11 completed. 11 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 11 |
| Phase 2 | 2 | Completed 2 |
Follow IFL protocol: new trials by email Literature Review of IFL protocol trials Research Report on IFL protocol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ramucirumab Plus FOLFIRI Versus Ramucirumab Plus Paclitaxel in Patients With Advanced or Metastatic Gastric Cancer, Who Failed One Prior Line of Palliative Chemotherapy FOLFIRI, Ramucirumab, Paclitaxel - Advanced Gastric or EGJ Cancer | Phase 2 / Phase 3 | Completed | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | 429 | 2017-05-10 | 2026-07-02 |
| Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177) mFOLFOX6, FOLFIRI, Pembrolizumab - Colorectal Carcinoma | Phase 3 | Completed | Merck Sharp & Dohme LLC | 307 | 2015-11-30 | 2024-10-03 |
| Erbitux MEtastatic Colorectal Cancer Strategy Study Cetuximab, FOLFIRI - Antineoplastic Agents | Phase 3 | Completed | Armando Orlandi | 607 | 2015-02-01 | 2020-03-31 |
| Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen AFLIBERCEPT AVE0005, FOLFIRI - Colorectal Cancer Metastatic | Phase 3 | Completed | Sanofi | 781 | 2012-05-30 | 2018-04-17 |
| Comparison of Treatment Effect of Chemotherapy With Panitumumab to Chemotherapy Alone Panitumumab, FOLFIRI - Metastatic Colorectal Cancer | Phase 3 | Completed | Amgen | 1186 | 2006-06-30 | 2022-09-23 |
| Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer bevacizumab, cetuximab, FOLFOX or - Colorectal Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 2334 | 2005-11-01 | 2026-08-07 |
| Metastatic Gastric Cancer FFCD 03-07 ECC, FOLFIRI - Stomach Cancer, Neoplasm Metastasis | Phase 3 | Completed | University Hospital, Toulouse | 416 | 2005-06-01 | 2011-10-12 |
| PACCE: Panitumumab Advanced Colorectal Cancer Evaluation Study Oxaliplatin Based Chemotherapy, Panitumumab, Irinotecan Based Chemotherapy - Colorectal Cancer | Phase 3 | Completed | Amgen | 1053 | 2005-06-01 | 2018-10-17 |
| Intensified Chemotherapy in CRC After Resection of Liver Metastases FOLFIRI, FOLFOX-4, FOLFIRI-HD - Colorectal Cancer, Liver Metastases | Phase 2 / Phase 3 | Completed | Institut du Cancer de Montpellier - Val d'Aurelle | 124 | 2004-04-01 | 2026-02-05 |
| Phase III Trial of DP Followed by FOLFIRI or the Reverse Sequence in Unresectable Gastric Cancer DP, FOLFIRI - Gastric Cancer, Metastases | Phase 3 | Completed | Samsung Medical Center | 200 | 2003-05-01 | 2012-01-12 |
| FOLFOXIRI Compared With FOLFIRI for Metastatic Colorectal Cancer FOLFIRI, FOLFOXIRI - Metastatic Colorectal Cancer | Phase 3 | Completed | Gruppo Oncologico del Nord-Ovest | 244 | 2001-11-01 | 2015-03-11 |
Colorectal Neoplasms (7) · Neoplasm Metastasis (2) · Neoplasms (2) · Rectal Neoplasms (2) · Stomach Neoplasms (2) · Colonic Neoplasms (1) · Parkinson Disease 4, Autosomal Dominant Lewy Body (1)
Amgen (2) · Alliance for Clinical Trials in Oncology (1) · Armando Orlandi (1) · Gruppo Oncologico del Nord-Ovest (1) · Institut du Cancer de Montpellier - Val d'Aurelle (1) · Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest (1) · Merck Sharp & Dohme LLC (1) · Samsung Medical Center (1) · Sanofi (1) · University Hospital, Toulouse (1)
Italy (4) · Canada (2) · France (2) · Germany (2) · United States (2) · Austria (1) · Belgium (1) · Brazil (1) · Chile (1) · Czechia (1) · Denmark (1) · Finland (1) · Ireland (1) · Israel (1) · Lebanon (1)
Alan Venook, MD (1) · Alfredo Falcone, MD (1) · Salah-Eddin Al-Batran, Prof (1) · Won Ki Kang, MD (1)
PMID 16356309, PMID 17553204, PMID 22070868, PMID 23955585, PMID 25287828, PMID 26049686, PMID 26341920, PMID 26861604, PMID 28632865, PMID 29627309, PMID 30679026, PMID 31042420, PMID 31221542, PMID 31378656, PMID 31408415, PMID 31548349, PMID 31902066, PMID 33264544, PMID 33812497, PMID 35202974, PMID 35427471, PMID 36067452, PMID 36369901, PMID 37337155, PMID 38181312, PMID 38457761
2014 (1), 2015 (1), U10CA037447 (1)