10-01 | 2016-02-23 |
| Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis CPS-immunization, Controlled Human Malaria Infection, chloroquine - Malaria | Not applicable | Completed | Radboud University Medical Center | 15 | 2014-06-01 | 2015-08-10 |
| Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis Chloroquine prophylaxis, Mefloquine prophylaxis, Immunization - Malaria, Plasmodium Falciparum | Not applicable | Completed | Radboud University Medical Center | 20 | 2012-01-01 | 2013-04-29 |
| Weekly Dosing of Malarone ® for Prevention of Malaria Atovaquone Proguanil, Procedure - malaria challenge - Malaria | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 35 | 2009-09-01 | 2013-11-25 |
| Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function Artesunate-mefloquine, Atovaquone-proguanil, Artemether-lumefantrine - Malaria, Falciparum | Phase 4 | Completed | Novartis | 265 | 2007-05-01 | 2011-04-05 |
| Safety and Efficacy Study of IV Artesunate to Treat Malaria Artesunate, Malarone - Malaria | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 30 | 2006-03-01 | 2019-10-01 |
Malaria (10) · Malaria, Falciparum (6) · Gastroesophageal Reflux (1) · Motor Activity (1) · Rabies (1)
Radboud University Medical Center (5) · Medicines for Malaria Venture (2) · U.S. Army Medical Research and Development Command (2) · Novartis (1) · Seoul National University Hospital (1) · State University of New York - Upstate Medical University (1) · University Hospital Tuebingen (1) · Walter Reed Army Institute of Research (WRAIR) (1)
Netherlands (5) · United States (3) · Colombia (1) · Germany (1) · Kenya (1) · South Korea (1) · United Kingdom (1)
Gregory Deye, MD (1) · Leo G Visser, MD, PhD (1) · Peter G Kremsner, Prof (1) · Robert W Sauerwein, Prof (1) · Robert W Sauerwein, Prof. (1) · SeungHwan Lee, MD, PhD (1) · Shon A Remich, MD (1) · Timothy Endy, MD (1) · Ulrike Lorch, MD FRCA FFPM (1)
PMID 22052893, PMID 25396417, PMID 28363637, PMID 28903777, PMID 29482720, PMID 31146732, PMID 31743394, PMID 32239171, PMID 36897544, PMID 38918235