11 completed, 5 unknown, 1 not yet recruiting, 1 terminated. 9 Phase 4, 6 Not applicable, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 9 | Completed 5, Unknown 3, Terminated 1 |
| Not applicable | 6 | Completed 4, Unknown 2 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 1 | Not yet recruiting 1 |
Follow Intravenous Tranexamic Acid: new trials by email Literature Review of Intravenous Tranexamic Acid trials Research Report on Intravenous Tranexamic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nebulized Versus Intravenous Tranexamic Acid for Hemoptysis nebulized tranexamic acid, Intravenous Tranexamic Acid - Hemoptysis, Pulmonary Hemorrhage | Phase 3 | Not yet recruiting | Assiut University | 170 | 2026-07-01 | 2026-07-14 |
| Tranexamic Acid Versus Misoprostol to Reduce Blood Loss During and After Cesarean Section Intravenous Tranexamic Acid, rectal misoprostol - Blood Loss, Surgical, Blood Loss, Postoperative | Phase 4 | Completed | Medicare Hospital (Pvt) Limited | 214 | 2025-03-01 | 2026-07-17 |
| Nebulized Versus Intravenous Tranexamic Acid on Surgical Field Quality in Patients Undergoing Endoscopic Sinus Surgeries nebulized tranexamic acid, intravenous tranexamic acid - Nebulization, Intravenous | Phase 4 | Completed | Cairo University | 60 | 2025-01-24 | 2026-09-22 |
| Efficacy of Topical Tranexamic Acid in Reducing Blood Loss During CS in Patients With Placenta Previa Topical tranexamic acid, Intravenous tranexamic acid - Placenta Previa | Not applicable | Unknown | Cairo University | 56 | 2024-07-24 | 2024-07-23 |
| Combined Tranexamic Acid Use in Total Hip Replacement Surgery Intravenous Tranexamic Acid, Combined Intravenous and Intraarticular Tranexamic Acid - Total Hip Arthroplasty, Tranexamic Acid Administration | Not applicable | Completed | St. Anne's University Hospital Brno, Czech Republic | 58 | 2024-06-01 | 2026-05-28 |
| Phenylephrine Versus Tranexamic Acid to Control Bleeding in Patients Undergoing Inferior Turbinoplasty by Coblation Topical Phenylephrine Solution, intravenous tranexamic acid - Intraoperative Bleeding, Coblation Turbinoplasty | Not applicable | Unknown | Assiut University | 80 | 2023-05-01 | 2023-05-03 |
| Tranexamic Acid in Functional Endoscopic Sinus Surgery Oral tranexamic acid, Intravenous tranexamic acid - Anesthesia | Phase 4 | Completed | Ain Shams University | 159 | 2022-12-03 | 2023-05-03 |
| Tranexamic Acid Versus Vaginal Misoprostol in Abdominal Myomectomy intravenous tranexamic acid, vaginal misoprostol, placebo - Myomectomy | Phase 4 | Unknown | Cairo University | 162 | 2020-05-10 | 2020-04-24 |
| Intravenous Tranexamic Acid Versus IV Carbetocin in Abdominal Myomectomy intravenous tranexamic acid, intravenous carbetocin, placebo - Myomectomy | Phase 4 | Unknown | Cairo University | 153 | 2020-05-01 | 2020-04-22 |
| Intravenous Tranexamic Acid Versus Vaginal Dinoprostone in Abdominal Myomectomy intravenous tranexamic acid, vaginal dinoprostone, vaginal placebo - Myomectomy | Phase 4 | Unknown | Cairo University | 180 | 2020-04-30 | 2020-04-22 |
| Reducing Blood Loss During Cesarean Section by Topical Versus IV Tranexamic Acid normal saline arm group, intravenous tranexamic acid, Topical tranexamic acid - Cesarean Section Complications | Not applicable | Completed | Aswan University Hospital | 450 | 2018-11-01 | 2020-08-05 |
| Reducing Blood Loss During Cesarean Hysterectomy for Placenta Accreta Spectrum intravenous tranexamic acid, Topical tranexamic acid, Normal saline - Cesarean Section Complications | Not applicable | Completed | Aswan University Hospital | 80 | 2018-01-01 | 2021-08-09 |
| Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement Intravenous tranexamic acid, Topical tranexamic acid, Intravenous saline - Osteoarthritis, Knee | Phase 4 | Completed | Hospital for Special Surgery, New York | 76 | 2015-11-19 | 2020-03-25 |
| Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty Intravenous Placebo, Intravenous Tranexamic Acid - Blood Loss | Phase 4 | Terminated | NYU Langone Health | 52 | 2015-04-21 | 2021-09-28 |
| Oral vs. Intravenous TXA Study Proposal: TJA Oral Tranexamic Acid, Intravenous Tranexamic Acid - Blood Loss After Primary Total Joint Arthroplasty, Need for Blood Transfusion After Total Joint Arthroplasty | Not applicable | Completed | Rush University Medical Center | 167 | 2014-06-01 | 2017-11-28 |
| Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical Topical Tranexamic Acid, Intravenous Tranexamic Acid - Osteoarthritis | Phase 4 | Completed | Hospital for Special Surgery, New York | 640 | 2013-05-01 | 2019-11-27 |
| Peri-articular Tranexamic Acid Injection in Total Knee Arthroplasty Peri-articular tranexamic acid, Intravenous tranexamic acid - Osteoarthritis, Knee | Phase 2 | Completed | Thammasat University | 60 | 2012-10-01 | 2016-07-12 |
| Tranexamic Acid in Cyanotic Heart Defects Normal saline at induction, Normal saline infusion, Intravenous tranexamic acid - Postoperative Hemorrhage | Phase 2 | Completed | Assiut University | 120 | 2009-01-01 | 2018-01-31 |
Blood Loss, Surgical (2) · Hemorrhage (2) · Osteoarthritis, Knee (2) · Postoperative Hemorrhage (2) · Hemoptysis (1) · Joint Diseases (1) · Osteoarthritis (1) · Placenta Accreta (1) · Placenta Previa (1) · Postpartum Hemorrhage (1)
Cairo University (5) · Assiut University (3) · Aswan University Hospital (2) · Hospital for Special Surgery, New York (2) · Ain Shams University (1) · Medicare Hospital (Pvt) Limited (1) · NYU Langone Health (1) · Rush University Medical Center (1) · St. Anne's University Hospital Brno, Czech Republic (1) · Thammasat University (1)
Egypt (5) · United States (4) · Czechia (1) · Pakistan (1) · Thailand (1)
Craig J Della Valle, MD (1) · David Mayman, MD (1) · Jan A Koenig, M.D. (1) · Kareem MA Nawwar, M.D. (1) · Kethy Jules-Elysee, MD (1) · Nadia E M Gaballah, M.Sc. (1) · Nevan M Abbas Elmekawy, M.D. (1) · Piya Pinsornsak, MD (1) · Shahid I Rao, FCPS (1) · Tamer M Khair, M.D. (1)