7 completed, 2 active not recruiting, 2 unknown, 1 recruiting. 8 Not applicable, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 4, Active not recruiting 2, Unknown 2 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Hyperinsulinemic euglycemic clamp: new trials by email Literature Review of Hyperinsulinemic euglycemic clamp trials Research Report on Hyperinsulinemic euglycemic clamp
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Total-body Glucose Utilization in Obesity Movies, Cold, Hyperinsulinemic euglycemic clamp - Obesity and Overweight | Phase 4 | Recruiting | Turku University Hospital | 60 | 2023-01-25 | 2024-12-18 |
| Insulin Sensitivity After Breast Cancer Insulin - Insulin Sensitivity/Resistance, Breast Cancer | Not applicable | Unknown | University of Copenhagen | 24 | 2021-08-01 | 2021-08-18 |
| Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes Maximal ATP Production (ATPmax), Exercise Testing (VO2max), Muscle Biopsy - Type 2 Diabetes | Not applicable | Active not recruiting | AdventHealth Translational Research Institute | 39 | 2021-03-30 | 2026-03-30 |
| Type 2 Diabetes and the Brain in Adolescents Hyperglycemic clamp, Hyperinsulinemic Euglycemic clamp - Type 2 Diabetes Mellitus, Obesity | Not applicable | Completed | Nemours Children's Clinic | 18 | 2017-12-05 | 2019-09-09 |
| Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects Continous IV infusion of Nesiritide, Hyperinsulinemic euglycemic clamp, Placebo - Diabetes | Phase 1 | Completed | AdventHealth Translational Research Institute | 6 | 2017-07-13 | 2020-03-10 |
| Neuromolecular Risk Factors for Obesity (PROSPECT) fMRI imaging, [11C]carfentanil PET scan, [18F]FMPEP-d2 PET scan - Obesity | Not applicable | Unknown | Turku University Hospital | 60 | 2017-04-04 | 2021-12-17 |
| Reprometabolic Syndrome Mediates Subfertility in Obesity Insulin, Intralipid, Dextrose - Obesity, Infertility | Not applicable | Active not recruiting | University of Colorado, Denver | 84 | 2016-06-01 | 2026-03-02 |
| Effects of Intranasal Insulin Administration on Tissue Specific Insulin Sensitivity Actrapid, Placebo, [18F]-FDG PET-CT - Insulin Resistance | Not applicable | Completed | Turku University Hospital | 10 | 2016-04-01 | 2018-01-26 |
| Fatty Acid Oxidation Defects and Insulin Sensitivity Intralipid/Heparin, Glycerol/Saline, Hyperinsulinemic euglycemic clamp - Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency | Not applicable | Completed | Oregon Health and Science University | 41 | 2016-02-01 | 2024-01-30 |
| Insulin Sensitivity in Patients With Atopic Dermatitis Hyperinsulinemic euglycemic clamp - Atopic Dermatitis/Eczema, Type 2 Diabetes | Completed | University Hospital, Gentofte, Copenhagen | 32 | 2015-11-01 | 2019-10-18 | |
| Assessment of Liver Glucose Metabolism in Diabetic Subjects intravenous glucose tolerance test, hyperinsulinemic euglycemic clamp - Newly Diagnosed Type 2 Diabetes (During the Last 12 Months) | Not applicable | Completed | German Diabetes Center | 22 | 2011-07-01 | 2023-06-05 |
| Regulation of Tissue Lipolysis by Insulin in Type 2 Diabetes Hyperinsulinemic euglycemic clamp - Type 2 Diabetes | Completed | Maastricht University Medical Center | 20 | 2007-06-01 | 2012-10-12 |
Diabetes Mellitus, Type 2 (5) · Insulin Resistance (4) · Obesity (4) · Behavior, Addictive (1) · Breast Neoplasms (1) · Carnitine Palmitoyltransferase II Deficiency, Late-Onset (1) · Dermatitis, Atopic (1) · Diabetes Mellitus (1) · Eczema (1) · Hyperglycemia (1) · Hyperinsulinism (1) · Infertility (1) · Medium chain acyl CoA dehydrogenase deficiency (1) · Overweight (1) · Pediatric Obesity (1)
Turku University Hospital (3) · AdventHealth Translational Research Institute (2) · German Diabetes Center (1) · Maastricht University Medical Center (1) · Nemours Children's Clinic (1) · Oregon Health and Science University (1) · University Hospital, Gentofte, Copenhagen (1) · University of Colorado, Denver (1) · University of Copenhagen (1)
United States (5) · Finland (3) · Denmark (2) · Germany (1) · Netherlands (1)
Bret Goodpaster, PhD (1) · Ellen Blaak, PhD (1) · Filip K Knop, MD, PhD (1) · Jacob P Thyssen, MD,PhD,DMSc (1) · Lauri Nummenmaa, Professor (1) · Lydia Snyder, MD (1) · Lykke Sylow, PhD (1) · Michael Roden, Prof., MD (1) · Nanette Santoro, MD (1) · Pirjo Nuutila, M.D., Ph.D. (1) · Pirjo Nuutila, MD,PhD (1) · Pirjo Nuutila, professor (1) · Richard Pratley, MD (1)
PMID 23907381, PMID 25047649, PMID 33838870, PMID 38710978
2015 (1), UL1TR001082 (1)