5 active not recruiting, 5 completed, 1 recruiting. 10 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Active not recruiting 5, Completed 5 |
| Phase 2 | 7 | Completed 4, Active not recruiting 2, Recruiting 1 |
Follow INO-9012: new trials by email Literature Review of INO-9012 trials Research Report on INO-9012
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Neoantigen Vaccine Plus IL-12 (INO-9012) Versus Active Surveillance in Subjects With High-Risk HCC GNOS-PV02 + INO-9012 delivered by intradermal injection, followed by electroporation, Electroporation Device, INO-9012 - HCC | Phase 2 | Recruiting | Geneos Therapeutics | 90 | 2026-09-01 | 2026-09-23 |
| INO 5401 Vaccination in BRCA1/2 Mutation Carriers INO-5401, INO-9012, Cellectra 2000 - BRCA1/2 Mutation | Phase 1 | Active not recruiting | University of Pennsylvania | 44 | 2021-04-20 | 2026-10-21 |
| Neoantigen-based Personalized DNA Vaccine in Patients With Newly Diagnosed, Unmethylated Glioblastoma Personalized neoantigen DNA vaccine supplied by Geneos Therapeutics, CELLECTRA®2000 EP Device supplied by Geneos Therapeutics, Plasmid encoded IL-12 - Glioblastoma | Phase 1 | Active not recruiting | Washington University School of Medicine | 9 | 2020-07-14 | 2026-10-23 |
| GNOS-PV02 Personalized Neoantigen Vaccine, INO-9012 and Pembrolizumab in Subjects With Advanced HCC GNOS-PV02, INO-9012, Pembrolizumab - HCC | Phase 1 / Phase 2 | Active not recruiting | Geneos Therapeutics | 36 | 2020-03-01 | 2026-09-24 |
| Therapeutic Vaccination in Treated HIV Disease PENNVAX-GP, INO-6145, INO-9012 - HIV-1-infection | Phase 1 / Phase 2 | Completed | Steven Deeks | 56 | 2018-08-01 | 2023-05-31 |
| INO-5401 + INO-9012 in Combination With Atezolizumab in Locally Advanced Unresectable or Metastatic/Recurrent Urothelial Carcinoma INO-5401, INO-9012, Atezolizumab - Urothelial Carcinoma | Phase 1 / Phase 2 | Completed | Inovio Pharmaceuticals | 35 | 2018-07-24 | 2026-09-02 |
| INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM) INO-5401, INO-9012, Cemiplimab - Glioblastoma | Phase 1 / Phase 2 | Active not recruiting | Inovio Pharmaceuticals | 52 | 2018-05-31 | 2026-10-22 |
| DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection Electroporation-Mediated Plasmid DNA Vaccine Therapy, HCV DNA Vaccine INO-8000, Laboratory Biomarker Analysis - Chronic Hepatitis, Hepatitis C Infection | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 33 | 2016-06-06 | 2026-09-11 |
| hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse INO-1400, INO-9012, INO-1401 - Breast Cancer, Lung Cancer | Phase 1 | Completed | Inovio Pharmaceuticals | 93 | 2014-12-01 | 2018-11-19 |
| Study of HPV Specific Immunotherapy in Participants With HPV Associated Head and Neck Squamous Cell Carcinoma INO-3112, CELLECTRA™-5P - Head and Neck Squamous Cell Cancer | Phase 1 / Phase 2 | Completed | Inovio Pharmaceuticals | 22 | 2014-08-13 | 2021-01-22 |
| A Study of INO-3112 DNA Vaccine With Electroporation in Participants With Cervical Cancer INO-3112, CELLECTRA™-5P - Cervical Cancer | Phase 1 / Phase 2 | Completed | Inovio Pharmaceuticals | 10 | 2014-06-06 | 2021-02-21 |
Carcinoma, Hepatocellular (2) · Glioblastoma (2) · Breast Neoplasms (1) · Carcinoma, Transitional Cell (1) · Colorectal Neoplasms (1) · Esophageal Neoplasms (1) · Head and Neck Neoplasms (1) · Hepatitis C (1) · Hepatitis, Chronic (1) · Lung Neoplasms (1) · Ovarian Neoplasms (1) · Pancreatic Neoplasms (1) · Stomach Neoplasms (1) · Uterine Cervical Neoplasms (1)
Inovio Pharmaceuticals (5) · Geneos Therapeutics (2) · National Cancer Institute (NCI) (1) · Steven Deeks (1) · University of Pennsylvania (1) · Washington University School of Medicine (1)
United States (11) · New Zealand (2) · Puerto Rico (1)
Jeffrey Skolnik, MD (4) · Anthony Shields, MD (1) · Ashish Chintakuntlawar, MBBS, PhD (1) · Autumn McRee, MD (1) · Jeffrey M Jacobson (1) · Jennifer Johnson, MD (1) · Nathan Bahary, MD (1) · Robert Vonderheide, MD, PhD (1) · Steven Deeks, MD (1) · Susan Domchek, MD (1) · Tanner M Johanns, M.D., Ph.D. (1)
PMID 38584166, PMID 38991631, PMID 42120910
N01CN00042 (1), P30CA015083 (1), R01NS112712 (1), U01AI131296 (1)