16 completed, 3 unknown, 2 terminated, 1 withdrawn. 9 Phase 4, 3 Not applicable, 3 Phase 2, 2 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 9 | Completed 6, Terminated 2, Unknown 1 |
| Not applicable | 3 | Completed 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
| Early Phase 1 | 1 | Unknown 1 |
Follow hylan: new trials by email Literature Review of hylan trials Research Report on hylan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial Comparing Three Single Dose Injections for Knee Osteoarthritis Zilretta, Synvisc-One 48 MG in 6 ML Prefilled Syringe, Monovisc 88 MG Per 4 ML Prefilled Syringe - Osteoarthritis, Knee | Phase 4 | Terminated | Ohio State University | 6 | 2022-08-02 | 2026-09-17 |
| Efficacy of "Aquoral Lipo" Artificial Tears in Contact Lens Wearers With Discomfort Aquoral Lipo (Esteve), Hyabak (Thea) - Contact Lens Complication | Not applicable | Completed | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | 41 | 2022-03-01 | 2024-10-08 |
| Project Arthritis Recovering Quality of Life Through Education - Hip Patients will be submitted to needle lavage, followed by the injection of 3mL of hylan and 1 mL of ropivacaine, Patients will be submitted to needle lavage, followed by the injection of 0,5mL triamcinolone (10mg) and 1 mL of ropivacaine, - Hip Osteoarthritis | Not applicable | Unknown | University of Sao Paulo General Hospital | 48 | 2019-09-01 | 2019-07-29 |
| Knee Injection RCT Ketorolac Tromethamine Injection, Methylprednisolone Acetate Injection, Hylan G-F 20 - Osteoarthritis | Phase 4 | Terminated | UConn Health | 18 | 2018-07-05 | 2020-02-18 |
| Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis Hyruan-One, Hylan G-F 20, Normal saline - Knee Osteoarthritis | Phase 4 | Completed | Thammasat University | 276 | 2018-04-01 | 2025-09-22 |
| Clinical Trial to Evaluate the Use of Platelet Rich Plasma in Front Hyaluronic Acid in Coxarthrosis Platelet rich plasma, Hylan G-F 20 - Coxarthrosis | Phase 3 | Completed | Fundación Pública Andaluza Progreso y Salud | 74 | 2016-03-01 | 2019-02-22 |
| A Phase 2 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis JointStem, Synvisc-One - Osteoarthritis, Knee | Phase 2 | Completed | Nature Cell Co. Ltd. | 28 | 2016-02-16 | 2021-08-10 |
| Comparative Effectiveness of Hyaluronic Acid Injections for Management of Knee Osteoarthritis Hyaluronic Acid injections - Knee Osteoarthritis | Completed | University of Arkansas | 13849 | 2016-02-01 | 2021-08-05 | |
| Outcomes of Injections in Patients Waiting for Total Knee Replacement Hylan G-F 20, Triamcinolone - Osteoarthritis of the Knee | Phase 4 | Unknown | Universidade Federal Fluminense | 120 | 2015-09-01 | 2017-03-27 |
| Treatment of Insertional Achilles Tendinopathy by Hyaluronic Acid Injection Injection of Hyaluronic Acid -" SYNVISC" (hylan G-F 20) - Insertional Achilles Tendinitis | Early Phase 1 | Unknown | Meir Medical Center | 20 | 2015-03-01 | 2015-02-23 |
| To Evaluate the Optimum Dose of Platelet Rich Plasma in Knee Osteoarthritis and Compare Efficacy With Hyaluronic Acid Platelet rich plasma, Hyaluronic Acid - Knee Osteoarthritis | Phase 2 | Completed | Dr. Himanshu Bansal Foundation | 100 | 2014-10-21 | 2019-12-13 |
| A Study of the Efficacy and Safety of Synvisc® in Chinese Subjects With Symptomatic Osteoarthritis of the Knee(s) Hylan G-F 20 - Osteoarthritis | Phase 4 | Completed | Sanofi | 237 | 2012-03-01 | 2016-02-24 |
| Evaluation of the Effect of Adding Corticosteroid to Viscosupplementation Hylan GF-20 alone, Triamcinolone - Osteoarthritis | Phase 4 | Completed | University of Sao Paulo General Hospital | 108 | 2011-03-01 | 2014-12-23 |
| Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee Hylan G-F 20, Corticosteroid - Knee Osteoarthritis | Phase 4 | Completed | Thammasat University | 100 | 2011-01-01 | 2014-04-22 |
| Study of Safety and Efficacy of 6 mL Synvisc-One (Hylan G-F 20) in Indian Patients With Symptomatic Osteoarthritis of Knee(s) After Initial and Repeat Treatment Synvisc-One - Osteoarthritis | Phase 4 | Completed | Genzyme, a Sanofi Company | 394 | 2010-02-01 | 2017-08-07 |
| Study of Viscosupplementation for the Treatment of Knee Pain After Menisectomy Hylan G-F 20, Sham Injection - Arthralgia | Not applicable | Withdrawn | Grant Jones | 2009-12-01 | 2021-02-25 | |
| A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb Synvisc (Hylan G-F20; hyaluronan injection), Bupivicaine (local anesthesia injection), Kenalog (triamcinolone; corticosteroid injection) - Osteoarthritis | Phase 3 | Completed | Hospital for Special Surgery, New York | 200 | 2006-08-01 | 2017-07-07 |
| Synvisc to Treat Osteoarthritis of the Temporomandibular Joint High molecular weight hylan (Synvisc) injection - Osteoarthritis | Phase 2 | Completed | National Institute of Dental and Craniofacial Research (NIDCR) | 60 | 2004-02-01 | 2008-03-04 |
| Retrospective Follow-up Study of Synvisc® in Patients With Knee Osteoarthritis Synvisc® - Osteoarthritis | Completed | Boehringer Ingelheim | 16 | 2002-04-01 | 2014-07-22 | |
| Retrospective Follow-up of Synvisc® in Active Patients With Knee Osteoarthritis Synvisc® - Osteoarthritis | Completed | Boehringer Ingelheim | 41 | 2002-04-01 | 2014-07-21 |
Showing 20 of 22. Sign in to see all of them.
Osteoarthritis (11) · Osteoarthritis, Knee (7) · Osteoarthritis, Hip (2) · Arthralgia (1) · Chronic Pain (1) · Temporomandibular Joint Disorders (1)
Boehringer Ingelheim (4) · Thammasat University (2) · University of Sao Paulo General Hospital (2) · Dr. Himanshu Bansal Foundation (1) · Fundación Pública Andaluza Progreso y Salud (1) · Genzyme, a Sanofi Company (1) · Grant Jones (1) · Hospital for Special Surgery, New York (1) · Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA (1) · Meir Medical Center (1) · National Institute of Dental and Craniofacial Research (NIDCR) (1) · Nature Cell Co. Ltd. (1) · Ohio State University (1) · Sanofi (1) · UConn Health (1)
United States (6) · Brazil (3) · Spain (2) · Thailand (2) · China (1)
Andre Campos (1) · Bradley Martin, PharmD, PhD (1) · Grant Jones, MD (1) · Guilherme Ocampos, MD (1) · Lisa A. Mandl, MD, MPH (1) · Luis Javier Roca Ruiz, Graduate (1) · Meir Nyska, Prop (1) · Michael Baria (1) · Mohamad J. Halawi, MD (1) · Nattapol Tammachote, MD (1) · Nattapol Tammachote, MD, MSc (1) · Olavo Pires de Camargo, Prof. Dr. (1)
PMID 25925602, PMID 26861957, PMID 28146403
2014 (1), K23AR050607 (1)