4 completed, 3 recruiting. 7 Phase 1.
By phase and status
Follow KarXT: new trials by email Literature Review of KarXT trials Research Report on KarXT
Trials (filtered) newest first · largest first
All 7 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|
A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants
Xanomeline/ Trospium Chloride - Healthy Volunteers | Phase 1 | Recruiting | 56 | 2025-10-13 | 2026-10-13 |
A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin
KarXT, Midazolam, Fexofenadine - Healthy Volunteers | Phase 1 | Completed | 62 | 2025-09-29 | 2026-07-22 |
A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT
KarXT - Schizophrenia | Phase 1 | Recruiting | 131 | 2025-09-03 | 2026-09-02 |
A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, Explore the Effect of Food After Multiple Doses of Selected Prototypes, and Evaluate Alternative Formulations of KarX and KarXT Following Single and Multiple Ascending Doses
Xanomeline/Trospium Chloride Capsule, Xanomeline Enteric Capsule, Trospium Chloride - Healthy Volunteers | Phase 1 | Recruiting | 236 | 2025-06-27 | 2026-08-17 |
Safety, Tolerability, and Pharmacokinetics of KarXT and Dual-burst Release of Xanomeline With Immediate-release Trospium Chloride in Adolescents With Psychiatric Disorders
KarXT, KarX-EC - Psychiatric Disorders | Phase 1 | Completed | 24 | 2025-04-29 | 2025-08-06 |
A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants
Xanomeline/Trospium Chloride, Lithium, Valproic Acid - Healthy Volunteers | Phase 1 | Completed | 133 | 2024-12-26 | 2026-02-24 |
A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Versus KarXT in Healthy Adult and Elderly Participants of Japanese Ethnicity and to Assess the Effect of Omeprazole on the PK of Xanomeline With Trospium Chloride in Healthy Adult Participants
KarXT, KarX-EC, Placebo - Healthy Volunteers | Phase 1 | Completed | 78 | 2024-10-01 | 2025-07-04 |
Conditions studied
Mental Disorders (1) · Schizophrenia (1)
Sponsors
Karuna Therapeutics, Inc., a Bristol Myers Squibb company (4) · Bristol-Myers Squibb (3)
Countries
United States (6) · United Kingdom (1)